The refinement of dose assessment of the THOR BNCT beam

A refined dose assessment method has been used now in the THOR BNCT facility, which takes into account more delicate corrections, carefully handled calibration factors, and the spectrum- and kerma-weighted k_t value. The refined method solved the previous problem of negative derived neutron dose in phantom at deeper positions. With the improved dose assessment, the calculated and measured gamma-ray dose rates match perfectly in a 15×15×15 cm³ PMMA phantom.     

Treatment of Stanford type A aortic dissection with triple pre-fenestration,reduced diameter,and three-dimensional-printing techniques: A case report

BACKGROUNDA 63-year-old female was diagnosed with acute Stanford type A aortic dissection. The patient had pain in the chest and back for 1 wk. The computed tomography angiography (CTA) showed Stanford type A aortic dissection (Myla type III aortic arch). The intimal tear was located at the top of the aortic arch and retrograded to the ascending aorta.CASE SUMMARYPreoperatively, a three-dimensional (3D)-printed model of the aortic arch was made according to CTA data. Then, under the guidance of the 3D-printed aortic model, a pre-fenestrated stent-graft was customized, and the diameter of the stent-graft was reduced intraoperatively by surgeons. 3D printing, triple pre-fenestration, and reduced diameter techniques were used during the surgery. The CTA examinations were performed at the 3^rd mo and 1st year after the surgery; the results showed that the aortic dissection was repaired without endoleak, and all three branches of the aortic arch remained unobstructed.CONCLUSIONApplying the triple pre-fenestration technique for aortic arch lesions was feasible and minimally invasive in our case. The technique provides a new avenue for thoracic endovascular aortic repair of Stanford type A aortic dissection.     

Total endovascular repair of an intraoperative stent-graft deployed in the false lumen of Stanford type A aortic dissection: A case report

BACKGROUND A 46-year-old male underwent ascending aortic replacement,total arch replacement,and descending aortic stent implantation for Stanford type A aortic dissection in 2016.However,an intraoperative stent-graft was deployed in the false lumen inadvertently.This caused severe iatrogenic thoracic and abdominal aortic dissection,and the dissection involved many visceral arteries.CASE SUMMARY The patient had pain in the chest and back for 1 mo.A computed tomography scan showed that the patient had secondary thoracic and abdominal aortic dissection.The ascending aortic replacement,total arch replacement,and descending aortic stent implantation for Stanford type A aortic dissection were performed 2 years prior.An intraoperative stent-graft was deployed in the false lumen.Endovascular aneurysm repair was performed to address this intractable situation.An occluder was used to occlude the proximal end of the true lumen,and a covered stent was used to direct blood flow back to the true lumen.A three-dimensional printing technique was used in this operation to guide prefenestration.The computed tomography scan at the 1stmo after surgery showed that the thoracic and abdominal aortic dissection was repaired,with all visceral arteries remaining patent.The patient did not develop renal failure or neurological complications after surgery.CONCLUSION The total endovascular repair for false lumen stent-graft implantation was feasible and minimally invasive.Our procedures provided a new solution for stent-graft deployed in the false lumen,and other departments may be inspired by this case when they need to rescue a disastrous stent implantation.     

痹祺胶囊对兔骨关节炎软骨代谢的作用研究

目的：观察痹祺胶囊对骨关节炎软骨代谢的作用。方法：以Hulth法复制兔膝骨关节炎模型,对软骨组织行Mankin标准评分,设置空白组、假手术组,观测各组兔血清及尿液的羟脯氨酸含量,并设痹祺胶囊低、中、高浓度组及西药组以了解其疗效。结果：各治疗组间Mankin标准评分水平无差异,痹祺胶囊各剂量组血清、尿羟脯氨酸含量与模型组比较差异均有显著意义（P〈0.05）。结论：痹祺胶囊可通过促进骨修复或抑制软骨破坏而减低兔骨关节炎模型体内羟脯氨酸含量,对骨关节炎软骨代谢有明确的改善作用。     

基因工程技术与中药药效评价

中药的创新与发展需要引入和采用最新的生物技术支持。以基因工程技术为核心的现代生物技术，为中药药效评价研究提供了新的思路和方法。本文从中药的药理作用及其机制和中药物质基础两个方面，分析了基因工程技术在中药药效评价领域的应用，并且对研究现状和存在的一些问题进行了探讨。     

Quality control and quality assurance procedures at the THOR BNCT facility

Various quality control (QC) and quality assurance (QA) procedures of the boron neutron capture therapy (BNCT) beam at the Tsing Hua Open-pool Reactor (THOR) are established to ensure beam availability and quality. The QC/QA methods mainly employ foil activation and paired ionization chambers, respectively, for beam intensity check and dose assessment. Beam intensity is monitored on-line by using three dead-time corrected fission chambers. In addition to the periodic QC/QA activities regarding beam quality and the monitoring system, the quick QC/QA performed in an all-in-one phantom will be executed less than 70 min before the clinical treatment to guarantee beam quality. The QC/QA procedures have been gradually established and the actual performance satisfied the preset criteria defined for the BNCT facility at THOR.     

基于临床调查的针灸门诊适宜病症研究

目的:调查中国现阶段针灸门诊治疗病种现状,为针灸适宜病症的确立提供临床依据.方法:通过整群多级随机抽样对2008年全国31个省具有代表性的医院针灸门诊接受治疗的患者进行调查研究,基于帕累托法则和EpiMap软件进行病症分类和分布分析.结果:获得36家医院针灸门诊首诊患者31858例,涉及病症种类368种16个疾病系统,其中最常见病症57种,常见病症60种,少见病症251种.结论:依据本次调查显示现阶段针灸门诊适宜病症368种,各行政区病症种类数量分布不均衡,针灸优势病症系统聚集度高,应加大推广普及针灸适宜病症的应用.     

Transarterial embolization in the management of life-threatening hemorrhage after maxillofacial trauma: a case report and review of literature

There are many reasons for hypotension in trauma patients. Life-threatening hemorrhage associated with maxillofacial trauma is considered rare. Here, we present a 25-year-old patient with maxillofacial trauma complicated by life-threatening hemorrhage after a traffic accident. At the emergency department, massive epistaxis was noted. Nasal packing and blood transfusion were performed, but vital signs of the patient were still unstable. Cerebral angiography revealed contrast extravasation from the left superficial temporal and internal maxillary arteries of the left external carotid artery. After transarterial embolization was performed, the hemorrhage immediately stopped. When common treatment such as nasal packing, correction of coagulopathy, reduction of fractures, and arterial ligation fails to control the hemorrhage, transarterial embolization can offer a safe alterative to surgical exploration.