归经学说与辨证理论的关系探讨

归经学说萌芽于《黄帝内经》,至寇宗爽《本草衍义》首提“归经”的概念,张元素在实践经验的基础上,提出归经学说,归经学说至此完善成熟。归经学说的形成与脏腑辨证密不可分,脏腑辨证的思想也是源于《内经》,经张仲景《伤寒杂病论》、华佗《中藏经》、孙思邈《备急千金要方》、钱乙〈〈sDJL药证直诀》的发展,张元素将脏腑辨证归纳整理,形成体系。脏腑辨证理论的完善促进归经学说形成,归经学说是脏腑辨证理论在中药临床中的体现。     

丹参接骨胶囊对骨折SD大鼠TGFβ1 mRNA及蛋白表达的影响

目的:建立左股骨中段闭合折骨经皮髓内克氏针固定的标准骨折模型,观察丹参接骨胶囊对SD大鼠骨折愈合过程中局部转化生长因子β1(transforming growth factor beta 1,TGF-β1)mRNA、蛋白表达,通过RT-PCR,ELISA法进行分析转化生长因子β1的表达,探讨丹参接骨胶囊对大鼠骨折愈合的机制。方法:建立闭合性的股骨干骨折髓内固定模型,分别给与相应药物灌胃治疗,在不同时相通过RT-PCR,ELISA法进行分析TGF-β1 mRNA及蛋白表达。结果:丹参接骨胶囊能促进骨折SD大鼠TGF-β1 mRNA及蛋白的表达。结论:大鼠股骨中段闭合折骨髓内克氏针固定骨折模型稳定,可操作性强,重复性好。丹参接骨胶囊能促进骨折SD大鼠TGF-β1 mRNA及蛋白的表达。     

中西医结合治疗扩张型心肌病8例的临床观察

<正>扩张型心肌病(dilated cardio-myopathy,DCM)是临床上常见的特发性心肌病,以心脏扩大、心力衰竭为主要临床表现,预后不良。笔者从本院门诊或病房收治过8例DCM病人,采取     

汗为心之液临床意义之浅析

<正>"汗出与否"在中医临床中极受重视,清代医家陈修园《医学实在易》十问歌写道:"一问寒热二问汗",其将"问汗"排在第二位,可见前人早已认识到了汗的重要性。通过询问汗之有无,可了解津液之盈亏与存亡,病性之寒热虚实和机体的阴阳盛衰,并直接指导临床治     

风湿定痛汤治疗膝骨性关节炎296例

目的:研究膝骨性关节炎的有效治疗方法及药物。方法:治疗组296例采用内服风湿定痛汤治疗,并与对照组140例服用西药非甾体药物治疗进行比较,判断治疗结果。结果:治疗组总有效率为91.0%,对照组为75.0%,治疗组疗效优于对照组(P<0.05)。结论:风湿定痛汤治疗膝骨性关节炎疗效满意。     

冬凌草片辅助榄香烯膀胱灌注预防浅表性膀胱癌术后复发的前瞻性临床分析

目的：观察分析冬凌草片辅助榄香烯膀胱灌注预防浅表性膀胱癌术后复发的前瞻性临床疗效及安全性。方法：选取2008年6月至2010年6月我院收治的75例浅表性膀胱癌患者,均采用保留膀胱经尿道肿瘤切除术。行前瞻性、随机对照临床研究,术后将其随机分为对照组和治疗组。治疗组38例,术后口服冬凌草片,术后1周行榄香烯膀胱内灌注;对照组37例,术后1周行榄香烯膀胱内灌注。随访2年,观察患者肿瘤复发情况及不良反应。结果：对照组平均随访26.6个月,2年复发率16.22%。治疗组平均随访29.8月,2年复发率10.53%,两组患者2年复发率相比,差异有统计学意义（P〈0.05）。两组间的不良反应比较无统计学意义（P〉0.05）。结论：冬凌草片辅助榄香烯膀胱灌注预防浅表性膀胱癌术后复发有良好疗效,不良反应少,值得在临床广泛推广。     

