全文获取类型
收费全文 | 52431篇 |
免费 | 3291篇 |
国内免费 | 273篇 |
专业分类
耳鼻咽喉 | 661篇 |
儿科学 | 1343篇 |
妇产科学 | 1090篇 |
基础医学 | 7792篇 |
口腔科学 | 3144篇 |
临床医学 | 4453篇 |
内科学 | 11405篇 |
皮肤病学 | 1347篇 |
神经病学 | 4510篇 |
特种医学 | 1250篇 |
外科学 | 5326篇 |
综合类 | 173篇 |
一般理论 | 16篇 |
预防医学 | 5201篇 |
眼科学 | 895篇 |
药学 | 3619篇 |
中国医学 | 326篇 |
肿瘤学 | 3444篇 |
出版年
2023年 | 502篇 |
2022年 | 492篇 |
2021年 | 1853篇 |
2020年 | 1329篇 |
2019年 | 1684篇 |
2018年 | 2021篇 |
2017年 | 1393篇 |
2016年 | 1614篇 |
2015年 | 1814篇 |
2014年 | 2444篇 |
2013年 | 3059篇 |
2012年 | 4400篇 |
2011年 | 4812篇 |
2010年 | 2518篇 |
2009年 | 2049篇 |
2008年 | 3463篇 |
2007年 | 3423篇 |
2006年 | 3074篇 |
2005年 | 2759篇 |
2004年 | 2482篇 |
2003年 | 2124篇 |
2002年 | 1876篇 |
2001年 | 580篇 |
2000年 | 492篇 |
1999年 | 470篇 |
1998年 | 264篇 |
1997年 | 221篇 |
1996年 | 181篇 |
1995年 | 178篇 |
1994年 | 153篇 |
1993年 | 128篇 |
1992年 | 233篇 |
1991年 | 211篇 |
1990年 | 154篇 |
1989年 | 183篇 |
1988年 | 135篇 |
1987年 | 92篇 |
1986年 | 124篇 |
1985年 | 106篇 |
1984年 | 109篇 |
1983年 | 94篇 |
1982年 | 65篇 |
1981年 | 53篇 |
1980年 | 51篇 |
1979年 | 69篇 |
1978年 | 44篇 |
1977年 | 37篇 |
1976年 | 43篇 |
1973年 | 37篇 |
1971年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Mahmut Gümüş MD Chieh-I Chen MPH Cristina Ivanescu PhD Saadettin Kilickap MD Igor Bondarenko MD Mustafa Özgüroğlu MD Miranda Gogishvili MD Haci M. Turk MD Irfan Cicin MD James Harnett PharmD Vera Mastey MS Ulrike Naumann MS Matthew Reaney MS Gerasimos Konidaris MS Medha Sasane PhD Keri J. S. Brady PhD Siyu Li PhD Giuseppe Gullo MD Petra Rietschel MD Ahmet Sezer MD 《Cancer》2023,129(1):118-129
2.
Boothe Emily Olenderek Marta Noyola M. Cristina Rushing Julia Allred Erinn Kaplan Sebastian 《Zeitschrift fur Gesundheitswissenschaften》2022,30(6):1373-1380
Journal of Public Health - Group prenatal care provides an alternative model of prenatal care that allows for collaboration with peers, education, discussion, and self-management training in... 相似文献
3.
4.
Chalub Lucas Orbolato Nunes Gabriel Pereira Ferrisse Túlio Morandin Strazzi-Sahyon Henrico Badaoui Dos Santos Paulo Henrique Gomes-Filho João Eduardo Cintra Luciano Tavares Angelo Sivieri-Araujo Gustavo 《Clinical oral investigations》2022,26(4):3343-3356
Clinical Oral Investigations - The objective of this systematic review and meta-analysis (SRM) was to answer the question whether the use of ultrasonic irrigation (UI) results in less postoperative... 相似文献
5.
6.
