Cardioprotective effects of sinomenine in myocardial ischemia/reperfusion injury in a rat model期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Cardioprotective effects of sinomenine in myocardial ischemia/reperfusion injury in a rat model

Institution:	1. Department of Heart Center, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China;2. Department of Emergency, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China;3. Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao City, Shandong Province 266000, China

Abstract:	BackgroundIschemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat.MethodsRat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed.ResultsPre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators.ConclusionOur result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction.

Keywords:	Sinomenine Ischemia reperfusion Arrhythmias Antioxidant Plasmin system I/R"} {"#name":"keyword" "$":{"id":"k0035"} "$$":[{"#name":"text" "_":"Ischemia reperfusion SM"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"Sinomenine NC"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"Normal control VEB"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"Ventricular ectopic beat CK-MB"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"Creatine kinase MB CK"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"Creatine kinase Tnl"} {"#name":"keyword" "$":{"id":"k0095"} "$$":[{"#name":"text" "_":"Troponin I TF"} {"#name":"keyword" "$":{"id":"k0105"} "$$":[{"#name":"text" "_":"Tissue factor TXB2"} {"#name":"keyword" "$":{"id":"k0115"} "$$":[{"#name":"text" "_":"Thromboxane B2 PAI-1"} {"#name":"keyword" "$":{"id":"k0125"} "$$":[{"#name":"text" "_":"Plasminogen activator inhibitor 1 Fbg"} {"#name":"keyword" "$":{"id":"k0135"} "$$":[{"#name":"text" "_":"Plasma fibrinogen ATP"} {"#name":"keyword" "$":{"id":"k0145"} "$$":[{"#name":"text" "_":"Adenosine triphosphate MII"} {"#name":"keyword" "$":{"id":"k0155"} "$$":[{"#name":"text" "_":"Myocardial ischemic injury IHD"} {"#name":"keyword" "$":{"id":"k0165"} "$$":[{"#name":"text" "_":"Ischemic heart disease LAD"} {"#name":"keyword" "$":{"id":"k0175"} "$$":[{"#name":"text" "_":"Left anterior descending coronary artery K-H"} {"#name":"keyword" "$":{"id":"k0185"} "$$":[{"#name":"text" "_":"Krebs-Henseleit PVC"} {"#name":"keyword" "$":{"id":"k0195"} "$$":[{"#name":"text" "_":"Premature ventricular contraction MDA"} {"#name":"keyword" "$":{"id":"k0205"} "$$":[{"#name":"text" "_":"Malonaldehyde GPx"} {"#name":"keyword" "$":{"id":"k0215"} "$$":[{"#name":"text" "_":"Glutathione peroxidase CAT"} {"#name":"keyword" "$":{"id":"k0225"} "$$":[{"#name":"text" "_":"Catalase SOD"} {"#name":"keyword" "$":{"id":"k0235"} "$$":[{"#name":"text" "_":"Superoxide dismutase AST"} {"#name":"keyword" "$":{"id":"k0245"} "$$":[{"#name":"text" "_":"Aspartate aminotransferase LDH"} {"#name":"keyword" "$":{"id":"k0255"} "$$":[{"#name":"text" "_":"Lactate dehydrogenase IL-1β"} {"#name":"keyword" "$":{"id":"k0265"} "$$":[{"#name":"text" "_":"Interleukin-1β MCP-1"} {"#name":"keyword" "$":{"id":"k0275"} "$$":[{"#name":"text" "_":"Monocyte chemoattractant protein-1 hs-CRP"} {"#name":"keyword" "$":{"id":"k0285"} "$$":[{"#name":"text" "_":"C-reactive protein IL-6"} {"#name":"keyword" "$":{"id":"k0295"} "$$":[{"#name":"text" "_":"Interleukin-6 TNF-α"} {"#name":"keyword" "$":{"id":"k0305"} "$$":[{"#name":"text" "_":"Tumor necrosis factor-α SD"} {"#name":"keyword" "$":{"id":"k0315"} "$$":[{"#name":"text" "_":"Standard deviation WHO"} {"#name":"keyword" "$":{"id":"k0325"} "$$":[{"#name":"text" "_":"World Health Organization PCI"} {"#name":"keyword" "$":{"id":"k0335"} "$$":[{"#name":"text" "_":"Percutaneous coronary intervention
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