洞形与抗剪切能力的关系

目的：研究盒型洞两侧的余留牙体组织与底面不同移行方式时抗剪切能力的关系。方法：将新鲜离体牙的一部分制备成符合要求的两组试件。第一组试件的两侧壁轴向加载，第二组试件两侧壁侧向加载，分别记录两侧不同形状侧壁的抗剪切力值。结果：轴向加载，不同形状的侧壁抗剪切力无显著性差异（P〉0.5）；侧向加载，不同形状的侧壁抗剪切力有高度显著性差异（P〈0．00001）。结论：两侧壁受到轴向负载时，其抗剪切能力与洞形无关，受侧向负载时，其抗剪切能力与洞形有密切关系。     

Drugs for pain management in dentistry

Pain is one of the most common reasons patients seek dental treatment. It may be due to many different diseases/conditions or it may occur after treatment. Dentists must be able to diagnose the source of pain and have strategies for its management. The ‘3‐D’ principle — diagnosis, dental treatment and drugs — should be used to manage pain. The first, and most important, step is to diagnose the condition causing the pain and identify what caused that condition. Appropriate dental treatment should then be undertaken to remove the cause of the condition as this usually provides rapid resolution of the symptoms. Drugs should only be used as an adjunct to the dental treatment. Most painful problems that require analgesics will be due to inflammation. Pain management drugs include non‐narcotic analgesics (e.g., non‐steroidal anti‐inflammatory drugs, paracetamol, etc) or opioids (i.e., narcotics). Non‐steroidal anti‐inflammatory drugs (NSAIDs) provide excellent pain relief due to their anti‐inflammatory and analgesic action. The most common NSAIDs are aspirin and ibuprofen. Paracetamol gives very effective analgesia but has little anti‐inflammatory action. The opioids are powerful analgesics but have significant side effects and therefore they should be reserved for severe pain only. The most commonly‐used opioid is codeine, usually in combination with paracetamol. Corticosteroids can also be used for managing inflammation but their use in dentistry is limited to a few very specific situations.     

中医抗疫故事融入中医药高校思政课教学的探索

中医抗疫故事蕴含的精神价值,契合中医药高校思政课教学要求。要深入挖掘中医抗疫故事的文化内涵、精神内涵和思想内涵,将其转化为中医药高校思政课教学的重要资源。中医抗疫故事融入思政课教学,要做好理论研究、教学设计、载体建设等基础性工作,利用好课堂教学、“战疫小课堂”、实践教学三个课堂,动员教师和学生的积极性。     

茄根含氮类成分及其抗炎活性

目的研究茄Solanum melongena L.根中含氮类成分及其抗炎活性。方法茄根70%乙醇提取物采用MCI、硅胶、ODS、Sephadex LH?20及HPLC等进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。采用LPS诱导RAW264??7细胞模型评价其抗炎活性。结果从中分离得到12个含氮类化合物,分别鉴定为N?acetyltyramine(1)、N?(2?phenylethyl)acetamide(2)、3?(4?aminophenyl)?prop?2?enoic acid(3)、callyspongi?dipeptide A(4)、pistaciamide(5)、tatarine C(6)、thymidine(7)、butyl?2?pyrrolidone?5?carboxylate(8)、indazole(9)、cyclo?[(S)?pro?(R)?leu](10)、seco?[(S)?pro?(R)?val](11)、(L)?pro?(L)?phe(12)。化合物4、8、10~12对LPS诱导RAW264.7产生NO具有良好的抑制作用,其IC50值分别为(33.7±1.4)、(59.1±4.6)、(28.6±2.1)、(44.7±3.1)、(52.8±3.8)μmol/L。结论所有化合物均为首次从该植物中分离得到,且化合物4、8、10~12具有潜在的抗炎活性。     

Acute and chronic ataxic neuropathies with disialosyl antibodies: A continuous clinical spectrum and a common pathophysiological mechanism

Acute ataxic neuropathies with disialosyl antibodies include Fisher syndrome, ataxic Guillain–Barré syndrome (GBS), and acute sensory ataxic neuropathy. Fisher syndrome and ataxic GBS are more strongly associated with IgG anti‐GQ1b and anti‐GT1a than with anti‐GD1b antibodies, whereas the association is reversed in the case of acute sensory ataxic neuropathy. Chronic ataxic neuropathy with disialosyl antibodies is associated with IgM paraprotein to GD1b and GQ1b, which occasionally reacts with GT1a. The clinical, electrophysiological, and pathological features, along with experimental findings, suggest that acute and chronic ataxic neuropathies with disialosyl antibodies form a continuous clinical and pathophysiological spectrum characterized by a complement‐mediated disruption at the nodal region and are better classified in the new category of nodo‐paranodopathies. Muscle Nerve 49 : 629–635, 2014     

Cytoplasmic 5′‐nucleotidase autoantibodies in inclusion body myositis: Isotypes and diagnostic utility

Introduction: Recent studies have identified circulating immunoglobulin (Ig) G autoantibodies against cytoplasmic 5′‐nucleotidase 1A (cN1A; NT5C1A) in patients with inclusion body myositis (IBM), whose detection provides for an IBM blood diagnostic test. Whether or not anti‐cN1A autoantibody isotypes other than IgG are present in IBM has not previously been reported. Methods: Plasma and serum samples from 205 patients (50 with and155 without IBM) were studied for the presence of IgM and IgA, in addition to IgG, anti‐cN1A autoantibodies using immunoblots and enzyme‐linked immunoassays (ELISAs). Results: IgM, IgA, and IgG anti‐cN1A autoantibodies were detected by ELISA with similar sensitivities (49–53%) and specificities (94–96%), but with differing patterns of autoantibody isotype presence. Combination assays of all 3 autoantibody levels improved diagnostic sensitivity to 76%. Conclusions: In addition to previously recognized IgG anti‐cN1A autoantibodies, IBM patients have circulating IgM and IgA anti‐cN1A autoantibodies. Differing patterns of these isotypes may be present and useful for diagnosis. Muscle Nerve 50 : 488–492, 2014