排序方式: 共有26条查询结果,搜索用时 15 毫秒
1.
2.
肺表面活性物质(Pulmonary Surfactant,PS)主要由磷脂和脱辅基蛋白组成,它们在肺泡表面形成单分子膜,发挥降低肺泡表面张力的重要功能。已有一些研究表明,PS单分子表面膜的形成及其活性可以受到某些物质的干扰和抑制,现分别予以介绍。 1 蛋白质类抑制物人们很早就注意到血浆蛋白对PS的表面活性的抑制作用。1965年,Tierney等在提取兔PS的过程中加入全血或血清,结果使肺浸出液表面活性下降。接着,Cooper等在研究烫伤狗PS改变时证明血浆可以抑制肺灌洗液 相似文献
3.
目的:建立检测人血浆氧氟沙星的高效液相色谱法。方法:用φ为10%的三氯乙酸甲醇溶液处理血浆。色谱柱为Spherisorbc18(5μm,200×4.6mmI.D.);流动相为甲醇-水-10%四丁基溴化胺-85%磷酸(φ分别为25%、70%、5%、0.01%);体积流量(qv)为1.0ml·min-1;荧光检测激发波长为295nm,发射波长为505nm。结果:重复性试验示日内及日间相对标准差均小于5%。氧氟沙星的平均回收率为94.8%。结论:本法灵敏度高,重复性好,适用于药代动力学和临床研究。 相似文献
4.
5.
AIM: To study the serum level of flunarizine, a Ca~(2 ) channel blocker, we established a sensitive, accurate and efficient HPLC method. METHODS: A Shimadzu LC-6A HPLC general system was used. The column was 相似文献
6.
7.
8.
9.
Determination of Tinidazole in Human Plasma by RP-HPLC 总被引:1,自引:0,他引:1
采用反相高效液相色谱法测定人血浆替硝唑浓度。色谱柱为ShperisorbODS,紫外吸收检测波长为318nm。以甲硝唑为内标物。本法检测日内和日间相对标准偏差均小于7%。从血浆提取替硝唑的平均回收率为94.2%。 相似文献
10.
We studied the functional changes of pulmonary surfactant (PS) in acutelung injury models produced by endotoxin injection (E.coli O_(55)B_5) in rats.The sur-face properties of the lung lavage liquid and the total phospholipids (TPL) ex-tracted from it were assessed on a modified Wilhelmy film balance.γ-A isothermof the lavage liquid revealed an increase in minimum surface tension and a de-crease in hysteresis area,recruitment index and stability index,whereas that ofTPL extracted from it did not show any change except for hysteresis area.Thesurface activity correlates positively with the TPL content but negatively with thetotal protein content in the lavage liquid.The findings indicated that there was adysfunction of PS in rats with the lung injury induced by endotoxin,suggestingthat the function deficiency of PS might be caused by decreased phospholipidsand increased proteins in the alveoli. 相似文献