带气囊导管构建脊髓缺血模拟再灌注与缺血分离模型

背景:采用带有气囊的导管急性压迫脊髓缺血模拟人类损伤可以造成再灌注与缺血分离的动物模型。目的:应用免疫组化和生物化学分析方法观察不同缺血时间窗处理对损伤脊髓的影响。方法:SD大鼠36只,随机分为假手术组,带气囊导管造成大鼠脊髓缺血10,30,45,60,90min组。结果与结论:再灌注48h后,随着缺血时间的延长,脊髓前角神经元坏死和凋亡逐渐加重,丙二醛水平逐渐增加,超氧化物歧化酶活性逐渐下降,大鼠的神经行为学病症加重。提示用带气囊的导管建立缺血再灌注大鼠模型成功,再灌注后大鼠脊髓的损伤随缺血时间的延长而加重。     

肱骨干骨不连固定方法进展

骨不连是肱骨干骨折后常见并发症之一,发生率因治疗方法不同而异.固定不稳和骨折端分离可能是引起肱骨干骨不连的主要原因.手术是目前治疗肱骨干骨不连的首选方法.常用的固定方法如钢板、髓内钉和外固定支架在治疗肱骨干骨不连上何者更具优越性,尚存在争议.钢板固定治疗骨不连愈合率高,肩痛发生率低.髓内钉固定可减少软组织剥离,降低桡神经损伤和感染危险.对初次髓内钉固定失败患者,钢板更有优越性,单纯更换髓内钉治疗几乎没有效果.Ilizarov外固定技术可用于节段性骨缺损、感染、畸形和多次治疗失败的骨不连病例.必须依据个体化原则选择手术方案,尽可能避免潜在风险.     

前置钢板微创固定治疗肱骨干中下段骨折的可行性研究

Objective To evaluate effects of minimal invasive plating for treatment of mid-distal humeral shaft fractures.Methods From May 2004 to December 2007, 20 patients with isolated unilat-eral mid-distal third humeral shaft fractures were surgically treated with close reduction and internal fixation using a 4.5 mm dynamic compression plate which was anteriorly inserted through 2 small incisions on the anterior aspects of proximal and distal parts of the arm, away from the fracture site.The postoperative function of the radial nerve and the musculocutaneous nerve, the postoperative alignment of the main fragments on the anteroposterior radiographs, the bone healing time and muscle strength of biceps muscles were measured and recorded, Results Four patients complained of numbness at the area innervated by the lateral ante-braehial cutaneous nerve in the affected forearm after the surgery.No signs of iatrogenic radial nerve palsies occurred after the surgery.A completely normal alignment was achieved in 7 patients, but varus of 11° was found in 2 cases and varus of 2°, 3°, 4°, 5°, 6°, 7° and 10° in one each.Valgus deformity was noticed in 4 cases, and valgus of 3°, 4°, 6° and 7° in one each.The mean follow-up of 10.4 months for 19 patients re-vealed bony union of all the fractures.The average bone healing time was 13.4 weeks.At the latest follow-up, the biceps muscle strength of all the patients was 5 degrees.Hardwires were removed in 5 patients without any complications.Conclusions Minimally invasive anterior plating is a safe alternative osteosynthesis for mid-distal third humeral shaft fractures.However, this technique may interfere with the function of the lateral antebrachial cutaneous nerve.     

前置钢板微创固定治疗肱骨干中下段骨折的可行性研究

Objective To evaluate effects of minimal invasive plating for treatment of mid-distal humeral shaft fractures.Methods From May 2004 to December 2007, 20 patients with isolated unilat-eral mid-distal third humeral shaft fractures were surgically treated with close reduction and internal fixation using a 4.5 mm dynamic compression plate which was anteriorly inserted through 2 small incisions on the anterior aspects of proximal and distal parts of the arm, away from the fracture site.The postoperative function of the radial nerve and the musculocutaneous nerve, the postoperative alignment of the main fragments on the anteroposterior radiographs, the bone healing time and muscle strength of biceps muscles were measured and recorded, Results Four patients complained of numbness at the area innervated by the lateral ante-braehial cutaneous nerve in the affected forearm after the surgery.No signs of iatrogenic radial nerve palsies occurred after the surgery.A completely normal alignment was achieved in 7 patients, but varus of 11° was found in 2 cases and varus of 2°, 3°, 4°, 5°, 6°, 7° and 10° in one each.Valgus deformity was noticed in 4 cases, and valgus of 3°, 4°, 6° and 7° in one each.The mean follow-up of 10.4 months for 19 patients re-vealed bony union of all the fractures.The average bone healing time was 13.4 weeks.At the latest follow-up, the biceps muscle strength of all the patients was 5 degrees.Hardwires were removed in 5 patients without any complications.Conclusions Minimally invasive anterior plating is a safe alternative osteosynthesis for mid-distal third humeral shaft fractures.However, this technique may interfere with the function of the lateral antebrachial cutaneous nerve.     

