Erdheim-Chester病胸部受累:CT成像结果及其与BRAF~(V600E)突变的关系

正摘要目的探讨Erdheim-Chester病(ECD)的胸部CT表现并评估其与BRAF~(V600E)突变的关系。方法对行胸部CT成像的ECD病人(61例,其中男46例)进行前瞻性研究。由     

在钆塞酸增强MRI中通过肝细胞摄取率来定量评价肝功能

正目的探讨源于钆塞酸增强MRI的肝细胞摄取率是否与肝功能的定量测量有关,并帮助识别大范围肝切除术的禁忌证。材料与方法在2016年8月—2016年10月期     

接受经皮穿刺动脉栓塞术的大型多中心队列研究中自发性软组织血肿死亡率的预测因子

正摘要目的评价经皮动脉栓塞(PTAE)治疗自发性软组织血肿(SSTH)的安全性和有效性,并确定短期预后的预测变量。材料与方法对2011—2017年期间的112例病人的临     

Using organotypic hippocampal slice cultures to gain insight into mechanisms responsible for the neuroprotective effects of meloxicam: a role for gamma aminobutyric and endoplasmic reticulum stress

<正>This perspective aims to put into context the recent article by Landucci et al.(2018)on mechanisms involved in the neuroprotective effects of meloxicam on an organotypic hippocampal slice cultures(OHSCs)model.In vitro cell cultures are the main method for studying large quantities of homogeneous cells in an isolated environment.Thus,the use of primary dissociated neuron,astrocyte,oligodendrocyte,microglia,or endothelial cell cultures has become a standard method     

RECIST版本1.1对转移瘤反应评估的有效性:一项前瞻性多阅片人研究

正目的采用实体瘤疗效评价标准(RECIST)v1.1确定靶病变选择与转移性癌行全身细胞毒性和/或靶向治疗病人的治疗反应分类之间的相关性。材料与方法该前瞻性多     

双能CT虚拟平扫对肾脏病变定性的影响

正摘要双能(DE)CT可从单时相对比剂CT增强检查中重建虚拟非对比剂(VNC)影像,这样可能减少多时相CT增强对肾脏病变定性的需求。然而,关于VNC影像用于诊断肾     

电针治疗突发性耳聋伴耳鸣、焦虑及睡眠障碍临床研究

目的:探讨电针治疗突聋伴耳鸣及焦虑失眠症状的治疗效果。方法:将单侧突聋伴耳鸣患者70例分为药物组和针药组,药物组35例,针药组30例,脱落5例。以耳鸣残疾量表评分(THI)、耳鸣程度评级检测、焦虑量表(SAS)、睡眠量表(PSQI)评价治疗效果。结果:针药组和药物组在治疗突发性耳聋患者的听力损伤上中低频改善有统计学差异(P 0. 05),在耳鸣治疗疗效上,针药组优于药物组(P 0. 05),在改善焦虑及睡眠症状上,针药组优于药物组(P 0. 05)。结论:针药结合对突聋患者的听力损伤有效,尤其是对伴有耳鸣和焦虑睡眠症状的突聋疗效好于药物治疗。     

心血管MRI评估主动脉瓣狭窄病人的主动脉弹性:比较二叶型和三叶型主动脉瓣

正摘要目的比较二叶型主动脉瓣(BAV)和三叶型主动脉瓣(TAV)的主动脉瓣狭窄(AS)病人在MRI上的主动脉大小和弹性参数。方法 174例无症状中-重度AS病人[平均     

From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?

Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.Clinically,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons.Current treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal damage.Therefore,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease.For instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell death.Despite the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative process.Therefore,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based strategies.Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic neurons.Such approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease.Thus,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease.     

Exploring the potential application of dental pulp stem cells in neuroregenerative medicine

The trigeminal nerve and its peripheral branches are susceptible to injury in the dental practice due to surgical removal of impacted third molars and placement of dental implants.Although peripheral trigeminal nerve injuries can undergo spontaneous regeneration,some injuries may be permanent with varying degrees of continued sensory impairment and neuropathic pain ranging from mild numbness to complete anaesthesia(Tay and Zuniga,2007).Adult neurons require continued neurotrophic support from surrounding cells to sustain neural viability,inhibit death-inducing pathways activating a variety of cell survival pathways(Zheng and Quirion,2004).