全文获取类型
收费全文 | 1260篇 |
免费 | 120篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 38篇 |
妇产科学 | 36篇 |
基础医学 | 114篇 |
口腔科学 | 53篇 |
临床医学 | 172篇 |
内科学 | 136篇 |
皮肤病学 | 34篇 |
神经病学 | 82篇 |
特种医学 | 56篇 |
外科学 | 93篇 |
综合类 | 115篇 |
预防医学 | 200篇 |
眼科学 | 8篇 |
药学 | 147篇 |
中国医学 | 43篇 |
肿瘤学 | 60篇 |
出版年
2024年 | 5篇 |
2023年 | 50篇 |
2022年 | 96篇 |
2021年 | 114篇 |
2020年 | 107篇 |
2019年 | 79篇 |
2018年 | 73篇 |
2017年 | 60篇 |
2016年 | 54篇 |
2015年 | 38篇 |
2014年 | 77篇 |
2013年 | 103篇 |
2012年 | 50篇 |
2011年 | 56篇 |
2010年 | 41篇 |
2009年 | 38篇 |
2008年 | 42篇 |
2007年 | 40篇 |
2006年 | 31篇 |
2005年 | 30篇 |
2004年 | 21篇 |
2003年 | 21篇 |
2002年 | 18篇 |
2001年 | 14篇 |
2000年 | 16篇 |
1999年 | 11篇 |
1998年 | 12篇 |
1997年 | 9篇 |
1996年 | 9篇 |
1995年 | 6篇 |
1994年 | 7篇 |
1993年 | 9篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 6篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 2篇 |
1985年 | 8篇 |
1984年 | 4篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1974年 | 2篇 |
排序方式: 共有1391条查询结果,搜索用时 46 毫秒
1.
A developmental validation was performed to demonstrate reliability, reproducibility and robustness of the ANDE System with the FlexPlex assay, including an integrated Expert System, across a number of laboratories and buccal sample variations. Previously, the related DNAscan™/ANDE 4C Rapid DNA System using the PowerPlex®16 assay and integrated Expert System Software received NDIS approval in March 2016. The enhanced ANDE instrument, referred to as ANDE 6C, and the accompanying 6-dye, 27-locus STR assay, referred to as FlexPlex, have been developed to be compatible with all widely used global loci, including the expanded set of the CODIS core 20 loci.Six forensic and research laboratories participated in the FlexPlex Rapid DNA developmental validation experiments, testing a total of 2045 swabs, including those obtained from 1387 unique individuals. The goal of this extensive and comprehensive validation was to thoroughly evaluate and document the ANDE System and its internal Expert System to reliably genotype reference buccal swab samples in a manner compliant with the FBI’s Quality Assurance Standards and the NDIS Operational Procedures.The ANDE System, including automated Expert System analysis, generated reproducible and concordant results for buccal swabs when testing various instruments at different laboratories by a number of different operators. When testing a number of non-human DNAs, including oral bacteria, the ANDE System and FlexPlex assay demonstrated limited cross-reactivity. Potential PCR inhibitors were evaluated as part of the validation and no inhibition was detected. Reproducible and concordant profiles were generated from buccal swab samples collected with a limit of detection appropriate for buccal swab collections from arrestees. The precision and resolution of the System met industry standards for detection of microvariants and single base resolution.The integrated Expert System appropriately demonstrated the ability to correctly pass or fail profiles for CODIS upload without human review. During this comprehensive developmental validation, the ANDE System successfully interpreted over 2000 samples tested with over 99.99% concordant alleles. The data package described herein led to the ANDE System with the FlexPlex assay receiving NDIS approval in June 2018. 相似文献
2.
目的本研究以护理结局分类(NOC)为基础,筛选符合慢性心力衰竭患者的相关护理结局,由此构建具有专科专病特点的慢性心力衰竭患者护理结局评价表。方法成立研究核心小组,应用文献回顾法、专家函询法确定护理结局分类指标,并进行统计学分析,最终建立慢性心力衰竭护理结局分类评价表。结果通过研究,确定慢性心力衰竭护理结局中包含4个领域、8个一级指标、68个二级指标。4个领域分别是生理健康、功能健康、健康知识和行为、心理社会健康。一级指标中包含心脏泵血功能、活动耐力、社会支持、抑郁水平等。二级指标中包含心脏指数、血压、呼吸困难、情绪波动大、步行距离、步行速度等68个指标。统计学分析中:第一、二轮函询专家的积极系数分别为90%、100%,专家权威系数为0.895,专家意见协调程度(P<0.05)。结论本研究成功建立慢性心力衰竭护理结局分类评价表,有助于临床护士用于评价护理措施的有效性,也使其成为一种标准化语言,便于应用到护理电子信息系统中进行绩效测算等。但是本研究不足之处是未能将该研究进行临床实证,未能进一步确认其有效性。 相似文献
3.
D M McSherry 《Statistics in medicine》1986,5(5):497-502
The independence Bayesian model has been used widely in computer programs designed to support clinical decision-making. A reasoning strategy has been developed to enable these programs to conduct clinically pertinent dialogue and explain their reasoning. It has been implemented in a program for the diagnosis of acute abdominal pain based on the Bayesian model of de Dombal et al. Several features of the dialogue design have been adopted from artificial intelligence research, including shared initiative and critiquing. The program adopts a flexible goal-driven strategy, attempting to confirm the clinician's diagnosis or rule out the likeliest alternative. Symptoms and signs are selected in order of their expected weights of evidence in favour of the hypothesized disease. 相似文献
4.
Shelley Allen Glenys Carlson Tamara Ownsworth Jenny Strong 《Australian Occupational Therapy Journal》2006,53(4):293-301
Aim: To present an evidence-based framework to improve the quality of occupational therapy expert opinions on work capacity for litigation, compensation and insurance purposes.
