过氧化氢与白癜风

白癜风患者表皮内过氧化氢聚集，氧化压力增大。过氧化氢通过对细胞的直接毒性作用、干扰表皮细胞生物喋呤代谢和抑制细胞酶功能等多种途径，破坏黑素细胞，使黑素生成障碍：清除表皮过氧化氢，能使白癜风白斑处表皮细胞空泡消失，形态恢复正常，白斑重新着色，因此，过氧化氢与白癜风的发病有着密切的关系。     

白癜风的心理干预治疗作用评估

目的 探讨心理干预治疗在白癜风治疗中的作用.方法 对120例白癜风患者进行心理健康症状自评量表(SCL-90)问卷调查,评价受试者心理健康状况.有心理问题的66例随机分为Ⅰ、Ⅱ组,无心理问题的54例随机分为Ⅲ、Ⅳ组.Ⅰ、Ⅲ组采用心理干预+药物+光疗,Ⅱ、Ⅳ组为单纯药物+光疗治疗,疗程3个月,评价疗效同时再次进行心理测评,计算4组治疗方案的P值,评价患者心理问题的改善和皮损好转显效率的对应程度.结果 Ⅰ组与Ⅱ组对比,显效率差异有统计学意义(P＜0.05);Ⅲ与Ⅳ组对比,显效率差异无统计学意义(P＞0.05);Ⅰ组与Ⅲ组对比,显效率差异有统计学意义(P＜0.05);Ⅱ组与Ⅳ组对照,显效率差异无统计学意义(P＞0.05).结论 对白癜风患者进行心理干预治疗,有助于提高早期疗效和生活质量.     

卡介菌多糖核酸对白癜风免疫调节作用及疗效的研究

目的探讨卡介菌多糖核酸(BCG-PSN)对白癜风的免疫调节作用及疗效。方法分别用流式细胞术和ELISA方法检测卡介菌多糖核酸治疗白癜风前后患者外周血T细胞亚群、IL-6和IFN-γ的水平。结果白癜风患者治疗前外周血CD4+百分比及CD4+/CD8+比值下降,CD8+百分比升高,IFN-γ水平降低。卡介菌多糖核酸治疗后,患者CD4+百分比及CD4+/CD8+比值较治疗前升高,CD 8+百分比降低,IFN-γ水平升高(P<0.05),IL-6水平无变化(P>0.05)。治疗组有效率为68.42%,对照组有效率31.58%,两组疗效差异有显著性(P<0.05)。结论卡介菌多糖核酸治疗白癜风可以显著改善患者的细胞免疫功能,提高其治疗有效率。     

白癜风与氧化-抗氧化失衡

白癜风是一种较常见的色素脱失性疾病，临床上以表皮黑素细胞破坏缺失而出现色素脱失斑为主要特征，严重影响患者的外观美容。白癜风的病因学分子机制目前尚无定论，存在多种假说。近年来，对白癜风患者机体抗氧化水平的研究日益增多，越来越多证据提示，机体氧化-抗氧化平衡失调，导致局部微环境中活性自由基大量聚集，引起氧化应激，造成细胞损伤，是引起白癜风发病的一个重要因素。     

Repigmentation d’un vitiligo universalis déclenchée par l’hémodialyse

Vitiligo is an acquired depigmenting disorder. Vitiligo universalis is a rare form responsible for significant aesthetic damage. To date, the exact pathogenesis remains unknown. Its treatment, a real challenge, consists rather in removing the still pigmented areas. We report a case of a patient followed for stable vitiligo universalis from an early age who presented with repigmentation shortly after initiation of hemodialysis.     

Apoptosis of melanocytes in vitiligo results from antibody penetration

Vitiligo is a rather common disease characterized by depigmentation of skin and mucosae due to the loss of melanocytes, most likely as a result of autoimmune phenomena. In this study we demonstrated apoptotic markers in residual melanocytes in skin biopsies of patients with vitiligo, as well as the presence of serum antibodies to melanocyte-specific antigens in the vast majority of patients. Moreover, we were able to prove that serum IgG antibodies from vitiligo patients, but not from healthy controls, were capable to penetrate into cultured melanocytes in vitro, and trigger them to engage in apoptosis. Our results are consonant with the theory that melanocyte-specific antibodies are responsible for the deletion of melanocytes through antibody penetration and apoptosis.     

Blood endotyping distinguishes the profile of vitiligo from that of other inflammatory and autoimmune skin diseases

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Cytokines: the yin and yang of vitiligo pathogenesis

Introduction: Dysregulation of melanocyte function is associated with vitiligo, an idiopathic autoimmune hypopigmentary skin disorder, caused by the selective destruction of melanocytes. Cytokines, the key mediators of immune response, which are pivotal in maintaining immune homeostasis, are crucial in vitiligo pathogenesis. Several studies indicate that there is an imbalance between pro- and anti-inflammatory cytokines in the skin and serum of vitiligo patients.

Areas covered: In this comprehensive review, we have summarized the correlation of cytokine imbalance and vitiligo pathogenesis, its role in melanocyte biology, and its impact on vitiligo treatment. We have integrated various published reports on the levels of major cytokines from skin and serum samples of vitiligo patients. We have also discussed the role of endoplasmic reticulum and oxidative stress on cytokine imbalance and vice versa leading to destruction of melanocytes.

Expert commentary: The review reflects that dysregulation of cytokines is multifactorial, ranging from genetic predisposition to altered protein expression relevant to vitiligo pathogenesis. We emphasize that cytokine imbalance in systemic and skin microenvironment plays a crucial role in vitiligo pathogenesis and has promising potential as therapeutic targets for vitiligo.     

基于玄府理论探析“当归饮子”在皮肤病治疗的应用

目的 观察自拟白驳汤内服联合308 nm准分子光治疗白癜风的临床效果及安全性。方法 选取2020年 1月-2022年1月河西学院附属张掖人民医院门诊诊治的120例白癜风患者为研究对象,采用随机数字表法分为对 照组和观察组,每组60例。对照组给予308 nm准分子光照射治疗,观察组给予自拟白驳汤口服联合308 nm准分 子光照射治疗,比较两组临床疗效及不良反应发生情况。结果 观察组治疗总有效率为88.33%,高于对照组的 61.67%（P＜0.05）;两组均未发生明显长期不良反应。结论 自拟白驳汤内服联合308 nm准分子光治疗白癜风的 临床效果良好,可有效改善患者的临床症状,促进皮肤颜色恢复,且不良反应发生风险较小,安全性较高。     

Abnormal expression of MHC class II and ICAM-1 by melanocytes in vitiligo

The relationship between damage to cutaneous melanocytes and antimelanocyte autoimmunity in vitiligo is unclear. We have demonstrated abnormal expression of MHC class II molecules by perilesional melanocytes in 13/21 patients with vitiligo and a six-fold increase in the number expressing the intercellular adhesion molecule ICAM-1. These molecules have important roles in normal antigen presentation and activation of helper T lymphocytes, and their expression by melanocytes may contribute to the abnormal immune response in vitiligo. MHC class II is not expressed by melanocytes in psoriasis and is unlikely to be induced in vitiligo by cytokines released from activated non-melanocyte-specific T lymphocytes.