锁定接骨板治疗肱骨近端三、四部分骨折

背景:锁定接骨板是一种新型的内固定钢板,可以改善肱骨近端骨折的临床治疗效果。目的:探讨锁定接骨板置入内固定治疗肱骨近端三、四部分骨折疗效以及并发症的发生情况。方法:回顾性分析复旦大学附属中山医院青浦分院骨科2008年1月至2009年12月行锁定接骨板内固定治疗31例肱骨近端骨折患者临床资料,其中男13例,女18例;年龄28-81岁,平均56.4岁。骨折类型采用Neer分类,三部分骨折19例,四部分骨折12例。内固定治疗采用胸大肌三角肌间沟入路,行肱骨近端锁定接骨板内固定术。另外,检索锁定接骨板治疗肱骨近端三、四部分骨折并发症的相关研究文献,对并发症的发生情况进行研究分析。综合分析临床病例疗效与检索文献中并发症的发生情况,获得锁定接骨板治疗肱骨近端三、四部分骨折的特点。结果与结论:复旦大学附属中山医院青浦分院骨科应用锁定接骨板内固定治疗31例患者均得到13-49个月随访,平均随访19.8个月。骨折均愈合,无内固定失效,临床愈合时间为8-16周。根据Constant评分标准评定肩关节功能,其中优11例,良16例,可3例,差1例。锁定接骨板内固定是治疗肱骨近端三、四部分骨折可靠有效的方法。但也可发生螺钉松动、肱骨头坏死等相关并发症,因此,内固定治疗操作时应注意保护肱骨头血运,复位肱骨颈内侧骨折块并牢固固定,以减少并发症的发生,提高内固定治疗疗效。     

前置钢板微创固定治疗肱骨干中下段骨折的可行性研究

Objective To evaluate effects of minimal invasive plating for treatment of mid-distal humeral shaft fractures.Methods From May 2004 to December 2007, 20 patients with isolated unilat-eral mid-distal third humeral shaft fractures were surgically treated with close reduction and internal fixation using a 4.5 mm dynamic compression plate which was anteriorly inserted through 2 small incisions on the anterior aspects of proximal and distal parts of the arm, away from the fracture site.The postoperative function of the radial nerve and the musculocutaneous nerve, the postoperative alignment of the main fragments on the anteroposterior radiographs, the bone healing time and muscle strength of biceps muscles were measured and recorded, Results Four patients complained of numbness at the area innervated by the lateral ante-braehial cutaneous nerve in the affected forearm after the surgery.No signs of iatrogenic radial nerve palsies occurred after the surgery.A completely normal alignment was achieved in 7 patients, but varus of 11° was found in 2 cases and varus of 2°, 3°, 4°, 5°, 6°, 7° and 10° in one each.Valgus deformity was noticed in 4 cases, and valgus of 3°, 4°, 6° and 7° in one each.The mean follow-up of 10.4 months for 19 patients re-vealed bony union of all the fractures.The average bone healing time was 13.4 weeks.At the latest follow-up, the biceps muscle strength of all the patients was 5 degrees.Hardwires were removed in 5 patients without any complications.Conclusions Minimally invasive anterior plating is a safe alternative osteosynthesis for mid-distal third humeral shaft fractures.However, this technique may interfere with the function of the lateral antebrachial cutaneous nerve.     

股骨远端LISS钢板治疗股骨远端粉碎性骨折

目的:总结股骨远端LISS钢板治疗股骨远端粉碎骨折的临床效果。方法:8例股骨远端粉碎性骨折采用股骨远端LISS钢板微创内固定系统进行固定,远端粉碎骨折块配合松质骨拉力螺钉固定。骨折按AO/ASIF分类:A3型1例,C2型5例,C3型2例。结果:平均随访15个月,7例骨折正常愈合,1例延迟愈合,平均骨折愈合时间为4个月;按Kolmenrt评定标准:本组优5例,良2例,一般1例,优良率92.2%。膝关节活动度90-120度,平均膝关节活动度105度。结论:股骨远端LISS钢板可有效治疗股骨远端粉碎性骨折,具有固定牢固、骨折愈合率高、创伤小,并发症少等优点。     

益赛普治疗难治性强直性脊柱炎临床疗效分析

目的:探究难治性强直性脊柱炎应用益赛普短期治疗的临床疗效。方法:择取2012年6月~2013年6月我院收治的难治性强直性脊柱炎患者32例,所有患者均应用非甾体抗炎药及改善病情的药物治疗至少1年,疗效欠佳改用益赛普治疗,连续治疗3个月,评判其临床疗效。结果:患者的晨僵时间、CRP、ESR、全身动关节及腰椎活动度、胸廓扩张度、枕壁距等各项指标均明显改善,且无严重的不良反应发生。结论:难治性强直性脊柱炎应用益赛普短期治疗,对于病情的控制具有一定的效果。