全文获取类型
收费全文 | 12384篇 |
免费 | 862篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 87篇 |
儿科学 | 401篇 |
妇产科学 | 364篇 |
基础医学 | 1473篇 |
口腔科学 | 137篇 |
临床医学 | 2211篇 |
内科学 | 1960篇 |
皮肤病学 | 162篇 |
神经病学 | 1182篇 |
特种医学 | 270篇 |
外科学 | 1188篇 |
综合类 | 219篇 |
一般理论 | 24篇 |
预防医学 | 1461篇 |
眼科学 | 282篇 |
药学 | 826篇 |
2篇 | |
中国医学 | 7篇 |
肿瘤学 | 1011篇 |
出版年
2023年 | 53篇 |
2022年 | 42篇 |
2021年 | 178篇 |
2020年 | 138篇 |
2019年 | 222篇 |
2018年 | 260篇 |
2017年 | 206篇 |
2016年 | 201篇 |
2015年 | 238篇 |
2014年 | 325篇 |
2013年 | 581篇 |
2012年 | 781篇 |
2011年 | 896篇 |
2010年 | 476篇 |
2009年 | 460篇 |
2008年 | 807篇 |
2007年 | 815篇 |
2006年 | 881篇 |
2005年 | 863篇 |
2004年 | 913篇 |
2003年 | 856篇 |
2002年 | 766篇 |
2001年 | 173篇 |
2000年 | 118篇 |
1999年 | 134篇 |
1998年 | 134篇 |
1997年 | 102篇 |
1996年 | 76篇 |
1995年 | 104篇 |
1994年 | 73篇 |
1993年 | 78篇 |
1992年 | 103篇 |
1991年 | 73篇 |
1990年 | 78篇 |
1989年 | 67篇 |
1988年 | 62篇 |
1987年 | 65篇 |
1986年 | 78篇 |
1985年 | 61篇 |
1984年 | 62篇 |
1983年 | 66篇 |
1982年 | 52篇 |
1981年 | 61篇 |
1980年 | 67篇 |
1979年 | 39篇 |
1978年 | 41篇 |
1977年 | 34篇 |
1976年 | 30篇 |
1975年 | 30篇 |
1973年 | 33篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
Mary Lynn McPherson Kathryn A. Walker Mellar P. Davis Eduardo Bruera Akhila Reddy Judith Paice Kasey Malotte Dawn Kashelle Lockman Charles Wellman Shelley Salpeter Nina M. Bemben James B. Ray Bernard J. Lapointe Roger Chou 《Journal of pain and symptom management》2019,57(3):635-645.e4
Methadone has several unique characteristics that make it an attractive option for pain relief in serious illness, but the safety of methadone has been called into question after reports of a disproportionate increase in opioid-induced deaths in recent years. The American Pain Society, College on Problems of Drug Dependence, and the Heart Rhythm Society collaborated to issue guidelines on best practices to maximize methadone safety and efficacy, but guidelines for the end-of-life scenario have not yet been developed. A panel of 15 interprofessional hospice and palliative care experts from the U.S. and Canada convened in February 2015 to evaluate the American Pain Society methadone recommendations for applicability in the hospice and palliative care setting. The goal was to develop guidelines for safe and effective management of methadone therapy in hospice and palliative care. This article represents the consensus opinion of the hospice and palliative care experts for methadone use at end of life, including guidance on appropriate candidates for methadone, detail in dosing, titration, and monitoring of patients' response to methadone therapy. 相似文献
3.
C. S. D. Roxburgh P. Strombom P. Lynn A. Cercek M. Gonen J. J. Smith L. K. F. Temple G. M. Nash J. G. Guillem P. B. Paty J. Shia E. Vakiani R. Yaeger Z. K. Stadler N. H. Segal D. Reidy A. Varghese A. J. Wu C. H. Crane M. J. Gollub L. B. Saltz J. Garcia‐Aguilar M. R. Weiser 《Colorectal disease》2019,21(10):1140-1150
4.
5.
6.
7.
Kadakia Kunal C. Kidwell Kelley M. Barton Debra L. Schott Anne F. Hayes Daniel F. Griggs Jennifer J. Henry N. Lynn 《Breast cancer research and treatment》2019,175(1):181-189
Breast Cancer Research and Treatment - Extending adjuvant endocrine therapy (ET) beyond 5 years has been shown to improve outcomes in breast cancer; however, limited data are available... 相似文献
8.
Laura L. Pitts Lynn Rogers Xue Wang Mariana M. Bahia Leora R. Cherney 《Topics in stroke rehabilitation》2020,27(4):241-250
ABSTRACT
Background
Post-stroke dysphagia is characterized by reduced corticolingual excitability and lingual pressure; however, it remains unknown if transcranial magnetic stimulation (TMS) directly facilitates lingual pressure generation. 相似文献9.
Peffault de Latour Rgis Huynh Lynn Ivanova Jasmina I. Totev Todor Bilginsoy Mehmet Antin Joseph Roy Anuja Duh Mei Sheng 《Annals of hematology》2020,99(4):743-752
Annals of Hematology - This study assessed treatment patterns and healthcare resource utilization (HRU) of patients with severe aplastic anemia (SAA) with insufficient response to immunosuppressive... 相似文献
10.
A. B. Dulbecco D. E. Moriconi S. Lynn A. McCarthy M. P. Jurez J. R. Girotti G. M. Caldern‐Fernndez 《Insect molecular biology》2020,29(5):431-443
Insect cuticle hydrocarbons are involved primarily in waterproofing the cuticle, but also participate in chemical communication and regulate the penetration of insecticides and microorganisms. The last step in insect hydrocarbon biosynthesis is carried out by an insect‐specific cytochrome P450 of the 4G subfamily (CYP4G). Two genes (CYP4G106 and CYP4G107) have been reported in the triatomines Rhodnius prolixus and Triatoma infestans. In this work, their molecular and functional characterization is carried out in R. prolixus, and their relevance to insect survival is assessed. Both genes are expressed almost exclusively in the integument and have an expression pattern dependent on the developmental stage and feeding status. CYP4G106 silencing diminished significantly the straight‐chain hydrocarbon production while a significant reduction – mostly of methyl‐branched chain hydrocarbons – was observed after CYP4G107 silencing. Molecular docking analyses using different aldehydes as hydrocarbon precursors predicted a better fit of straight‐chain aldehydes with CYP4G106 and methyl‐branched aldehydes with CYP4G107. Survival bioassays exposing the silenced insects to desiccation stress showed that CYP4G107 is determinant for the waterproofing properties of the R. prolixus cuticle. This is the first report on the in vivo specificity of two CYP4Gs to make mostly straight or methyl‐branched hydrocarbons, and also on their differential contribution to insect desiccation. 相似文献