Thomas Heisser Rafael Cardoso Tobias Niedermaier Michael Hoffmeister Hermann Brenner 《International journal of cancer. Journal international du cancer》2023,152(5):952-961
Screening colonoscopy for early detection and prevention of colorectal cancer (CRC) is mostly used inefficiently. Here, we assessed the potential of an innovative approach to colonoscopy-based screening, by use of a single, low threshold fecal immunochemical test (FIT) as a “gateopener” for screening colonoscopy. Using COSIMO, a validated simulation model, we modeled scenarios including either direct invitation to screening colonoscopy or an alternative approach involving mailing a single (“gateopener”) FIT along with an invitation to colonoscopy contingent on a FIT value above a low threshold yielding a 50% positivity rate (ie, every other pretest will be positive). Under plausible assumptions on screening offer adherence, we found that such “gateopener screening” (use of screening colonoscopy contingent on a positive, low threshold gateopener FIT) approximately doubled cancer detection rates vs conventional screening. In those spared from screening colonoscopy due to a negative gateopener FIT pretest, numbers needed to screen were 10-times higher vs those for individuals with a positive FIT, peaking in >2000 and >3800 (hypothetically) needed colonoscopies to detect one case of cancer in men and women, respectively. Gateopener screening resulted in 42%-51% and 59%-65% more prevented CRC cases and deaths, respectively. In summary, by directing colonoscopy capacities to those most likely to benefit, offering screening colonoscopy contingent on a “gateopener” low-threshold FIT would substantially enhance efficiency of colonoscopy screening. 相似文献
7.
8.
Adriana Cunha VargasCatia Dell AgnoloWillian Augusto de MeloFernando Castilho PellosoLander dos SantosMaria Dalva de Barros CarvalhoSandra Marisa Pelloso 《Asian Pacific journal of cancer prevention》2020,21(1):55-62
Objective: This study aimed to analyze the trend in cervical cancer (ICD C53) mortality in Brazilian regions in women who are who are screened and not screened from 1996 to 2015. Methods: An epidemiological study, of time series of mortality from cervical cancer performed in 90,856 women under 24 years old (343 women), between 25 and 64 years old (32,703 women), and over 65 years old (10,909 women). The data from this research were collected from the DATASUS, from the SIM Health Surveillance Secretariat files, captured through TABNET selecting the resident population by gender and age group and ICD 10 C53 from 1996 to 2015. Results: Among women, 43.8% were white, and 76% had less than eight years of formal education. Polynomial regression showed an increasing trend in cervical cancer mortality in Brazil for women aged 15 - 24 years (p=0.01). Between 25 - 64 and 65 years or older it remained constant, but high (p=0.07; 0.99). The Northeast region pointed a growing trend in women aged 15 to 24 (p=0.01), 25 to 64 years (p=0.01) and 65 or older (p=0.001). The Northeast presented the highest average growth per year. In the Southeast, South and Midwest regions, decreasing trends were observed despite the high rates. The Joinpoint regression showed a 95% confidence interval, and that mortality from cervical cancer in the North region increased throughout the period analyzed. an increasing trend was observed from 1996 to 1998, whereas in the Midwest region, the trend remained stable throughout the period analyzed. The Federal District presented an upward trend from 1996 to 2015. In Brazil, an upward trend was observed throughout the whole period analyzed. Conclusions: Cervical cancer mortality in younger women is becoming more predominant, in addition to the high rate observed for women aged 65 or older. 相似文献
9.
Glutathione S-transferase Polymorphisms in Head and Neck Squamous Cell Carcinoma Treated with Chemotherapy and/or Radiotherapy 下载免费PDF全文
Mauricio Pereira ManigliaAnelise RussoPatrícia Matos Biselli-ChicoteJuliana Garcia de Oliveira-CucoloGabriela Helena Rodrigues-Flemingjosé Victor -ManigliaÉrika Cristina PavarinoEny Maria Goloni-Bertollo 《Asian Pacific journal of cancer prevention》2020,21(6):1637-1644
Background/Aim: The Glutathione S-transferases (GSTs) are important carcinogen-metabolizing enzymes. Polymorphisms involved in these enzymes can modulate the development and treatment of head and neck cancer. To investigate the association of GSTs polymorphisms with head and neck cancer and risk factors, clinical-pathological features, and survival time of the patients treated with chemotherapy and/or radiotherapy. Methods: The GST gene polymorphisms were evaluated in 197 cases and 514 controls by PCR-RFLP-Polymerase Chain Reaction Restriction Fragment Length Polymorphism. Results: The GSTP-313 was associated with a decreased risk for HNSCC (p=0.050). The GSTP1 haplotype analysis revealed a higher frequency of the AC and AT haplotypes in the case group than in the control group (p=0.013 and p=0.019, respectively), and the opposite for G-C haplotype (p = 0.015). Yet, the different combinations between the genotypes were associated with an increased risk of cancer. The study showed no association between the polymorphisms and primary tumor site, clinical-pathological characteristics, treatment (chemotherapy and/or radiotherapy) and survival time of the patients. Conclusion: The GST polymorphisms combination showed an increased risk for carcinogenesis, and studies with larger casuistry can contribute to the clarification of the role in individual patient differences for the response to chemotherapy and/or radiotherapy and identify biomarkers of susceptibility. 相似文献