白芥子不同配比穴位贴敷防治支气管哮喘的皮肤反应及疗效分析

目的:研究白芥子不同配比穴位贴敷防治支气管哮喘所出现的皮肤反应与疗效之间关系。方法:将所纳入的90例支气管哮喘患者随机分为A、B、C 3组,每组30例。贴敷药物中除白芥子外,余药相同。A组全部为生白芥子,B组生白芥子、炒白芥子各半,C组全部为炒白芥子。三伏天穴位贴敷,每伏贴敷一次,共3次。观察由不同配比白芥子而引起的皮肤反应以及各组疗效。结果:穴位贴敷后A、B、C3组皮肤反应积分依次降低,3组皮肤反应差异有统计学意义(P<0.05),A、B、C3组临床总有效率分别为93.33%、90.00%、73.33%,3组疗效组间比较无显著差异(p>0.05)。结论:穴位贴敷防治支气管哮喘是一种行之有效的方法,随生白芥子比例增加3组患者皮肤反应逐渐加重,但并非皮肤反应越强疗效越显著,适度的皮肤反应即可达到良好的疗效。     

丹益片联合低频脉冲治疗仪治疗Ⅲ型前列腺炎伴早泄的临床观察

目的:探讨口服丹益片联合低频脉冲治疗Ⅲ型前列腺炎合并早泄的临床疗效。方法:选取240例符合Ⅲ型前列腺炎合并早泄诊断标准患者为研究对象,随机分为口服丹益片联合低频脉冲治疗组(研究组)、丹益片药物治疗组(对照1组)和低频脉冲治疗组(对照2组),每组80例,治疗4周,记录各组治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分及阴道内射精潜伏期(IELT)。对比分析三组患者治疗前后的NIH-CPSI评分及IELT,比较三组治疗的显效率。结果:研究组、对照1组、对照2组治疗前NIH-CPSI评分分别为(28.6±5.3)、(27.6±5.1)、(28.5±4.9)分,治疗后分别减低为(11.4±2.3)、(18.5±3.1)、(19.4±3.3)分(P0.05)。三组治疗前的IELT分别为(0.81±0.16)、(0.74±0.15)、(0.82±0.17)min,治疗后分别延长为(5.81±0.96)、(3.74±0.85)、(3.12±0.87)min(P0.05)。显效率分别为80%、60%、45%(P0.05)。结论:口服丹益片联合低频脉冲对于Ⅲ型前列腺炎合并早泄取得较好疗效,且比单独丹益片药物治疗或单独使用低频脉冲治疗所取得的临床疗效更好。     

穴位埋线对颈椎病疗效的影响

目的：探讨穴位埋线、中医汤药和按摩对颈椎病的治疗作用。方法将120例颈椎病患者随机分为穴位埋线组（40例）、中医汤药组（40例）和按摩组（40例）。穴位埋线组通过对颈项部相关穴位埋线进行治疗;中医汤药组以葛根汤加减进行治疗;按摩组是以舒经活血、理筋整复进行治疗。观察颈椎病症状消失时间的长短、愈后在一定时间内有无复发。结果穴位埋线组痊愈率为90％,中医汤药组痊愈率为85％,按摩组痊愈率为75％。穴位埋线组优于中医汤药组和按摩组,并缩短患者的治疗时间、减少患者复发的次数、医疗费用。结论穴位埋线组可以显著改善颈椎病,促进颈椎病的康复。     

