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71.
本文对43例经心导管证实的空间隔缺损患者进行了多因素逐步回归分析,发现在23项临床参数中,对肺动脉压有显著影响的因素,依次为红细胞压积、周围血管征、空间隔缺损大小、心脏杂音强度、心胸比率(r=0.8028),并初步探讨了各因素对肺动脉压的影响机制,旨在能非创伤性地动态了解患者肺动脉压力,为临床工作提供参考依据。 相似文献
72.
We report a case of V ventricular cystic dilatation, presenting with specific neurological symptoms including low back pain, bilateral sciatica, weakness of dorsiflexion, and urinary retention. MRI showed a large cystic dilatation of the ventriculus terminalis. Surgical fenestration of the cyst allowed complete relief from symptoms and remission of the neurological deficit. 相似文献
73.
观察室性早搏43例,多普勒频谱表现为峰值流速减慢,早搏使前一组A峰消失,后一组峰值流速增快。19例早发型,主动脉瓣口、肺动脉瓣口无频谱出现,早搏每搏量因发生时间不同,每搏量减少不同,晚发型平均减少37.6%,早发型平均减少79.6%。讨论了产生机理及对心排量的影响。 相似文献
74.
自制非对称型室间隔缺损封堵器的初步临床应用 总被引:10,自引:2,他引:8
目的 评价自制非对称型室间隔缺损 (VSD)封堵器经导管闭合VSD的可行性及疗效。方法 16例患者经临床体检、心脏超声检查诊断为先天性心脏病 ,膜周部VSD。术前超声测量缺损直径 3~ 8(4 .31± 1.35 )mm。在X线透视和经胸超声引导下通过F6~ 8长鞘置入封堵器。结果 左心室造影测量VSD直径为 3~ 8(4 .6 3± 1.5 9)mm。VSD上缘距主动脉瓣 1~ 6 (3.31± 1.19)mm。植入封堵器腰部直径为 4~ 16 (6 .19± 1.91)mm。 14例封堵器到位后 15min左心室造影示无分流 ,2例少量分流。术后 1周经胸超声检查无分流 ,术中及术后无并发症。结论 应用自制非对称型VSD封堵器治疗膜周部VSD安全、有效。远期疗效尚需进一步随访观察。 相似文献
75.
目的观察左心室舒张功能新指标测定的意义。方法应用脉冲多普勒技术测定高血压病Ⅰ期(20例)、高血压病伴左心室肥厚(22例)、高血压病伴有房颤(14例)及25例正常人二尖瓣口及瓣下1cm、2cm、3cm左心室内不同部位的舒张早期充盈速度(E0、E1、E2、E3),计算E1/E0、E2/E0、E3/E0比值。结果高血压病人E3显著降低,E3/E0与自身E2/E0相比有显著差异(P<0.01),且E3/E0与常规测定舒张功能指标E/A法有良好的相关性。高血压病Ⅱ组与高血压病Ⅰ组相比,舒张功能障碍更为明显。结论高血压病早期即有左心室舒张功能减退,并出现于心室功能障碍之前,且左心室舒张功能减退随心肌受损加重而明显。E3/E0法是反映左心室舒张功能障碍的良好指标,可弥补E/A法的不足。 相似文献
76.
吡那地尔对高血压心脏结构和功能重构的影响 总被引:5,自引:0,他引:5
在等降压剂量下吡那地尔和赖诺普利可使4月龄自发性高血压大鼠的血压下降6.0 ̄8.0kPa,并接近同种属正常血压大刀瓣血压水平。 相似文献
77.
