全文获取类型
收费全文 | 263968篇 |
免费 | 23274篇 |
国内免费 | 11867篇 |
专业分类
耳鼻咽喉 | 2670篇 |
儿科学 | 5739篇 |
妇产科学 | 3082篇 |
基础医学 | 45736篇 |
口腔科学 | 7022篇 |
临床医学 | 20813篇 |
内科学 | 40826篇 |
皮肤病学 | 5685篇 |
神经病学 | 18224篇 |
特种医学 | 5348篇 |
外国民族医学 | 138篇 |
外科学 | 20887篇 |
综合类 | 41097篇 |
现状与发展 | 69篇 |
预防医学 | 9553篇 |
眼科学 | 4761篇 |
药学 | 25768篇 |
38篇 | |
中国医学 | 8025篇 |
肿瘤学 | 33628篇 |
出版年
2024年 | 186篇 |
2023年 | 3317篇 |
2022年 | 4589篇 |
2021年 | 8708篇 |
2020年 | 8103篇 |
2019年 | 7829篇 |
2018年 | 8118篇 |
2017年 | 8566篇 |
2016年 | 9242篇 |
2015年 | 10511篇 |
2014年 | 15946篇 |
2013年 | 17954篇 |
2012年 | 15766篇 |
2011年 | 17694篇 |
2010年 | 14460篇 |
2009年 | 14078篇 |
2008年 | 14773篇 |
2007年 | 14655篇 |
2006年 | 13258篇 |
2005年 | 12222篇 |
2004年 | 10520篇 |
2003年 | 9097篇 |
2002年 | 7309篇 |
2001年 | 6224篇 |
2000年 | 5265篇 |
1999年 | 4517篇 |
1998年 | 3769篇 |
1997年 | 3517篇 |
1996年 | 2979篇 |
1995年 | 3000篇 |
1994年 | 2694篇 |
1993年 | 2271篇 |
1992年 | 1843篇 |
1991年 | 1725篇 |
1990年 | 1364篇 |
1989年 | 1234篇 |
1988年 | 1157篇 |
1987年 | 969篇 |
1986年 | 881篇 |
1985年 | 1428篇 |
1984年 | 1373篇 |
1983年 | 931篇 |
1982年 | 1022篇 |
1981年 | 875篇 |
1980年 | 774篇 |
1979年 | 585篇 |
1978年 | 454篇 |
1977年 | 340篇 |
1976年 | 353篇 |
1975年 | 216篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
《Saudi Pharmaceutical Journal》2022,30(6):669-678
BackgroundIschemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat.MethodsRat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed.ResultsPre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators.ConclusionOur result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction. 相似文献
2.
3.
4.
5.
6.
7.
8.
《European journal of surgical oncology》2022,48(5):1062-1067
BackgroundSurgical resection is recommended for patients with resectable acinar cell carcinoma (ACC). The aim of this study was to investigate the clinical characteristics and surgical outcomes of resectable ACC in comparison to pancreatic ductal adenocarcinoma (PDAC).MethodA retrospective analysis was performed on all patients who consecutively underwent radical resection with pathologically confirmed ACC and PDAC from December 2011 to December 2018. Clinicopathologic characteristics and follow-up information were analyzed. A 1:3 propensity score matching (PSM) method was used to minimize the bias between ACC and PDAC.ResultsA total of 26 patients with ACC and 1351 with PDAC were included. Compared to PDAC, ACC tended to be larger (4.5 vs. 3.0 cm; p < 0.001) and more frequently located in the pancreatic body/tail (61.5% vs. 36.6%, p = 0.009), with lower total bilirubin levels, lower neutrophil lymphocyte ratio (NLR) levels and lower carbohydrate antigen 19-9 (CA19-9) levels and carcinoembryonic antigen (CEA) levels. There was no difference in postoperative morbidities in patients with ACC and PDAC. The median OS and RFS were longer in ACC when compared to PDAC (OS: 43.5 mo vs. 19.0 mo, p = 0.004; RFS: 24.5 mo vs. 11.6 mo, p = 0.023). After the 1:3 PSM, ACC remained to be a better histological type for OS (p = 0.024), but had comparable RFS with PDAC (p = 0.164).ConclusionPatients with ACC after radical resection had better OS than that with PDAC. However, ACC is also an aggressive tumor with a similar trend of RFS with PDAC after the matching, necessitating the multidisciplinary treatment for resectable ACC disease. 相似文献
9.
Wassan Nori 《World Journal of Clinical Cases》2022,10(30):11210-11213
Numerous risk variables, including age, medical co-morbidities, and deranged inflammatory response, lead to higher mortality in a senior population with coronavirus disease 2019. C-reactive protein (CRP), an acute phase inflammatory protein secreted by the liver, was tested in the elderly, showing a diagnostic and prognostic role. However, recent research has shed light on new applications for CRP in geriatrics. It was used as a follow-up marker and as a therapeutic target. Early and accurate identification of patients' risks may mitigate the devastation of the invading virus in older cases and permit the implementation of a quick treatment plan for those most likely to deteriorate. 相似文献
10.