吴茱萸化学成分和药理作用及质量标志物(Q-marker)的预测分析

吴茱萸是我国常用的大宗中药材,资源丰富且分布较广,具有广阔的开发利用前景。吴茱萸中化学成分类型丰富,包括生物碱、苦味素、挥发油、黄酮等类成分,传统认为生物碱和苦味素为其主要药效成分。对其化学成分、药理作用综述的基础上,根据中药质量标志物(Q-marker)理论,从生源途径、化学成分与传统功效、传统药性、新的临床用途、毒性、可测成分、入血成分及不同配伍环境几方面对吴茱萸Q-marker成分进行预测分析,为明确吴茱萸Q-marker和制定科学的质量标准提供基础。     

Compartment syndrome. Exclusively the result of increased pressure in the muscular compartment?

Summary The compartment syndrome (cs) is characterized by an increased tissue pressure in a limited space. Pathophysiologically, it is a multifactorial disease that is potentially induced by an initial trauma and develops according to the existence of cofactors. Cofactors are, for instance, the circulation of the patient and the initial treatment of the impending cs. In particular, the microcirculation is altered with endothelial destruction, development of a capillary leak, protein loss from intravasal space and the development of an interstitial and intracellular third space. An impaired drainage of the lymphatic and venous system causes a venous infarction. An arterial infarction results if the tissue pressure exceeds the arteriolar pressure. An accompanying ischemia reperfusion mechanism increases the trauma load. In disadvantageous cases, the patients are in danger of developing a multi-organ deficiency syndrome (MODS) by an uncontrolled inflammatory reaction, by intravasal volume loss and by a myonephropathic systemic reaction. Clinically, the patients suffer a disproportionate amount of pain, followed by neurological signs. Especially in noncompliant patients, tissue pressure measurement is useful. Resuscitation of the circulation as well as splitting of casts is important. In case of a manifest cs, dermatofasciotomy has to be performed as an emergency operation. Even if cs is diagnosed early and fasciotomy is carried out early, the development of sequellae cannot be avoided in every single case.      

Without Parental Consent: Conducting Research With Homeless Adolescents

ISSUES AND PURPOSE. To identify the ethical and legal implications of conducting research with homeless adolescents and to discuss guidelines for conducting research without parental consent.
CONCLUSIONS. Ethical principles of capacity, risk, postponement, and truthful disclosure within the context of the rights of minors to consent to healthcare treatment form the basis of the argument for allowing adolescents to consent to participate in research without parental consent when there is minimal risk or when such consent could place them at increased risk for harm.
PRACTICE IMPLICATIONS. Adolescents who are the target population for clinical research or who are intended recipients of nursing care should be involved in setting priorities, purposes, and protocols. Parents and other adults from their communities should be included in developing strategies to protect their confidentiality and privacy while helping them achieve autonomy in making informed health-related decisions.     

中医辨证在航天医学中应用的可能性分析

为探讨中医在载人航天中的应用,用中医学辨证论治方法,分析了航天环境(包括微重力、辐射.狭小隔离环境、昼夜节律变化等)对机体的生理影响,认为在航天初期是实证,辨证为:经气厥道,升降失常,治则为升清降浊止呕,活血行气开窍;航天时间较长期时,由于航天环境长期的综合作用,损伤人体正气,使人体呈现虚实夹杂的症状,辨证为肝肾阴虚合并血瘀气滞,治则:滋阴补肾柔肝,健脾益气活血.     

The Development and Teaching of the Ethical Principles and Guidelines for Family Scientists*

This article describes the development of the Ethical Principles and Guidelines for Family Scientists that the National Council on Family Relations Board of Directors unanimously approved. Furthermore, it discusses the importance of ethics education for family professionals and provides suggestions for educators. Finally, the ethical principles and guidelines are delineated. We argue that the development of a scholarship on ethics education is important for current and future family scientists.     

Surveillance of resistance in bacteria causing community-acquired respiratory tract infections

Bacterial resistance to antibiotics in community-acquired respiratory tract infections is a serious problem and is increasing in prevalence world-wide at an alarming rate. Streptococcus pneumoniae , one of the main organisms implicated in respiratory tract infections, has developed multiple resistance mechanisms to combat the effects of most commonly used classes of antibiotics, particularly the β -lactams (penicillin, aminopenicillins and cephalosporins) and macrolides. Furthermore, multidrug-resistant strains of S. pneumoniae have spread to all regions of the world, often via resistant genetic clones. A similar spread of resistance has been reported for other major respiratory tract pathogens, including Haemophilus influenzae , Moraxella catarrhalis and Streptococcus pyogenes . To develop and support resistance control strategies it is imperative to obtain accurate data on the prevalence, geographic distribution and antibiotic susceptibility of respiratory tract pathogens and how this relates to antibiotic prescribing patterns. In recent years, significant progress has been made in developing longitudinal national and international surveillance programs to monitor antibiotic resistance, such that the prevalence of resistance and underlying trends over time are now well documented for most parts of Europe, and many parts of Asia and the Americas. However, resistance surveillance data from parts of the developing world (regions of Central America, Africa, Asia and Central/Eastern Europe) remain poor. The quantity and quality of surveillance data is very heterogeneous; thus there is a clear need to standardize or validate the data collection, analysis and interpretative criteria used across studies. If disseminated effectively these data can be used to guide empiric antibiotic therapy, and to support—and monitor the impact of—interventions on antibiotic resistance.     

《内经》论瘀血的治法及其影响

将《内经》中有关瘀血治不的内容概括为：①攻下逐瘀法,用于治疗瘀血邪热在内,且病情较重之证;②温经化瘀法,代表方为四乌骨一芦茹丸,用于治疗精血枯竭、月经闭止之证;③活血利水法,代表方为鸡失醴,用于治疗瘀血水停之证;④散寒化瘀法,代表方为熨方,本法适用于寒邪外袭、瘀血内停之证。《内经》有关瘀血治法的内容对后世中医瘀血之治疗具有重要的指导意义。     

中医内科急症概论(下)

内科急症的辨证要点在于辨外感与内伤、辨脏腑病位、辨病理因素、辨标本主次、辨病势传变与顺逆、辨证与辨病。急症的治疗当以急则治标、综合救疗、证病合治、祛邪扶正、防传杜变、严密监护为基本原则。     

简论激励在学校管理中的运用

激励在学校管理中具有十分重要的意义。目标激励、物质激励、精神激励、榜样激励是学校管理中经常运用的激励方法。适时、适度 ,公平、公正 ,物质与精神并重 ,是学校管理中必须坚持的科学的激励原则     

骨折与中医食疗

骨折病人食疗的基本原则是整体观念和辨证施食。本文以骨折的三期分治为原则,再根据不同的病因,病程的久暂以及病人的体质等情况分别立法施食,以加快骨折愈合及功能恢复。食疗的组方原则为理气活血,培元益气,化痰祛湿,利水消瘀。