Hikaru Matsuda Yoshiyuki Taenaka Nobukazu Ohkubo Masakatu Ohtani Kyouichi Nishigaki Shigeaki Ohtake Takuya Miura Nobuyuki Taenaka† Hisateru Takano Hajime Hirose Yasunaru Kawashima 《Artificial organs》1988,12(5):423-430
Pneumatic ventricular assist device (VAD) was utilized for cardiogenic shock after intracardiac operation in two children with complex cardiac anomalies based with single ventricle. In the first case (a 10-year-old), after a modified Fontan operation, VAD was placed between the functional left atrium and ascending aorta, serving as a "artificial single ventricle" with neither pumping chamber nor artificial support in the right side of the heart. The systemic circulation was maintained by keeping relatively high central venous pressure. In another child (a 3-year-old) who underwent repair of incompetent atrioventricular valve leaving intracardiac lesions, VAD was placed between the common atrium and ascending aorta, serving as a pump for both pulmonary and systemic circulation with regulation of pulmonary blood flow through an aortopulmonary Gore-Tex shunt. The circulatory assist with VAD was utilized for 5 and 6 days, respectively. Although weaning from the device was not feasible in both patients because of the pulmonary dysfunction, these experience showed the possible use of VAD for cardiogenic shock after surgery in patients with complex cardiac anomalies. 相似文献
78.
Caffeine exerts a number of different effects on L-type calcium current in rat ventricular myocytes. These include: (1) a slowing of inactivation that is comparable to, but not additive to, that produced by prior treatment of the cells with ryanodine (a selective sarcoplasmic reticulum Ca2+ releaser) or high concentrations of intracellular 1,2-bis[2-aminophenoxy]ethane-N,N,N,N-tetraacetic acid (BAPTA) (a fast Ca2+ chelator), (2) a stimulation of peak I
Ca that is comparable to, but not additive to that produced by prior treatment with isobutylmethylxanthine (a selective phosphodiesterase inhibitor), and (3) a dose-dependent decrease of peak I
Ca that is not prevented by pretreatment with any of these agents. None of the caffeine actions could be mimicked or prevented by administration of 8-phenyltheophylline, a specific adenosine receptor antagonist. We conclude that only the slowing of I
Ca inactivation is due to caffeine's ability to deplete the sarcoplasmic reticulum of calcium. The stimulatory effect of caffeine on peak I
Ca is probably due to phosphodiesterase inhibition, while caffeine's inhibitory effect on I
Ca is independent of these processes and could be a direct effect on the channel. The multiplicity of caffeine actions independent of its effects on the sarcoplasmic reticulum lead to the conclusion that ryanodine, though slower acting and essentially irreversible, is a more selective agent than caffeine for probing sarcoplasmic reticulum function and its effects on other processes.The experimental part of this work was published during the postdoctoral stay of I. Zahradník in the Department of Physiology and Biophysics, The University of Texas Medical Branch, Galveston, TX 77555, USA 相似文献
79.
Dilatational, hypertrophic, aneurysmal, and endocardial variants of remodeling were revealed in the postinfarction heart. The most prevalent dilatational remodeling is characterized by uniform or nonuniform elongation of ventricular cavities and increase in ventricular volume. Characteristic features of the hypertrophic type are hypertrophied interventricular septa and left ventricular wall and reduced or unchanged left ventricular volume. Pronounced changes in the configuration of the left ventricle due to the formation of single or multiple aneurysms were typical of aneurysmal remodeling. Endocardial remodeling was characterized by cicatricial changes and smoothed relief of the parietal endocardium. These variants and forms of remodeling determine disturbances in intracardial hemodynamic and thanatogenesis in the postinfarction period. 相似文献
80.
改变在体兔左心室后负荷对其电生理参数的影响 总被引:3,自引:1,他引:3
目的:探讨改变在体兔左心室后负荷对室性心律失常发生情况及左心室电生理参数的影响。方法:改变左心室后负荷,观察室性心律失常发生情况,并测定左心室舒张阈值(VDT),相对不应期(RRP),有效不应期(ERP)及其不应期离散和心室纤颤阈(VFT)。结果:逐级增加左心室后负荷(AB级)可使左室空间RRP,ERP离散增加(B级,P<005),VFT降低(B级,P<001);各实验动物均出现室性心律失常(B级);而逐级减小左室后负荷(CD级),心室电生理参数无变化(P>005),各实验动物亦无室性心律失常发生。结论:增加左心室后负荷诱发室性心律失常,与左室空间不应期离散增加有关。 相似文献