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高容量血液滤过对MODS猪肺TNF-α和 IL-8mRNA表达的影响 总被引:1,自引:1,他引:0
目的:探讨高容量血液滤过(HVHF)后多器官功能障碍综合征(MODS)猪肺组织TNF-α、IL-8 mRNA表达水平的变化及意义.方法:雄性家猪25只,随机分为模型组(n=9)、滤过组(n=10)、对照组(n=6),前二组采用二次打击法建立MODS模型,滤过组采用HVHF治疗3d,对照组不作处理.测定各器官功能相关指标,实时荧光定量RT-PCR技术定量法检测肺组织TNF-α、IL-8 mRNA表达水平.结果:滤过组滤过后各器官功能有关指标水平均有不同程度的改善,器官衰竭发生率、动物病死率较模型组明显降低(20.0% vs 88.9%,20.0% vs 77.8%,P<0.05);滤过组TNF-α mRNA、IL-8 mRNA表达水平较模型组明显降低[(0.1042±0.0158) vs (0.1235±0.0188),P<0.01;(0.1458 0.0199) vs (0.1991±0.0519),P<0.05].结论:HVHF早期应用可以降低创伤引起的肺组织TNF-α和 IL-8 mRNA表达,表达水平与肺损伤的程度和肺衰竭发生率相关;同时可减少肺损伤,减少肺衰竭的发生. 相似文献
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Objective: To improve the prognosis of patients with abdominal trauma.
Methods: Between January 1993 and December 2005, 415 patients were enrolled in this research. The patients consisted of 347 males and 68 females with mean age of 36 years (ranging from 3-82 years). All abdominal traumas consisted of closed traumas (360 cases, 86.7%) and open traumas (55 cases, 13.3%).Results: A total of 407 cases (98.1%) were fully recov- ered from trauma and the other 8 cases (1.9%) died of mul- tiple injuries. The mean injury severity score (ISS) of all patients was 22 while the mean ISS of the patients who died in hospital was 42. Postoperative complications were seen in 9 patients such as infection of incisional wounds (6 cases), pancreatic fistula (2 cases) and intestinal fistula (1 case). All these postoperative complications were cured by the conservative treatment. Conclusion: Careful case history inquisition and physical examination are the basic methods to diagnose abdominal trauma. Focused abdominal ultrasonography is always the initial imaging examination because it is non-invasive and can be performed repeatedly with high accuracy. The doctors should consider the severity of local injuries and the general status of patients during the assessment of abdominal trauma. The principle of treatment is to save lives at first, then to cure the injuries. Unnecessary laparotomy should be avoided to reduce additional surgical trauma. 相似文献
Methods: Between January 1993 and December 2005, 415 patients were enrolled in this research. The patients consisted of 347 males and 68 females with mean age of 36 years (ranging from 3-82 years). All abdominal traumas consisted of closed traumas (360 cases, 86.7%) and open traumas (55 cases, 13.3%).Results: A total of 407 cases (98.1%) were fully recov- ered from trauma and the other 8 cases (1.9%) died of mul- tiple injuries. The mean injury severity score (ISS) of all patients was 22 while the mean ISS of the patients who died in hospital was 42. Postoperative complications were seen in 9 patients such as infection of incisional wounds (6 cases), pancreatic fistula (2 cases) and intestinal fistula (1 case). All these postoperative complications were cured by the conservative treatment. Conclusion: Careful case history inquisition and physical examination are the basic methods to diagnose abdominal trauma. Focused abdominal ultrasonography is always the initial imaging examination because it is non-invasive and can be performed repeatedly with high accuracy. The doctors should consider the severity of local injuries and the general status of patients during the assessment of abdominal trauma. The principle of treatment is to save lives at first, then to cure the injuries. Unnecessary laparotomy should be avoided to reduce additional surgical trauma. 相似文献
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中性粒细胞凋亡在高容量血液滤过防治多器官功能障碍中的变化及意义 总被引:6,自引:2,他引:4
多器官功能障碍综合征(MODS)是重症监护室患者死亡的主要原因之一。我们在建立猪MODS模型的基础上,采用高容量血液滤过(HVHF)防治MODS.通过观察中性粒细胞(PMN)凋亡在HVHF防治MODS中的变化及意义,为临床HVHF防治MODS提供新的实验依据。 相似文献
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目的探讨高容量血液滤过(HVHF)防治家猪多器官功能障碍(MODS)对主要炎症细胞:中性粒细胞及淋巴细胞凋亡的影响。方法19头猪采用失血性休克+复苏灌注+内毒素血症复制MODS模型,随机分为HVHF组(n=10)和MODS组(n=9)。采用酶联免疫吸附试验(EUSA)法检测血清白细胞介素(IL)-1β、IL-10浓度;采用流式细胞仪检测中性粒细胞(PMN)及淋巴细胞的凋亡。结果HVHF组治疗后IL-1β浓度明显下降;治疗开始后IL-10明显下降,6h达到最低点,此后维持在稳定状态。HVHF组治疗后,中性粒细胞凋亡率增加,而淋巴细胞凋亡率下降。HVHF组各主要器官功能均明显改善,动物死亡率和MODS发生率显著低于MODS组。结论高容量血液滤过能有效降低血浆细胞因子水平,进而加速了中性粒细胞的凋亡,抑制了淋巴细胞凋亡,在一定程度上恢复了机体的免疫平衡,从而对MODS起到防治作用。 相似文献
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Kugel疝修补术是一种非腹腔镜下腹膜前的微创手术。我院从2003年10月至今用此新的手术方法治疗了腹股沟疝64例,现报告如下。[第一段] 相似文献
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早期乳腺癌保乳手术30例临床分析 总被引:1,自引:0,他引:1
随着对乳腺癌生物学特性更深入的认识,20世纪80年代以来保乳手术在乳腺癌的手术治疗中逐渐流行起来.我院1990年以来收治的乳腺癌患者中有30例行保乳手术.现将其临床资料分析报道如下. 相似文献
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