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1.
Guanghui Han Xiabi Liu Guangyuan Zheng Murong Wang Shan Huang 《Medical & biological engineering & computing》2018,56(12):2201-2212
Ground-glass opacity (GGO) is a common CT imaging sign on high-resolution CT, which means the lesion is more likely to be malignant compared to common solid lung nodules. The automatic recognition of GGO CT imaging signs is of great importance for early diagnosis and possible cure of lung cancers. The present GGO recognition methods employ traditional low-level features and system performance improves slowly. Considering the high-performance of CNN model in computer vision field, we proposed an automatic recognition method of 3D GGO CT imaging signs through the fusion of hybrid resampling and layer-wise fine-tuning CNN models in this paper. Our hybrid resampling is performed on multi-views and multi-receptive fields, which reduces the risk of missing small or large GGOs by adopting representative sampling panels and processing GGOs with multiple scales simultaneously. The layer-wise fine-tuning strategy has the ability to obtain the optimal fine-tuning model. Multi-CNN models fusion strategy obtains better performance than any single trained model. We evaluated our method on the GGO nodule samples in publicly available LIDC-IDRI dataset of chest CT scans. The experimental results show that our method yields excellent results with 96.64% sensitivity, 71.43% specificity, and 0.83 F1 score. Our method is a promising approach to apply deep learning method to computer-aided analysis of specific CT imaging signs with insufficient labeled images. 相似文献
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[目的]观察滋肾宁神胶囊对D-半乳糖所致亚急性衰老模型大鼠的影响.[方法]选用SD大鼠随机分成空白对照组,模型组,七宝美髯丸组(剂量为2 g·kg-1·d-1),滋肾宁神丸组(剂量为3.33 g·kg-1·d-1),滋肾宁神胶囊高、中、低剂量组(剂量分别为9.96、4.98、2.49 g·kg-1·d-1);除空白对照... 相似文献
3.
Zhi-Qiang Wang Ning Wang Silvere van der Maarel Shen-Xing Murong Zhi-Ying Wu 《European journal of human genetics : EJHG》2011,19(1):64-69
Facioscapulohumeral muscular dystrophy (FSHD) is the third most common inherited muscular dystrophy with markedly clinical variability and complex genetic cause. Several reports pertaining to the Caucasian population have confirmed that there are 4qA and 4qB variants of the 4qter subtelomere, and FSHD is uniquely associated with the 4qA variant. However, few data relevant to the Chinese population have been published. In present paper, detailed clinical and genetic re-evaluations were performed in members of four special families who had been initially diagnosed as atypical or asymptomatic FSHD based only on the D4Z4 repeat length analysis. The FSHD-sized D4Z4 repeats in the probands from families 1, 2 and 3 were identified as 4qB variants. These patients were further confirmed as limb-girdle muscular dystrophy (LGMD2) or myotonic dystrophy (DM1) by molecular analyses. Specifically, we identified a 4qB variant on chromosome 10 in the healthy members of the fourth FSHD family with complex D4Z4 rearrangements of two exchanged repeat arrays. For the first time, we demonstrated in the Chinese population that D4Z4 contractions on the 4qB variant do not cause FSHD and 4qB variant on chromosome 10 might also represent intermediate structures in the transition from 4q to 10q. Furthermore, our results emphasize that D4Z4 repeat length analysis alone is not sufficient for the diagnosis of FSHD, especially when used as an exclusion criterion. This analysis should be accompanied by 4qA/4qB variant determination and integrated chromosome assignments, especially in patients with obscure and unclassified myopathies similar to atypical forms of FSHD. 相似文献
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INTRODUCTIONLipidstoragemyopathybelongstoinflammationofmusclecellscausedbyselfimmunity.(lipidstoragemyopathy,LSM).DomesticresearchesaboutitsevaluationwithMRIwereunavailable.Ourob-jectivewastoinvestigateMRIfindingsofLMIanditsvalueintheevaluationofLSM.MATERIALSANDMETHODSMaterials9LSMpatientsadmittedfromApril1998toApril2002werein-cludedinourstudy.Thesepatientsinclude5menand5womenaging4-36years(meanage:24.9years).Courseofdiseasevariedfrom9mont… 相似文献
6.
生长激素释放激素(growth hormone-releasing hormone,GHRH)又称生长激素释放因子(growth hormone-releasing factor,GRF),是由下丘脑分泌的一种肽类激素,具有促进垂体促生长素细胞合成和释放生长激素(growth hormone,GH)的作用,临床上可以用来治疗矮小症、HIV相关的脂肪营养不良、代谢综合征、艾滋病、创伤等疾病。然而GHRH应用到临床上的最大不足就是体内半衰期比较短(一般10~20min)。为了延长GHRH在体内的半衰期,减少频繁用药给患者带来的不适,须对GHRH进行修饰,以期达到半衰期显著延长,免疫原性有所降低。为此,本文主要综述了GHRH以及GHRH长效修饰的研究进展,尤其是PEG修饰GHRH的最新进展。 相似文献
7.
目的为了使护理本科生在较短的实习期内,以最快最好的方法,理解和掌握危重病学科(ICU)护理工作的重点和难点,提高护生对危重病患者的整体观察和抢救应急能力。方法在护理本科生临床带教中实验组应用阶段性目标教学法,根据其在ICU的实习大纲,将整个临床实习分为了解评估、熟悉练习、强化提高及考核评价4阶段进行。对照组是在外院实习但未应用阶段性目标教学法的学生。结果实验组护本生在理论和操作考核成绩优于对照组,学生的实习总体自我评价满意度明显高于对照组(p<0.05)。结论阶段性目标教学法能使护生学习目标更加明确,减少了学习的盲目性,充分发挥学生的主观能动性,由过去的被动学习转变为主动学习,在一定程度上培养了学生对危重病患者的整体观察和抢救应急能力;同时规范化管理,加强了带教老师的责任感,提高带教队伍的整体素质和教学质量。 相似文献
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9.
目的应用扫描电镜观察骨小梁微破裂形态及微骨痂的微观结构,探讨微骨痂的超微结构特征。方法取63周龄雌性SD大鼠第6腰椎椎体,沿冠状面切开,蒸馏水冲洗净骨髓腔后乙醇梯度脱水,表面喷金后应用扫描电镜观察,在600倍下观察骨小梁微破裂以及微骨痂的形态,在2000倍和10000倍下观察微骨痂的细微及超微结构。结果观察到微破裂长度约80μm,在骨微破裂一端靠近小梁边缘处,可见有微骨痂形成,微骨痂为一种疏松多孔的海绵状结构,其超微结构呈珊瑚礁形貌,由直径约0.2~0.5μm大小网状排列的骨小梁类似结构构成。结论在微骨痂修复微破裂过程中可能存在一种“超微小梁”结构,这种结构对于受损骨小梁承受应力以及修复均有利。 相似文献
10.
肝豆状核变性的症状前诊断及干预治疗的初步研究 总被引:2,自引:0,他引:2
应用短串联重复序列标记对40个肝豆状核变性家系进行单体型连锁分析。在先证者的81例无症状同胞中,检出11例症状前患者,对其中8例投用硫酸锌治疗,效果良好,在预防症状出现的同时,提高了血清铜蓝蛋白水平。强调症状前诊断及干预治疗的重要性。 相似文献