卡巴胆碱对烧伤延迟复苏大鼠免疫功能的影响

Objective To explore the changing trend of Ia on monocyte, lymphocyte apoptosis rate, TNF-α and IL-6 in abdominal aorta of burned rats with delayed resuscitation and the influence of application of carbachol on them. Methods Adult male Wistar rats were randomly divided into normal control group(n =8), scald group(n =48) and scald with carbachol treatment group(n =48). In latter two groups, rats were inflicted with 30% total body surface area (TBSA) full-thickness scald and delayed fluid resuscitation. All scald rats were sacrificed at the 6th hours or 1st, 2nd, 3rd, 7th, 14th day after scald, with 8 rats at each time point. Expression of Ia antigen on monocyte and lymphocyte apoptosis rate were determined by direct immunofluorescence on a flow cytometer, and TNF-α and IL-6 was measured by ELISA. Results Expression of la on monocyte was obviously lower than that of controls. The lowest levels were recorded on the 6th hours and 1st day after scald. Subsequently, Ia was elevated gradually, but still lower than that of normal rats(P <0. 01). After administration of carbachol, Ia expression was obviously promoted, compared with the simple scald group (P <0. 01). Lymphocyte apoptosis rate, TNF-α and IL-6 was higher than that of controls(P <0. 01). After administration of cavachol, , lymphocyte apoptosis rate and TNF-α and IL-6 was obviously down-regulated on the 6th hours, 1st day, 2nd day and 3rd day after scald injury, compared with the simple scald group (P < 0. 01 or 0. 05). Conclusion After severe burn with delayed fluid resuscitation, there is a low la expression, high lymphocyte apoptosis rate and increased releasing of proinflammatory cytokine. Immune function was suppressed. Carbacho] could improve the immune function of scald rats with delayed fluid resuscitation.     

桂枝汤的临床应用

<正> 桂枝汤一方,源于张仲景《伤寒论》,此方为经方代表方剂之一。综观《伤寒论》、《金匮要略》,仲景立方200余首,其用桂枝者60余方,以桂枝为主药者30方。本方原是用来治疗伤寒太阳表虚证的主方,以其能解肌表之邪,调和营卫。通过临床加减,广泛用于内、外、妇、儿各科,现举例如下。 1 内科—痹证 郑某,女,60岁,汉族。1994年2月诊。患者因右侧肩臂疼痛1年,手指麻木,得温或活动后稍缓解,曾更数医,不效。经详问病史,知其于患病前,因劳作汗出,用冷水洗浴,而致本病。查舌质淡、苔薄白,脉细缓。诊断为痹证。证     

咸秋石的抗炎,退热药理研究

目的：探讨咸秋石的抗炎,退热的药理作用。方法：采用大鼠蛋清足跖浮肿容积法和化学刺激致热退热法,结果：该药和阿斯匹林均具有抑制蛋清性足跖肿胀和缓解大鼠体温升高的作用,且其水煎液（０．８ｇ／ｋｇ和１．６ｇ／ｋｇ）作用效果差别不太,但１．６ｇ／ｋｇ的咸秋石水煎液对大鼠有明显利尿,排便增多的现象,结论：咸秋石具有一定的抗炎,退热作用。     

常饮牛奶及饮食口味偏咸与脑卒中的关系

目的 探讨某些饮食习惯与脑卒中的关系。方法 采用医院为基础的配比病例对照研究方法,对经颅脑CT扫描确诊的320例脑卒中病例及各自的对照通过条件logistic回归程序作1：1配比分析。结果 单因素分析结果表明,经常喝牛奶者脑卒中的OR为0．70（95％CI：0．53－0．92）,口味偏咸使脑卒中的危险性增加,OR为1．42（95％CI：1．06－1．91）。按高血压病史调整后,以上作用均失去显著意义（OR分别为0．59,95％CI：0．29－1．22和1．26,95％CI：0．87－1．82。结论 经常喝牛奶对中老年人脑卒中的发病具有保护作用,口味偏咸可使脑卒中的危险性增加,这些作用可能是借助于对高血压的影响来实现的。未发现饮茶习惯与脑卒中有关。     

治咽喉炎验方

橄榄煲萝卜 取橄榄250克、萝卜500～1000克,煎汤代茶,分次服用。     

药用全蝎中含盐量测定

笔者在基层药品监督检验及中药生产工作中,发现药用全蝎含盐量差异较大。为此,试以Cl-含量为指标,用银量法对药用全蝎含盐量进行了测定,现报道如下。1　供测药材淡全蝎购于济宁市灵芝药业集团,经鉴定为钳蝎科动物东亚钳蝎buthusmartensiikarsch的干燥体。咸全蝎分别抽检于...     

浅析“多食咸”与消渴病发展变化的关系

今时之人,除过食肥甘外,更是味过于咸。“多食咸”可变热、令津泄、动肾气辟精关、令脉凝泣而变色,故而平素嗜咸可加重消渴病阴虚燥热、瘀阻脉络的程度,从而加速消渴病的发展变化。最新研究也显示高盐饮食与糖尿病及相关并发症的发生发展关系密切。治疗方面,依据五行“土克水,甘克咸”可知,甘味药对平素嗜咸的消渴患者具有治疗意义。文章结合古代文献与现代研究拟探讨“多食咸”与消渴病发展变化的关系,为今后预防、调护及结合患者饮食习惯整体辨治消渴病提供新思路。     

2004～2011年间我国9省成年居民咸菜类食物摄入情况分析

<正>咸菜主要是用腌、酱、渍等方法制成,其在我国具有悠久历史,制作工艺也是相当成熟。咸菜为保证其风味及保藏性,含盐量一般都很高。而高盐摄入会带来很多与之相关的慢性疾病,如高盐摄入与肥胖的发生[1]和高血压患病率[2-3]均有较明显关系。此外,妊娠期摄入咸菜泡菜类食品会增加妊娠妇女发生HDCP(妊娠高血压疾病)的风险[4]。     

全蝎的临床应用体会

全蝎为钳蝎科昆虫,东亚钳蝎的干燥全体,产于我国各地,长江以北较多,春秋均可捕捉。捕捉后投沸水中烫死,晾干者,称淡全蝎,加盐煮,晾干者,称咸全蝎。笔者在临床上应用全蝎,效果显著,介绍如下。1肢体麻木麻木是一个症状,可单独出现,亦可见于其他疾病中,但究其主要的病因,不外乎虚实两种。其一,风、寒、湿、热、痰、瘀等邪侵袭机体,闭阻经络,使气血流通不畅,肢体经脉失养而致;其二,由于气血不足,筋脉失荣而发。不论麻木的原因如何,只要有麻木症状,均可配伍或单独使用全蝎,常能收到满意的疗效。患者张××,女,48岁,形体稍胖,双上肢麻木,活动受限,…