大黄贴敷联合复方聚乙二醇电解质散口服对便秘患者肠道准备给药时机的影响

目的探讨大黄贴敷神阙穴和天枢穴联合口服复方聚乙二醇电解质散(PGEP)在便秘患者肠道准备中的给药时机。方法选择行结肠镜检查的便秘患者300例,分3组,各100例。A组检查前1天晚上9点,行中药贴敷神阙穴和天枢穴,检查当天早上5~7点服完PGEP 139.12 g(2 000 ml);B组检查前1天晚上9点行中药贴敷神阙穴和天枢,检查当天上午10~12点服完相同剂量的PGEP;C组检查当天早上5点行中药贴敷神阙穴和天枢穴,早上5~7点服完相同剂量的PGEP。服药后4 h行结肠镜检查。应用Boston肠道准备量表(BBPS)评分,并对肠腔内气泡进行评分,比较3组患者肠道准备有效性、耐受性及安全性。结果 A组的肠镜检查时间(7.25±0.60)min明显短于B组(9.10±0.80)min和C组(10.50±0.55)min;A组的BBPS评分(8.50±0.35)分明显高于B组(7.35±1.25)分和C组(6.65±1.30)分;A组的肠腔内气泡评分(0.25±0.15)分明显低于B组(0.75±0.65)分和C组(0.55±0.50)分;A组肠道准备接受率、再次肠道准备接受率(96.00%、93.00%)明显高于B组(85.00%、70.00%)和C组(90.00%、88.00%);A组的总体不良反应评分(1.45±0.04)分明显低于B组(1.75±0.55)分和C组(1.60±0.25)分。差异均有统计学意义(P0.05)。结论检查前1天晚上9点大黄穴位贴敷联合检查当天早上5~7点口服PGEP对便秘患者行结肠镜检查肠道准备效果好。     

Acupoint catgut embedding therapy for functional constipation: A protocol for systematic review and meta-analysis

Background:This review will assess current evidence related to the effectiveness and safety of acupoint catgut embedding therapy for functional constipation (FC) and provide efficacy assessments for clinical applications.Methods:We will search the following databases for relevant trials: PubMed, EMBASE OVID, Cumulative Index of Nursing and Allied Health Literature, OVID MEDLINE, Web of Science, the Cochrane Central Register of Controlled Trials, Cochrane library, and Scopus. We will also search the following Chinese databases for trials published in the Chinese literature: China National Knowledge Infrastructure Database (CNKI), Chinese Scientific Journals Database, Wan Fang Database, Chinese Biomedicine and other resources from inception to December 2020. Only randomized controlled trials comparing acupoint catgut embedding versus acupuncture or sham acupuncture or placebo or other therapies will be included. The outcomes involved mean spontaneous bowel movements, complete spontaneous bowel movements, the Bristol Stool Form Scale, the Cleveland Clinic Score, Patient Assessment of Constipation symptom and so on. The risk of bias assessment and quality of evidence for outcomes will be appraised using the Cochrane Risk of Bias Tool and the Grading of Recommendations, Assessment, Development and Evaluation guidelines. RevMan 5.3 software will be employed for the meta-analysis.Results:This work will compare and arrange the comparative efficacy of acupoint catgut embedding with different treatments for FC by summarizing the current evidences.Conclusion:The results of this meta-analysis may help doctors determine the best treatments for patients to manage FC.Ethics and dissemination:This is a protocol with no patient recruitment and personal information collection, approval by the ethics committee is not required.OSF Registration number:DOI 10.17605/OSF.IO/XTKE2.     

The study on the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of nerve root sciatica: A protocol for systematic review and meta-analysis of randomized controlled trials

Background:Nerve root sciatica (NRS) is a common orthopedic disease, which usually occurs between 20 and 40 years of age, and the incidence rate is increasing year by year and is being younger. The disease has no special effect of treatment, clinically generally taking the symptomatic treatment, such as taking short-term glucocorticoids, sedatives, analgesics, and so on. Long-term use of drugs will adversely affect the patient''s gastrointestinal tract, liver, and kidney function. The surgical treatment has a high risk of surgery, high cost, side effects, and other problems, so the choice of treatment method has always been a difficult problem in clinical and scientific research. The study shows that 90% of patients with sciatica can be cured by non-surgical treatment, so conservative therapy is often used in the treatment of sciatica, traditional Chinese medicine treatment methods in the treatment of NRS has been widely used, which has achieved good results, but there is no evidence of evidence-based medicine. Therefore, this study uses systematic evaluation to conduct the scientific evaluation of the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of NRS, and provide evidence-based medical evidence support for the treatment of NRS.Methods:Using the computer to retrieve the PubMed, ScienceDirect, Web of Science, Embase, Cochrane Library, CNKI, VIP, WANFANG Database, and CBM. Using the subject words and terminology words to retrieve the Chinese-English database and retrieve a randomized controlled study on the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of NRS, and the range of search time is January 1990 to January 2021. The searched literature is screened and evaluated by two researchers respectively according to the inclusion and exclusion criteria. If there is disagreement, discussing it with the third researcher to determine the final inclusion of the literature. Using the RevMan 5.3 software to conduct the meta-analysis.Results:This study will compare the effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of NRS.Conclusion:The results of this study will be published in internationally influential academic journals to provide evidence-based medical evidence for the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding in the treatment of NRS.Ethics and dissemination:This study does not involve specific patients, and all research data comes from publicly available professional literature, so an ethics committee is not required to conduct an ethical review and approval of the study.OSF registration number:DOI 10.17605/OSF.IO/Q492E.     

