土家医药半结构化数据的功效挖掘及可视化研究＊

目的 利用数据挖掘技术对半结构化数据的土家族医药进行品种规范和常用功效的可视化发现。方法 收集整理《中国民族药辞典》、《土家医方剂学》等土家族代表性医药文献，建立土家族医药原始数据库，包含药物拉丁学名、药用部位、性味、毒性、功效、主治疾病等。借助Visual FoxPro 9.0软件对土家族医药特性进行频次统计和品种规范，主要以法定标准收录；借助TCMISS (V2.5)、Cytoscape3.6.1、Gephi0.9.2等软件对土家药“药物-功效-主治”间的语义关系，进行功效挖掘和可视化展示。结果 筛选土家药共1453味，方剂共771首，其中土家药主要以“寒（凉）、平”性偏多，苦味药频次最高，其次是辛味药、甘味药；清热败毒、赶风除湿等功效出现频次最高；皮肤疮癣、妇科疾病等是关联程度较大的主治病症。结论 土家族医药的品种规范和“药性-药味-功效-主治”隐形关系可视化分析，可为完善土家药信息化研究奠定基础。     

Quantification of in vivo gastric fluid volume in Bama miniature pigs in fasted state

Although the study of bioequivalence waivers in humans is already well‐established, their application and translation into animals, which are complicated by differences in physiology, have only recently become subjects of interest. The main purpose of this paper is to quantify the liquid volume affecting drug dissolution in pig stomachs. We used magnetic resonance imaging (MRI) to scan 18 Bama miniature pigs weighing 15, 30 or 50 kg. Amira 6.0.1 software was used for 3D image processing. We found that the gastric fluid volume had a linear relationship with the weight of pig (R² = 0.9935) over this weight range. The pig weight, therefore, could be used as a surrogate for the fasted gastric fluid volume. After combining data of gastric fluid secretion and drinking water volumes, our results could be used as a reference for the evaluation of oral drug absorption in pigs.     

Dosimetric analysis of tomotherapy-based intensity-modulated radiotherapy with and without bone marrow sparing for the treatment of cervical cancer

Objective The aim of the study was to compare tomotherapy-based bone marrow-sparing intensity-modulated radiotherapy(BMS-IMRT) with intensity-modulated radiotherapy(IMRT) without entering the pelvic bone marrow as a planning constraint in the treatment of cervical cancer after hysterectomy. Methods BMS-IMRT and IMRT plans were designed for a cohort of nine patients. The prescribed dose was 45 Gy in 1.8 Gy daily fractions, and 95% of the planned target volume received this dose. The doses were computed using a commercially available treatment planning system with the convolution/superposition algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices(HI and CI) as well as organ at risk dose and volume parameters. Results BMS-IMRT had advantages over IMRT in terms of CI, but was equivalent to the latter in HI. V5, V10, V20, V30, and V40 of pelvic bone marrow in BMS-IMRT decreased by 0.06%, 17.33%, 22.19%, 13.85%, and 16.46%, respectively, compared with IMRT. Except for V30 of the small bowel and V30 and V40 of the bladder, no statistically significant differences were found between BMS-IMRT and IMRT in the small bowel, bladder, and rectum. Conclusion For cervical cancer patients receiving tomotherapy-based radiotherapy after hysterectomy, BMS-IMRT reduced pelvic bone marrow volume receiving low-dose radiation, and it may be conducive to preventing acute hematologic toxicity.     

丹珍头痛胶囊治疗慢性紧张性头痛疗效观察

目的观察丹珍头痛胶囊治疗慢性紧张性头痛的疗效。方法将门诊就诊的138例慢性紧张性头痛患者按随机数字表法分为对照组和试验组,对照组给予文拉法辛缓释胶囊,试验组在对照组治疗的基础上加用丹珍头痛胶囊治疗并观察4周。评估两组患者临床疗效,使用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评估抑郁、焦虑情况。结果试验组总有效率为90.67%,对照组总有效率为76.19%,两组相比,差异有统计学意义(P<0.05)。试验组治疗后2周、4周HAMA评分、HAMD评分均较治疗前降低。与对照组比较,在各个时间点HAMA评分、HAMD评分均明显降低,差异有统计学意义(P<0.05)。结论丹珍头痛胶囊可明显改善慢性紧张性头痛患者的头痛程度及焦虑、抑郁障碍。     

腹内疝的MSCT表现和征象分析

目的:分析总结腹内疝的多层螺旋CT(MSCT)表现和征象特点,提高对本病的认识和术前诊断的准确性。材料与方法:回顾性分析经手术证实的12例腹内疝患者的MSCT影像资料。结果:12例患者术前CT检查中5例诊断考虑为腹内疝。术后证实12例患者均为腹内疝,其中腹部术后粘连束带疝4例,十二指肠旁疝3例,网膜疝1例,肠系膜裂孔疝2例,乙状结肠周围疝1例,吻合口后疝1例。腹内疝主要的CT表现为:肠梗阻(100%),肠系膜血管走行异常(83.33%),占位效应(66.67%),肠袢绞窄坏死、肠壁缺血水肿(50%),疝口(41.67%);各类型腹内疝的相关CT表现与手术所见无显著性差异(P0.05)。结论:腹内疝的MSCT表现具有一定的特征性,认识和掌握这些特征,有助于提高术前诊断的准确性。     

Prediction of diagnosis results of rheumatoid arthritis patients based on autoantibodies and cost-sensitive neural network

Clinical Rheumatology - To analyze and evaluate the effectiveness of the detection of single autoantibody and combined autoantibodies in patients with rheumatoid arthritis (RA) and related...     

无牙颌患者全口义齿满意度调查

目的 调查患者对全口义齿修复效果的主观评价，并探讨各种因素对全口义齿满意度的影响。方法 在保证全口义齿质量的条件下，采用全口义齿满意度问卷对７４例无牙颌患者进行调查分析。结果 外观满意度比语音、咀嚼功能、固位功能、舒适性等方面满意度高；下颌固位满意度比上颌差。结论 全口义齿不仅要提高技术质量，也要重视患者的心理因素、人文因素等。     

脉冲电磁场结合自体红骨髓移植治疗创伤性骨缺损的疗效

 目的 探讨脉冲电磁场(pulsed electromagnetic fields,PEMFs)结合自体红骨髓移植治疗骨缺损的疗效。方法 将四肢新鲜骨折患者随机分为3组,对照组手术过程中植入同种异体骨后行内固定,2 Hz、15 Hz治疗组植入同种异体骨与自体红骨髓复合体后内固定,术后分别配合2 Hz、15 Hz脉冲电磁场治疗;3组患者分别于术后4、12、24、40周复查X线片并进行疗效评定。结果 30例患者治疗后均获得随访,对照组、2 Hz、15 Hz治疗组治愈率分别为80%、100%、90%;在相同时间点上,治疗组骨痂生长情况明显优于对照组(P<0.05);2 Hz治疗组骨痂生成较15 Hz治疗组明显增多(P<0.05);3种治疗方式下肢体的功能恢复情况差异无统计学意义(P>0.05)。结论 联合运用脉冲电磁场、自体红骨髓复合同种异体骨移植能明显促进骨痂生长,修复骨缺损有显著效果。