吴茱萸化学成分和药理作用及质量标志物(Q-marker)的预测分析

吴茱萸是我国常用的大宗中药材,资源丰富且分布较广,具有广阔的开发利用前景。吴茱萸中化学成分类型丰富,包括生物碱、苦味素、挥发油、黄酮等类成分,传统认为生物碱和苦味素为其主要药效成分。对其化学成分、药理作用综述的基础上,根据中药质量标志物(Q-marker)理论,从生源途径、化学成分与传统功效、传统药性、新的临床用途、毒性、可测成分、入血成分及不同配伍环境几方面对吴茱萸Q-marker成分进行预测分析,为明确吴茱萸Q-marker和制定科学的质量标准提供基础。

Chemical components and pharmacological action for Euodiae Fructus and predictive analysis on its Q-marker

Euodiae Fructus is one of the most commonly used traditional Chinese medicinal materials with rich resource and wide distribution. It has broad prospects for development and utilization. The chemical constituents of Euodiae Fructus are abundant, including alkaloids, bitter principles, volatile oils, flavonoids and so on. Traditionally, the alkaloids and bitter principles are considered as its main pharmacodynamic components. Based on the review of its chemical composition and pharmacological action of herbal medicine, according to the theory of quality marker, the quality maker of Euodiae Fructus were predicted from the aspects of source, chemical composition and traditional efficacy, traditional medicinal properties, new clinical uses, and toxicity, measurable ingredients, blood-entering ingredients and different compatible environments, which provide a basis for defining quality markers and formulating scientific quality standards of Euodiae Fructus.