地方性慢性砷中毒调查报告

本文报告了新疆奎屯地区某厂由于饮高砷深井水引起的地方性慢性砷中毒的调查结果。该井水含砷浓度为0.6mg/L,是我国生活饮用水中最高容许浓度的15倍。该厂地方性慢性砷中毒的患病率是44.6％。本文描述了地方性慢性砷中毒的临床表现和病理变化。作者认为躯干部的砷色素增加夹杂淡白色色素减退斑点是典型的砷色素异常,手足部的点状角化和鸡眼样角化是典型的砷角化病。虽然病理变化无特异性和诊断性,但有一些特征性的改变有助于诊断。按照临床表现和病理变化,作者提出了地方性慢性砷中毒的诊断标准,以及因地制宜的防治措施,并扼要讨论了砷中毒的发病机理。     

地方性慢性砷中毒的皮肤表现(附317例临床及46例皮肤病理分析)

本文报道由于长期饮用地下高砷水而引起的地方性慢性砷中毒317例的临床表现,主要为皮肤病变,其中包括色素异常277例(占87.38％),角化病变226例(占70.66％),癌变5例(占1.58％)。在临床上,以躯干部出现棕褐色色素斑与淡白色斑点相夹杂的色素异常,手足出现点状或鸡眼状角化,以及躯干多发性癌变为特征。皮肤病理以良性砷角化为多见。本文简要讨论了发病机制及病理变化,并提出了地方性慢性砷中毒的诊断标准。     

ENDEMIC CHRONIC ARSENISM IN XINJIANG

This paper reports an investigation of endemic chronic arsenism due to drinking deep artesian well water in a plant in Kuitun Area, Xinjiang Uighur Autonomous Region. The 0.6 mg L arsenic concen tration of this water was 15 times the maximal per' missible concentration. In the plant, endemic chronic arsenism morbidity rate was 44.6To. The clinical features and histopathologic changes of this disease are described. The authors believe that areas of hyperpigmentation mixed with whitish depigmented spots are typical arsenic dyspigmentation, and that the spotted keratosis and corn-like keratosis palmaris et plantaris are typical arsenic keratosis although there are no standardly recognized specific diagnostic pathologic changes. These characteristic changes may aid in diagnosis.