Methods: Grounded theory methodology was used to collect and analyse data from a sample of 31 participants, comprising 19 occupational therapists, 6 medical specialists and 6 lawyers. A focused semistructured interview was completed with each participant. In addition, 20 participants verified the key findings.
Results: The framework is contextualised within a medicolegal system requiring increasing expertise. The framework consists of (i) broad professional development strategies and principles, and (ii) specific strategies and principles for improving opinions through reporting and assessment practices.
Conclusions: The synthesis of the participants' recommendations provides systematic guidelines for improving occupational therapy expert opinion on work capacity. 相似文献
Methods: Grounded theory methodology was used to collect and analyse data from a sample of 31 participants, comprising 19 occupational therapists, 6 medical specialists and 6 lawyers. A focused semistructured interview was completed with each participant. In addition, 20 participants verified the key findings.
Results: The framework is contextualised within a medicolegal system requiring increasing expertise. The framework consists of (i) broad professional development strategies and principles, and (ii) specific strategies and principles for improving opinions through reporting and assessment practices.
Conclusions: The synthesis of the participants' recommendations provides systematic guidelines for improving occupational therapy expert opinion on work capacity. 相似文献
5.
The relationship between quality of life (QOL) assessments and decision making, in relation to the delivery of health services, is subjected to critical appraisal. Three levels of decision making in the health care system are taken into account in the analysis. Criticisms of opinion polling provide the basis for the appraisal. Examples of criticisms considered are: Might the use of QOL information be manipulative? Could the interviews or questionnaires used to obtain QOL data influence personal opinions? Are the methods used sometimes defective and/or superficial? Will QOL information always be used in decision making in ways that are ascertainable and justifiable? It is concluded that the time has come for the main focus of critical appraisal in QOL research to shift, from an emphasis on evaluation of the quality of methods used for assessments of QOL, toward an emphasis on the practical usefulness of QOL data. 相似文献
6.
A program called “An Epidemiological Approach to Computerized Medical Diagnosis” (AEDMI) is presented. Using an interactive questionnaire, physician-patient interviews are conducted and a summary of the relevant clinical data is provided. Standard items, obained on a multi-centre basis, form a large-scale data base. Simultaneously, the reasoning of clinical experts in each real case is analyzed to obtain a knowledge-rules data base. The methodology of the program combines Bayesian systems, expert systems, and other new lines of researcg such as neural networks or case-based reasoning. The general concepts of clinical decision making aid systems are reviewed. This publication is aimed at obtaining international cooperation. 相似文献
7.
《Journal of microbiology, immunology, and infection》2019,52(6):841-850
Clostridium difficile infection (CDI) remains a major public health issue, and fecal microbiota transplantation (FMT) has become one of the standard therapies for recurrent or refractory CDI. When compared to medical therapies, such as metronidazole or vancomycin, FMT has a high rate of treatment response with acceptable safety and efficiency. Following promulgation of the amendments in September 2018 in Taiwan, FMT has been indicated for recurrent or refractory CDI. The Taiwan Microbiota Consortium contributed to the Taiwan FMT Expert Consensus, which established basic norms and stipulated essential principles, including the indications for transplantation, eligible locations and personnel, donor screening policies, fecal sample handling, and post-FMT follow-up. However, establishing an eligible FMT team in a qualified hospital remains a clinical challenge, and the requirement for facilities and well-screened donors impedes the implementation of FMT. In this review, we aim to provide domestic FMT teams with explicit instructions to facilitate realization and increase the practice of FMT. Based on the Taiwan FMT Expert Consensus and current regulations, we performed a literature review and integrated the experiences of Taiwanese multidisciplinary experts into this article. The content intends to offer clinicians up-to-date evidence and highlight the essential points of FMT. 相似文献
8.
Identification of micro-emboli in the cerebral circulation using transcranial Doppler ultrasound provides valuable clinical
information, but, currently, embolic signal detection and analysis are significantly limited because they mainly rely on costly
off-line analysis by human experts. In this study, a reliable, high-resolution, real-time automated system for the detection
and archiving of embolic signals was designed and implemented using expert system theory and modern DSP technology. Preliminary
tests were conducted to evaluate the functions and the performance of the system using data from ten carotid endarterectomy
patients and two normal volunteers. Using the widely accepted 7 dB threshold for human reliability and a human expert, majority-decision
gold standard, the real-time system reached sensitivity and specificity of 93.6% and 99.3%, respectively, which were close
to the results obtained by three human experts under ideal laboratory conditions (90.1% and 99.8%, 98.4% and 99.9%, 98.9 and
99.9%). The new system has the potential to be used either as a bedside monitoring and signal acquisition device, or as a
laboratory investigation tool. 相似文献
9.
10.
不同时期在押罪犯司法精神病学鉴定案例的对比分析 总被引:4,自引:0,他引:4
冯斌 《中国行为医学科学》2001,10(5):450-451
目的 探讨近年来在押犯罪司法精神病学鉴定的特点和发展趋势。方法 对1994年后经该院鉴定的87例与1993年前鉴定的33例在押罪犯案例进行对比分析。结果 1994年后组在押罪犯鉴定的案例明显增加(P<0.01)。服刑能力的鉴定,1994年后组较多(P<0.01),服教能力的鉴定,1993年前组较多(P<0.05)。1994年后组经济类案件有上升趋势(P<0.05),诊断为精神分裂症的有明显下降(P<0.01),诊断为拘禁性精神障碍的有明显上升(P<0.05)。结论 在押罪犯司法精神病学鉴定已成为司法精神病学鉴定的重要组成部分,对其法定能力的评定需进一步入研究。 相似文献