丹参接骨胶囊对闭合性股骨骨折模型大鼠骨折愈合的影响

BACKGROUND: Salvia miltiorrhiza bone-setting capsule is a traditional Chinese medicine for the treatment of fractures due to activating blood circulation to dissipate blood stasis, reducing swelling and pain. OBJECTIVE: To observe the effects of Salvia miltiorrhiza bone-setting capsule on the fracture healing in a rat model of closed femoral fractures. METHODS: Rats were randomly divided into salvia miltiorrhiza bone-setting capsule group, physiological saline group and normal group. In the salvia miltiorrhiza bone-setting capsule group and physiological saline group, rat models of closed femoral fractures were prepared, and then given physiological saline and salvia miltiorrhiza bone-setting capsule 2 pills by intragastric administration. In the normal group, rats were housed normally. At 7, 14 and 28 days after fractures, hematoxylin-eosin staining conditions, serum osteocalcin, the expression of collagen type I, and the expression of protein and mRNA callus transforming growth factor-beta 1 were observed in the salvia miltiorrhiza bone-setting capsule group and physiological saline group. RESULTS AND CONCLUSION: (1) Hematoxylin-eosin staining demonstrated that at 7 days after fractures, no significant difference was found in pathological changes of femoral fracture in salvia miltiorrhiza bone-setting capsule group and physiological saline group. At 14 and 28 days after fractures, pathological repair was more obvious in the salvia miltiorrhiza bone-setting capsule group than in the physiological saline group. (2) At 3 and 7 days after fractures, serum osteocalcin and the expression of type I collagen were significantly increased in the salvia miltiorrhiza bone-setting capsule group and physiological saline group  (P < 0.05), and the expression trend was consistent in both groups. The expression was always higher in the salvia miltiorrhiza bone-setting capsule group than in the physiological saline group, and significant differences were found at 14 and 28 days after fractures (P < 0.01). (3) Transforming growth factor beta 1 expression reached a peak at 3 days after fractures, gradually reduced, increased at 14 days (the second peak), and diminished at 28 days in the salvia miltiorrhiza bone-setting capsule group and physiological saline group. The expression trend of transforming growth factor beta 1 was consistent in the salvia miltiorrhiza bone-setting capsule group and physiological saline group. At 7, 14 and 28 days, the transforming growth factor beta 1 expression was higher in the salvia miltiorrhiza bone-setting capsule group than in the physiological saline group. (4) Results showed that salvia miltiorrhiza bone-setting capsule could promote fracture healing, and its mechanism was probably associated with serum osteocalcin, the expression of collagen type I and transforming growth factor-β1.       

疏血通注射液治疗急性脑梗死40例疗效观察

目的：观察疏血通注射液治疗急性脑梗死的临床效果和不良反应。方法：将80例急性脑梗死患者随机分为治疗组40例和对照组40例，分别给予疏血通注射液和血塞通注射液治疗。结果：治疗组的总有效率为92．5％，显著优于对照组的70．0％（P〈0．05），且未见明显副作用。结论：疏血通注射液是治疗急性脑梗死安全、有效的药物。     

血塞通注射液联合黄芪注射液治疗高血压脑出血40例疗效观察

高血压急性脑出血是临床常见的脑血管病,发病急,致残率及致死率高.脑出血最重要的病理生理改变是血肿本身及其血肿周围继发性损害一脑缺血、脑水肿.为了提高高血压脑出血患者的生存质量,笔者自2004年6月以来运用血塞通注射液联合黄芪注射液配合西药治疗本病40例,取得较好疗效,现报道如下.     

活血化瘀临床应用研究

血瘀证与活血化瘀研究已成为中西医结合研究最活跃、最有成效的领域之一,并且广泛运用于内、外、妇、皮肤科等科,包括冠心病、高血压、糖尿病、肿瘤、硬皮病、肝硬化等多种疾病。就活血化瘀法在内科临床常见病中的应用做一概述。