全文获取类型
收费全文 | 20441篇 |
免费 | 1118篇 |
国内免费 | 92篇 |
专业分类
耳鼻咽喉 | 240篇 |
儿科学 | 470篇 |
妇产科学 | 389篇 |
基础医学 | 2605篇 |
口腔科学 | 1181篇 |
临床医学 | 1449篇 |
内科学 | 4976篇 |
皮肤病学 | 386篇 |
神经病学 | 1793篇 |
特种医学 | 385篇 |
外科学 | 3254篇 |
综合类 | 205篇 |
一般理论 | 7篇 |
预防医学 | 1572篇 |
眼科学 | 463篇 |
药学 | 1186篇 |
中国医学 | 86篇 |
肿瘤学 | 1004篇 |
出版年
2023年 | 138篇 |
2022年 | 119篇 |
2021年 | 629篇 |
2020年 | 374篇 |
2019年 | 582篇 |
2018年 | 721篇 |
2017年 | 449篇 |
2016年 | 467篇 |
2015年 | 604篇 |
2014年 | 881篇 |
2013年 | 1046篇 |
2012年 | 1735篇 |
2011年 | 1741篇 |
2010年 | 971篇 |
2009年 | 869篇 |
2008年 | 1475篇 |
2007年 | 1525篇 |
2006年 | 1336篇 |
2005年 | 1275篇 |
2004年 | 1099篇 |
2003年 | 918篇 |
2002年 | 911篇 |
2001年 | 153篇 |
2000年 | 101篇 |
1999年 | 127篇 |
1998年 | 153篇 |
1997年 | 113篇 |
1996年 | 63篇 |
1995年 | 84篇 |
1994年 | 86篇 |
1993年 | 66篇 |
1992年 | 79篇 |
1991年 | 70篇 |
1990年 | 53篇 |
1989年 | 53篇 |
1988年 | 49篇 |
1987年 | 37篇 |
1986年 | 41篇 |
1985年 | 35篇 |
1984年 | 41篇 |
1983年 | 38篇 |
1982年 | 42篇 |
1981年 | 36篇 |
1980年 | 21篇 |
1979年 | 18篇 |
1978年 | 29篇 |
1977年 | 27篇 |
1976年 | 19篇 |
1973年 | 18篇 |
1972年 | 15篇 |
排序方式: 共有10000条查询结果,搜索用时 421 毫秒
1.
2.
Antonio Montalvo Afonso Fernando Ruiz Juretschke Rosario González Rodrigálvarez Olga Mateo Sierra Begoña Iza Vallejo Roberto García Leal Marc Valera Melé Vicente Casitas Hernando Jose Manuel Hernández Poveda Carlos Fernández Carballal 《Neurocirugía (Asturias, Spain)》2021,32(1):1-9
Background and objectivesThe treatment of deafferentation pain by spinal DREZotomy is a proven therapeutic option in the literature. In recent years, use of DREZotomy has been relegated to second place due to the emergence of neuromodulation therapies. The objectives of this study are to demonstrate that DREZotomy continues to be an effective and safe treatment and to analyse predictive factors for success.Patients and methodsA retrospective study was conducted of all patients treated in our department with spinal DREZotomy from 1998 to 2018. Bulbar DREZotomy procedures were excluded. A visual analogue scale (VAS) and the reduction of routine medication were used as outcome variables. Demographic, clinical and operative variables were analysed as predictive factors for success.ResultsA total of 27 patients (51.9% female) with a mean age of 53.7 years underwent DREZotomy. The main cause of pain was brachial plexus injury (BPI) (55.6%) followed by neoplasms (18.5%). The mean time of pain evolution was 8.4 years with a mean intensity of 8.7 according to the VAS, even though 63% of the patients had previously received neurostimulation therapy. Favourable outcome (≥ 50% pain reduction in the VAS) was observed in 77.8% of patients during the postoperative period and remained in 59.3% of patients after 22 months average follow-up (mean reduction of 4.9 points). This allowed for a reduction in routine analgesic treatment in 70.4% of them. DREZotomy in BPI-related pain presented a significantly higher success rate (93%) than the other pathologies (41.7%) (p = .001). No association was observed between outcome and age, gender, DREZ technique, duration of pain or previous neurostimulation therapies. There were six neurological complications, four post-operative transient neurological deficits and two permanent deficits.ConclusionDorsal root entry zone surgery is effective and safe for treating patients with deafferentation pain, especially after brachial plexus injury. It can be considered an alternative treatment after failed neurostimulation techniques for pain control. However, its indication should be considered as the first therapeutic option after medical therapy failure due to its good long-term results. 相似文献
3.
