肝动脉注射阿霉素温度敏感脂质体的制剂研究

自Yatvin等创造温度敏感脂质体以来,许多研究结果证明它是靶治疗的良好载体。Chuang等认为根据荷瘤肝脏的血流分布,设想将温度敏感脂质体通过肝动脉注射滞留于肝动脉,结合人为控制释放脂质体中所包封的药物,有可能提高肝脏肿瘤中的药物浓     

基于网络的病人体温测量系统的研究

本文阐述了基于医院HIS系统平台的住院病人体温自动测暮系统，通过该系统的研究，可以为医院护理工作提供快捷便利的信息化平台，减少护理工作的劳动强度，提高护理质量     

Changes in body temperature and urinary cortisol after routine immunization in babies with intrauterine growth retardation

Aim : To investigate whether infants with intrauterine growth retardation (IUGR) experience different changes in temperature and cortisol excretion after routine immunization compared with normal healthy infants. Methods : Overnight deep body temperature and urinary cortisol to creatinine ratios were measured on the night after immunization and a control night in normal and IUGR infants. Results : In 60 normal infants, first vaccination at about 10 wk of age led to a significant increase in minumum overnight temperature compared to the control night, mean rise 0.25°C (95% CI, 0.12 to 0.38). In 35 IUGR infants the mean rise in temperature between immunization night and control night was 0.35°C (95% CI, 0.15 to 0.55). The increases in minimum temperature did not differ significantly between the normal and IUGR infants ( p = 0.11). Cortisol to creatinine ratios measured from overnight urine samples showed that 23 IUGR infants had consistently higher levels than 39 normal infants; control night medians 34 and 15 ( p = 0.01) and immunization night medians 56 and 26 ( p= 0.02), respectively. However, the percentage increase did not differ significantly between the IUGR infants and the normal infants. A smaller number of second immunizations were studied, but no significant differences were found.

Conclusion : These results suggest that although the impact of immunization is the same for IUGR and normal infants, because IUGR infants are less mature and at greater stress before immunization, the absolute levels that they experience after immunization are higher than those for normal infants.     

山茱萸果实的形成及其温度效应研究

目的:观察山茱萸果实的形成,研究温度对山茱萸开花结实习性的影响,为指导山茱萸的GAP基地建设提供参考。方法:对山茱萸的物候期进行定株观察,确定山茱萸的不同生长时期。结果:首次划分了山茱萸7个生长时期:蕾期、小花开放期、座果保果期、果实迅速生长期、果实缓慢生长期、果实内部充实期和果实成熟期。结论:山茱萸的开花和结实习性与温度相关性强,生产中应根据温度的变化,采取调控措施,确保山茱萸优质、丰产。     

温度对体外精子活力的影响

将42名生育力男子的精液置于17°～37℃间的4组不同温度下检查精子活力,以探讨温度对体外精子活力的影响。结果表明:温度对精子前向运动和活动精子百分率有显著影响,而前向运动级别比活动精子百分率对温度的敏感性更高。36～37℃精子活力最好。24°～25℃组与36°～37℃组之间,精子前向运动级别(0～Ⅲ级制)和活动精子百分率的差异无统计学意义。低于24℃则活力下降。文章认为精液常规和有关精子活力的检查宜在24℃以上进行,需要发挥精子活力的实验宜在37℃左右进行。     

Thermal effects on long-term potentiation in the hamster hippocampus

Extracellular CA1 pyramidal cell activity was measured at different temperatures in hippocampal slices from the Syrian hamster (Mesocricetus auratus), a hibernator. Control records taken before and after tetanic stimulation of Schaffer collateral/commissural pathways were compared to determine if long-term potentiation (LTP) was established. LTP (an enhancement of the population spike amplitude or population synaptic response following tetanus) was elicited in slices at temperatures above 22 °C, but not in slices at temperatures of 20 °C. When LTP was established at temperatures above 24 °C, however, lowering the temperature to 20 °C did not abolish the LTP. Furthermore, when a tetanus was delivered at 20 °C and the bath temperature was then raised above 22 °C, LTP was established. These results for step changes in temperature suggest that the sequence of cellular mechanisms leading to LTP is activated, but then arrested in slices maintained at a constant temperature of 20 °C. Assuming this type of activity in the slice parallels in vivo hippocampal activity, it follows that the ability to elicit LTP in CA1 hippocampal pyramidal cells is lost when the core temperature of an animal entering hibernation falls to 20 °C.     

Further findings on the mechanism of cadmium uptake by intestinal mucosal cells (step 1 of Cd absorption)

This work confirms and extends earlier studies on the mechanism of Cd uptake (step 1 of absorption) by the jejunal mucosa of the rat. The Q₁₀ for step 1A, the binding of Cd to the membrane, approximates 1.0. Internalization of bound Cd (step 1B) exhibits a constant Q₁₀ of 1.4 between 0 and 37°C, providing no evidence for a phase shift in the membrane in that range. Chelators which compete for Cd with the membranes thereby inhibit step 1. Membrane-bound Cd behaves kinetically as a single pool, even though only 1/3 participates in step 1B. Binding does not involve reactive -SH groups. Fractional uptake of 5 μM ¹⁰⁹Cd is equally depressed by 250 μM Cd or Zn; the non-specific apparent saturation of Cd uptake can be explained by charge neutralization on the membrane, and does not require postulation of Cd carriers. These findings support the proposed model of jejunal Cd uptake.     

办公室装潢后室内空气甲醛含量的变化趋势

目的 研究装潢后办公室内空气中甲醛含量的变化趋势。方法 选定7间同时装潢了3个月后的办公室，每隔1．5个月监测1次室内空气中甲醛浓度，同时测室温，连续监测5次。结果 装潢3个月后至10个月，室温从14℃降到10℃，后又回升到26℃，室内甲醛平均浓度从0.22mg/m^3下降到.09mg/m^3后又回升到0.22mg/m^3；超标率从57．1％下降到0，又回升到85．7％。结论 监测期间，办公室内中甲醛含量未随装满后时间延长而降低,而是随着室温的改变而发生相应变化，且有些室内空气中甲醛含量明显超过国家卫生标准。     

三株大肠杆菌在低营养水中菌密度变化的比较

目的：探讨3株大肠杆菌在4种温度下于低营养水体中菌密度随保存时间变化的规律性及其对实际工作的意义。方法：选用大肠杆菌标准株ATCC25922、8099及从人类粪便分离的野生型大肠杆菌，分别配制成一定菌密度的模拟水样，置于恒温水浴箱中，控温在5，15，25，35℃4个水平，以滤膜荧光法定量检测其菌密度的变化。结果：大肠杆菌在低营养水中不繁殖，菌密度随时间的变化在不同温度下均呈负指数函数关系，y=ae^-bt，在相同温度条件下，ATCC25922菌密度下降最快，野生株次之，8099株最慢，不同温度下其规律为35℃下降最快，25℃次之，15℃最慢。结论：不同菌株大肠杆菌在低营养水体中的菌密度变化各不相同，与菌体、环境温度以及保存时间关系密切。