电针结合穴位敷贴治疗肛肠手术后便秘临床观察

目的观察电针结合穴位敷贴治疗肛肠手术后便秘的临床疗效。方法 100例肛肠手术后便秘患者随机分为两组。治疗组采用针刺双侧天枢、足三里、上巨虚,同时在两侧天枢及上巨虚采取电针治疗,治疗30min后,将中药敷贴贴于神阙穴上;对照组采用开塞露灌肠治疗。2个疗程后比较两组治疗效果,及治疗前后排便次数、排便困难程度的变化。结果治疗组总有效率与对照组比较有明显差异(P0.05);治疗后两组排便次数较治疗前有明显变化(P0.05);治疗组治疗后排便困难程度积分较治疗前比较有明显差异(P0.05),对照组无明显变化。结论电针结合穴位敷贴是一种治疗肛肠手术后便秘的有效方法。     

本经取穴调控无先兆偏头痛患者基因表达谱的研究

【目的】研究针刺少阳经穴与针刺非经非穴治疗无先兆偏头痛患者前后的基因表达谱。【方法】采用基因芯片技术,分析比较采用经穴（经穴组）和非经非穴（非经非穴组）治疗无先兆偏头痛患者（各10例）后基因表达谱的差异;选取部分基因进行Real-time聚合酶链反应（RT－PCR）,验证基因芯片结果的准确性。【结果】经穴组治疗前后筛选出72个差异基因;非经非穴组治疗前后筛选出110个差异基因。经穴组差异基因涉及的功能包括脑内啡肽酶、 ATP合酶等,与治疗该病的关联性大。但非经非穴组涉及的基因功能广泛且分散,与治疗该病关联性较小,如细胞凋亡、 DNA修复等。 RT－PCR检测了经穴组的ATPAF2、 PTGS2、 TOR3A基因,非经非穴组的ACP2、 AURKA、 ARHGEF11、 CASP8基因,验证了基因芯片数据的可靠性。【结论】本经取穴治疗无先兆偏头痛的经穴效应在分子水平是多基因作用的综合结果,而非经非穴产生的安慰效应并未找到与之对应的与治疗无先兆偏头痛相关的靶基因,进一步证明了经穴效应的存在。     

表里经配穴法对脑缺血再灌注损伤大鼠海马细胞凋亡及JNK信号通路的影响

【目的】观察表里经配穴法对脑缺血再灌注损伤大鼠海马细胞凋亡及c－jun氨基末端激酶（JNK）信号通路的影响,探讨其对脑缺血再灌注损伤保护作用的可能机制。【方法】将120只SD大鼠随机分为假手术组、模型组、表里经配穴电针组、抑制剂组;参照Longa法复制局灶脑缺血再灌注模型,表里经配穴电针组取表里经配穴的足三里、三阴交和尺泽、合谷行电针治疗,每日1次。采用神经行为学评定各组大鼠不同时段神经行为, TUNEL法检测海马细胞凋亡指数,免疫组织化学法检测p－JNK表达。【结果】表里经配穴电针组、抑制剂组神经功能缺损评分均显著低于模型组（P＜0．05）;模型组凋亡指数显著高于假手术组（P＜0．01）,表里经配穴电针组和抑制剂组凋亡指数均显著低于模型组（P＜0．05）;模型组各时段p－JNK表达较假手术组显著增加（P＜0．01）,表里经配穴电针组、抑制剂组p－JNK表达较模型组显著降低（P＜0．05）。【结论】表里经配穴法可不同程度地减轻缺血再灌注后大鼠的神经功能缺损,减少细胞凋亡,其机制可能与抑制JNK信号通路有关。