Serum homocysteine, vitamin B12, folic acid levels and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in vitiligo

The aim of this study was to determine serum vitamin B12, folic acid and homocysteine (Hcy) levels as well as MTHFR (C677, A1298C) gene polymorphisms in patients with vitiligo, and to compare the results with healthy controls. Forty patients with vitiligo and 40 age and sex matched healthy subjects were studied. Serum vitamin B12 and folate levels were determined by enzyme-linked immunosorbent assay. Plasma Hcy levels and MTHFR polymorphisms were determined by chemiluminescence and real time PCR methods, respectively. Mean serum vitamin B12 and Hcy levels were not significantly different while folic acid levels were significantly lower in the control group. There was no significant relationship between disease activity and vitamin B12, folic acid and homocystein levels. No significant difference in C677T gene polymorphism was detected. Heterozygote A1298C gene polymorphism in the patient group was statistically higher than the control group. There was no significant relationship between MTHFR gene polymorphisms and vitamin B12, folic acid and homocysteine levels. In conclusion, vitamin B12, folate and Hcy levels are not altered in vitiligo and MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo.     

几种色素减退性疾病的研究进展

色素减退性疾病是皮肤科常见的疾病,严重影响美观.白癜风、无色素痣和进行性斑状色素减少症等色素减退性疾病的发病机制、组织病理和治疗不尽相同,但均以色素脱火斑为主要特征,临床鉴别有时较为困难.概述这几种色素减退性疾病的发病机制、临床表现、组织病理及治疗等方面的最近研究进展,以提高对色素减退性疾病的认识,帮助临床诊断与治疗.     

维阿露联合丙酸氟替卡松软膏治疗白癜风疗效观察

目的观察维阿露联合丙酸氟替卡松软膏治疗白癜风的临床疗效和安全性。方法将62例稳定期白癜风患者随机分为3组，试验组外用维阿露联合丙酸氟替卡松软膏，对照1组外用维阿露，对照2组单用丙酸氟替卡松软膏。结果试验组、对照1组、对照2组的有效率分别为81．9％、45．0％、40．0％。试验组与对照1组、对照2组差异均有统计学意5C（P〈0．05）；各组间痊愈率比较，差异均无统计学意义（P〉0．05）。就部位而言，试验组头面部有效率优于躯干部（P〈0．05），头面部有效率显著优于四肢（P〈0．01）。试验组与对照组药物相关不良反应发生率无差异（P〉0．05）。结论维阿露联合丙酸氟替卡松照射治疗白癜风有效。     

黑故子酊对白癜风的作用

白癜风属中医"白癜"、"白驳风"的范畴。主要由于酪氨酸酶缺乏,而不能合成黑色素,致使局部皮肤色素脱失,病程长,可持续终身,易诊难治。临床表现为皮损局部呈乳白色,毛发也可变白。好发于面部、颈部、手背、腰骶部及会阴部等。本文报道中药方剂黑故子对其治疗的效果及机制。     

A Case of Vitiligo after Kawasaki's Disease

Vitiligo is a common skin disease, but its pathogenesis has not been fully determined, though an autoimmune etiology is considered likely. Kawasaki disease (KD) is an acute multisystem vasculitis of childhood associated with coronary arteriopathy, and is diagnosed based on clinical criteria. Furthermore, vitiligo has been associated with several other diseases, but no report has been issued about the relationship between vitiligo and Kawasaki''s disease. The author''s report the case of an 8-year-old male child that presented with depigmented lesions, which developed from the desquamative skin lesions of Kawasaki''s disease.     

基于中药“色象”理论构建白癜风分期论治体系初探

白癜风临床缺乏优化系统的诊疗方案,直接影响疗效的评价与疗效的提高;＂色象＂理论是杨柳教授根据中医长期治疗色素病的临床实践结合现代中药色素代谢研究而首次立论;以中药＂色象＂理论为指导构建白癜风规范化论治体系,具有重要的临床意义。     

2味治疗白癜风中药的有效单体成分鉴定

目的:探讨补骨脂和女贞子2味中药治疗白癜风的有效单体成分,为临床合理用药提供参考依据。方法:采用不同提取方法提取样品,以薄层色谱(TLC)法进行定性鉴别。结果:TLC法检出补骨脂中含有山柰素、柚皮素、补骨脂素、异补骨脂素、阿魏酸和齐墩果酸;女贞子中含有山柰素、柚皮素、阿魏酸和齐墩果酸。结论:所建方法简便、可靠、重现性好,证实了2味中药含有多种激活酪氨酸酶活性的单体化合物。     

供皮区UV-N光照射后自体表皮移植治疗白癜风的临床观察

目的观察供皮区UV—N光照射后自体表皮移植治疗白癜风的临床疗效。方法将符合入选标准的31例患者随机分2组,治疗组供皮区采用UV—N光照射后,再行负压吸疱自体表皮移植术进行治疗,对照组单纯采用负压吸疱自体表皮移植术进行治疗。结果两组疗效比较,X^2=26．04,P〈0．01;两组色素细胞总成活率比较,X^2=6．601,P〈0．05;两组特殊部位色素细胞成活率比较,X^2=6．085,P〈0．05;两组非特殊部位色素细胞成活率比较,X^2=0．24,P〉0．05。移植后皮损处色素出现时间均数方面,两组特殊部位比较,t=5．85,P〈0．01;两组非特殊部位比较,t=6．75,P〈0．01。结论供皮区UV—N光照射后自体表皮移植治疗白癜风,可提高移植色素细胞成活率,缩短疗程,提高疗效,特别适用于特殊部位白癜风的表皮移植术。     

白癜风危险因素1∶1配比病例对照研究

目的　探讨影响白癜风发病环境中可能的危险因素。方法　运用 1∶1配比病例对照研究方法 ,使用单因素Logistic回归分析和多因素条件Logistic回归模型进行分析。结果　单因素分析结果显示 :饮酒 (OR =2 99)、精神紧张 (OR =2 19)、饮食不规律 (OR =4 3 7)、喜食辛辣 (OR =3 83 )、外伤 (OR =2 5 8)、经常接触农药 (OR =3 2 1)、接触油漆原料 (OR =3 0 2 )与白癜风发病呈正相关 ,适度阳光照射 (OR =0 81)、常吃蔬菜水果 (OR =0 72 )呈负相关 ;多因素条件Logistic回归模型分析表明饮酒 (OR =3 985 )、精神紧张 (OR =4 19)、喜食辛辣 (OR =5 83 )、外伤 (OR =1 73 )是白癜风发病危险因素 ,适度阳光照射 (OR =0 71)是一种负面因素。结论　饮酒、精神紧张、喜食辛辣、外伤是白癜风发病潜在环境危险因素 ,适度阳光照射则是一种负面因素     

过氧化氢与白癜风

白癜风患者表皮内过氧化氢聚集，氧化压力增大。过氧化氢通过对细胞的直接毒性作用、干扰表皮细胞生物喋呤代谢和抑制细胞酶功能等多种途径，破坏黑素细胞，使黑素生成障碍：清除表皮过氧化氢，能使白癜风白斑处表皮细胞空泡消失，形态恢复正常，白斑重新着色，因此，过氧化氢与白癜风的发病有着密切的关系。