José-Luis Andréu María Auxiliadora Martín Héctor Corominas José Javier Pérez-Venegas José Andrés Román-Ivorra Fernando Sánchez-Alonso Ángel Gil de Miguel 《Reumatología clinica》2021,17(4):212-214
IntroductionThe current paradigm of the management of rheumatoid arthritis (RA) recommends achieving a state of remission or low disease activity through the treat-to-target strategy. Our study assesses adherence to this strategy.MethodPatients with RA (ACR-EULAR 2010 criteria) were included. From each centre, 19 patients were randomly selected. Clinical histories (CH) were assessed by independent auditors, checking compliance with predefined quality criteria. The study was approved by ethics committees.ResultsWe included 856 patients (mean age 54 years; 71% women). The use of a combined index (CI) was recorded in 61% of cases. Visits were recorded every 4 weeks using a CI in 4% of CH while attempts were made to achieve remission. Monitoring of disease activity every 6–8 months after reaching the target was recorded in 73% of cases.ConclusionsThe implementation of the treat-to-target strategy is barely recorded in patients with RA in routine clinical practice. 相似文献
4.
5.
6.
Willy Baccaglini Felipe A. Glina Cristiano Linck Pazeto Luis G. Medina Fernando Korkes Wanderley M. Bernardo Rene Sotelo Sidney Glina Giancarlo Marra Marco Moschini Xavier Cathelineau Rafael Sanchez-Salas 《Clinical genitourinary cancer》2021,19(1):3-11.e1
This meta-analysis focuses on the accuracy of upgrading to clinically significant prostate cancer (PCa) by multiparametric magnetic resonance imaging-targeted biopsy (MRI-TB) versus systematic biopsy (SB). We searched the Medline, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, and Literatura Latino Americana em Ciências da Saúde databases through January 2020 for comparative, retrospective/prospective, paired-cohort, and randomized clinical trials with paired comparisons. The population consisted of patients with low-risk PCa in active surveillance with at least 1 index lesion on imaging. We evaluated the quality of evidence by using the Quality Assessment of Diagnostic Accuracy Studies-2 score. Group comparisons considered the differences between the area under the curve summary receiver operating characteristic curve in a 2-tailed method. We also compared the positive predictive value of the best single method (MRI-TB or SB) and the referral study test (combined biopsy, a combination of MRI-TB and SB). The meta-analysis included 6 studies enrolling 741 patients. The pooled sensitivity for the 2 groups was 0.79 (95% confidence interval, 0.74-0.83; I2 = 75%) and 0.67 (95% confidence interval, 0.63-0.74; I2 = 55.4%), respectively. The area under the curve for the MRI-TB and SB groups were 0.99 and 0.92 (P < .001), respectively. The positive predictive value for the MRI-TB and combined biopsy groups were similar. The accumulated evidence suggests better results for MRI-TB compared with SB. Therefore, use of MRI-TB alone may be preferable in patients in active surveillance harboring low-risk PCa. 相似文献
7.
Hajrunisa Cubro Karl A. Nath Sonja Suvakov Oscar Garcia-Valencia Santosh Parashuram Wendy M. White Tracey L. Weissgerber Meryl C. Nath Natasa M. Milic Fernando Sontag Livius V. d’Uscio Yi Zhu James L. Kirkland Tamar Tchkonia Mariam P. Alexander Reade A. Quinton Zvonimir S. Katusic Joseph P. Grande Vesna D. Garovic 《Kidney international》2021,99(3):646-656
8.
