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1.
建立了毛细管气相色谱法测定兰索拉唑中甲醇、丙酮、乙腈、氯仿的残留量.采用RTX-50毛细管柱,程序升温.各溶剂检测限分别为18、50.4、1.46和0.4ng,平均回收率分别为102.3%、100.4%、101.8%和1013%. 相似文献
2.
Dr. Malcolm Robinson MD Donald R. Campbell MD Stephen Sontag MD Seymour M. Sabesin MD 《Digestive diseases and sciences》1995,40(3):590-597
Fifty-four patients with endoscopically documented therapy-resistant erosive reflux esophagitis were treated with lansoprazole, a new proton pump inhibitor, for up to 12 weeks. Prior to entry, all had remained unhealed after treatment with at least two histamine2-receptor antagonists, at therapeutic doses or higher, for at least 12 weeks. Patients were randomized to receive either 30 or 60 mg lansoprazole once daily. Endoscopy was performed and symptoms assessed at weeks 2, 4, 6, 8, and 12. Fifty-nine percent of the 50 evaluable patients were healed (ie, no evidence of erosions) after only two weeks of lansoprazole. Cumulative endoscopic healing rates were 82% and 92% by week 4 and week 8, respectively, and the two doses were equally effective in healing. The 30- and 60-mg doses effected a decrease in the overall symptom score from 5.30 and 4.85 to 2.35 and 1.67, respectively, by the final treatment visit (P=0.001). No clinically significant adverse events or changes in laboratory parameters were observed, and no patients withdrew prematurely from the study. This study demonstrates that lansoprazole therapy is highly effective in healing erosive reflux esophagitis resistant to therapy with histamine H2-receptor antagonists.Supported by a grant from TAP Pharmaceuticals Inc., Deerfield, Illinois. 相似文献
3.
Effect of lansoprazole on DNA integrity of human spermatozoa and activity of seminal creatine kinase
Although lansoprazole (brand name Prevacid) is a commonly used dug to manage various acid-related gastrointestinal diseases, little is known about its effects on human semen quality and sperm parameters. Here, we aimed to investigate the effect of lansoprazole on DNA integrity of human spermatozoa and activity of seminal creatine kinase. DNA integrity of human spermatozoa was assessed by the Apo-Direct™ kit followed by flow cytometry. The activity of creatine kinase was measured by kinetic spectrophotometric method using commercially available kits following the International Federation of Clinical Chemistry recommendations. Lansoprazole at 3 µg/ml, after 1-hr incubation period, did not show any significant increase in fluorescein isothiocyanate fluorescence (p > .05) and hence on the content of DNA breaks of human spermatozoa. In addition, there was no significant change (p = .8113) in the activity of seminal creatine kinase by the effect of lansoprazole. In conclusion, lansoprazole at 3 µg/ml did not alter DNA integrity of human spermatozoa or activity of seminal creatine kinase after 1-hr incubation period. 相似文献
4.
Adachi K Fujishiro H Mihara T Komazawa Y Kinoshita Y 《Journal of gastroenterology and hepatology》2003,18(2):168-171
BACKGROUND AND AIM: The sensitivity of the urea breath test (UBT) has been reported to be influenced by the administration of omeprazole, lansoprazole and ranitidine. However, it is unclear whether other H2 receptor antagonists (H2RA), except ranitidine, and rebamipide, a mucosal protective agent, affect UBT sensitivity. The aim of this study is to clarify the effects of lansoprazole, famotidine, roxatidine and rebamipide administration on UBT sensitivity. METHODS: Subjects comprised 30 volunteers with Helicobacter pylori infection. All subjects were examined by the 13C-UBT on four occasions: (i) without medication (control); (ii) after the administration of 30 mg lansoprazole (u.i.d) for 14 days; (iii) after the administration of 100 mg rebamipide (t.i.d) for 14 days; and (iv) after the administration of 20 mg famotidine or 75 mg roxatidine (b.i.d) for 14 days. In the H2RA study, individuals were randomized into two groups of 15 subjects and were administered either famotidine or roxatidine. RESULTS: Five of the 30 cases administered lansoprazole and one of the 15 cases given roxatidine gave a false-negative UBT result. No negative UBT results were observed in patients administered famotidine or rebamipide. CONCLUSION: Patients showing negative UBT results during the administration of proton pump inhibitors and H2RA should be re-examined after the cessation of these drugs to confirm the true negativity of H. pylori infection. 相似文献
5.
目的:建立 RP-HPLC 法测定人血浆中兰索拉唑浓度。方法:1 mL 血浆样品以奥美拉唑为内标,加入0.5 mL Na_2HPO_4溶液(0.5 mol·L~(-1),pH 9.05)碱化,用5 mL 乙醚-二氯甲烷(7:3,v/v)混合液振荡萃取,分取有机相空气流下吹干。残渣用200μL甲醇-0.1 mol·L~(-1)碳酸钠(50:50,v/v)混合液溶解,40 μL进样。采用 NUCLEOSIL C_(18)分析柱(250 mm×4.6 mm,5μm),以0.025 mol·L~(-1)磷酸二氢钠-乙腈(60:40,v/v)为流动相,流速为1 mL·min~(-1),柱温为30℃,于285 nm 波长下检测。结果:兰索拉唑在20~2400μg·L~(-1)范围内线性关系良好(r=0.9996),最低检测浓度为20μg·L~(-1)。血浆中低、中、高3种浓度的萃取回收率(n=5)分别为69.9%,64.0%,58.8%;RSD(n=5)分别为7.94%,5.33%,5.39%;方法回收率(n=5)分别为98.6%,106.3%,101.9%;日内和日间精密度均小于10%。结论:该法操作简单,灵敏,准确,重现性好,适用于该药的临床药代动力学研究。 相似文献
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8.
目的采用高效液相色谱法建立注射用兰索拉唑有关物质检查及其含量测定方法。方法Diamonsil-C18柱(4.6 mm×200 mm,5μm),以甲醇-水-三乙胺-磷酸(640∶360∶5∶1.5,pH为7.3)为流动相,检测波长为284 nm。结果制剂中辅料对主药测定无干扰,兰索拉唑与有关物质完全分离。在10.0~400.0 mg·L-1内峰面积与浓度呈良好的线性关系。精密度(RSD=0.13%)良好。平均回收率为99.6%。结论本方法简便,迅速,准确,专属性强。 相似文献
9.
兰索拉唑口服治疗消化性溃疡急性大出血 总被引:5,自引:1,他引:4
目的:观察兰索拉唑口服治疗消化性溃疡急性大出血的疗效。方法:30例消化性溃疡急性大出血病人(男性24例,女性6例,年龄48±s16a)予兰索拉唑30mg,po,qd×(10~14d),并酌情输液、输血。结果:兰索拉唑30例(100%)止血成功,住院天数为14.1±2.1d;输血量为0。未见药物不良反应。结论:兰索拉唑口服对消化性溃疡急性大出血有良好疗效。 相似文献
10.
兰索拉唑对消化溃疡的疗效和药物动力学及生物利用度 总被引:3,自引:0,他引:3
目的:观察兰索拉唑对消化性溃疡的疗效和患者体内药物动力学及生物利用度。方法:31例消化性溃疡患者随机分成两组,分别PO两组兰索拉唑制剂30mg.qd,连续服用1mo后观察儿,并用HPLC法测定单剂量PO后的血药浓度,模拟房室模型度计算药物动力学参数及利用度。结果:国产和进口制剂用药后5d内腹痛消失的病人均约占70%,总有效率为100%,组间无明显差别(P〉0.05);单剂量PO后的经浓度时间曲线均 相似文献