Macêdo Jéssica V. L. Frias Isaac A. M. Oliveira Maria D. L. Zanghelini Fernando Andrade César A. S. 《European journal of clinical microbiology & infectious diseases》2022,41(9):1191-1201
European Journal of Clinical Microbiology & Infectious Diseases - Rapid immunochromatographic tests are frequently used to diagnose dengue due to their easy use, low cost, and fast response. A... 相似文献
9.
Paula López-Sánchez José Portolés Leyre Martín Rodríguez Fernando Tornero Arturo José Ramos Martín-Vegue José Antonio Herrero Juan Luis Cruz Bermúdez 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2019,39(6):653-663
Introduction and objectivesChronic kidney disease has a high prevalence and economic impact, and an increased risk of hospitalization. Although there are public regional and country registries, we have not found references to estimate the impact of renal replacement therapy (RRT) on hospital admissions.MethodsWe obtained authorization from the ethics committee and health authorities to integrate the REMER [Madrid Kidney Disease Registry] (2013-2014) and Minimum Basic Data Set (2013-2015) databases and to analyze the admissions during the first year of RRT.Results767 patients started RRT in all the hospitals of our region across all RRT modalities. More than a third of the patients start dialysis during a hospital admission. This unplanned start, more common in HD than PD, shows relevant differences in patient profile or admission characteristics.Without considering this initial episode, almost 60% of patients were admitted during their first year. The hospitalization rate was 1.2 admissions/patient, higher in HD than in TX or PD; the mean length of stay was 8.6 days.The estimated cost of admissions during the first year is €12,006/patient. Our analysis ensures the exhaustive inclusion of all episodes and accurate estimation based on the discharge form.ConclusionThe impact of RRT on hospitals has been underestimated and is very relevant when calculating the total cost of RRT. Results from other countries cannot be extrapolated due to differences in the health system and patient profile. The integration of clinical databases could open up an opportunity that needs only institutional support for its development. 相似文献
10.
Gonzalo Canche-Escamilla Pamela Colli-Acevedo Rocio Borges-Argaez Patricia Quintana-Owen J. Fernando May-Crespo Mirbella Cáceres-Farfan Jesus Alejandro Yam Puc Pablo Sansores-Peraza Blanca Marina Vera-Ku 《Sustainable Chemistry and Pharmacy》2019
The present work focuses on the use of solid and agricultural residues from Aloe vera crops, as a source of antimicrobial agents and textile dyes. The roots from an A. vera plantation post-harvest were extracted with ethyl acetate, purified and phytochemically characterized to obtain five metabolites: aloesaponarin-I (1), deoxyerythrolaccin (2), lacaic acid D methyl ester (3), aloesaponarin-II (4), and aloesaponol-I (5). Acid hydrolysis of the solid industrial residue gave aloe-emodin (6) as the main product with a good yield. All of the components were tested for the first time against phytopathogenic bacteria strains, and deoxyerythrolaccin and lacaic acid D methyl ester were active against Xanthomonas campestris with MIC values of 46.86 and 93.75 μg/mL, respectively. Aloesaponarin-I and aloe-emodin, the main products, were tested as dyes for polyester fabrics using different mordants and pH bath conditions. The colour of each material was investigated in terms of the CIELAB L*, a* and b* values, and the colour fastness to light and washing was investigated according to the Mexican standard methods (NMX-A-074-INNTEX-2005; NMX-A-105-B02-INNTEX-2010). Aloesaponarin-I dyed polyester bright yellow but the final colour was very sensitive to the pH of the dye bath. Aloe-emodin dyed polyester deep yellow, and the fabrics showed good colour fastness to light and to domestic laundering. This study provides evidence that the phenolic components obtained from agricultural residues of the aloe industry can be useful organic alternatives as antimicrobial agents and textile dyes. 相似文献