热咸饮食对胃粘膜组织中p53基因表达的影响

慢性萎缩性胃炎属于癌前病变,它是胃癌发生的重要环节.建立简单可靠的萎缩性胃炎动物模型并且研究其发生机制,为胃癌及癌前病变的发生机制及对胃癌的预防提供新的依据,是胃癌癌前病变研究的重要课题.     

饮食性味与养生

"民以食为天,食以衡为先",人要活就得吃东西,所以"食是生命的第一要素".饮食是人体营养的主要来源,是维持人体活动的必要条件,而饮食调理得当,就如同有一个保健医生,时刻帮助你提高身体素质,抵御外界的各种疾病.唐代百岁医家孙思邈在<千金要方>中,就指出了饮食及掌握饮食用法的重要性:"安身之本,必资于食……不知食宜者,不足以存生也.""食能排邪而安脏腑,悦神爽志,以资气血,若能用食平苛释情遣疾者,可谓良工,长年饵老之奇法,极养生之术也."     

利多卡因治疗支气管哮喘的临床应用

目的观察利多卡因(LC)治疗重度支气管哮喘(哮喘)74例的临床效果.方法从1994年10月～2003年12月,我院共收集哮喘患者147例,并随机分成8组,其中花草过敏哮喘(PHAA)16例分成4组,COPD诱发哮喘(COPDAA)131例分成4组.1.PHAA(1)哮喘急性发作2组治疗组和对照组各4例(2)哮喘持续状态2组治疗组和对照组各4例.2.COPDAA(1)哮喘急性发作61例分2组①治疗组32例,②对照组29例;(2)哮喘持续状态70例分2组①治疗组34例,②对照组36例.各治疗组以LC为主,各对照组以氨茶咸(Ami)为主.PHAA不配用消炎药物;COPDAA在综合治疗方案应用地塞米松(DE)、青霉素(BEN)和吸氧(Oi)等基础上,治疗组加用LC;对照组加用Ami.LC和AMi疗效判定有效时间限于用药后60min内哮喘终止.结果LC治疗PHAA 8例总有效率为100%;LC治疗COPDAA急性发作32例和哮喘持续状态34例,总有效率分别是71.87%和70.58%.总有效率治疗组显著高于对照组.结论LC是治疗重度哮喘的最理想的首先药物.     

路广晁教授治疗口咸1例

口咸是指不吃咸味食物,而口中自觉有咸味,或时有咸味痰涎排出.现代医学研究口咸由于唾液中钠、钾、钙、镁含量增多所致,多见于西医学的慢性咽喉炎、慢性肾炎、神经官能症或口腔溃疡.在导师路广晁教授门诊上巧遇一口咸为主诉患者,将之记录,希望能对以后研究尽绵薄之力,以下介绍路师治疗该患者经过.     

基于电子舌技术的豨莶草炮制前后滋味比较

目的研究豨莶草炮制前后滋味的变化,建立生、制品豨莶草滋味判别模型。方法通过电子舌测量12批生品豨莶草与12批炮制品豨莶草的酸、苦、涩、咸、甜味值,利用配对t检验、主成分分析(PCA)和线性判别因子分析(LDA)等方法研究豨莶草炮制前后各味道的变化情况。结果通过配对t检验发现豨莶草炮制后,苦、咸味下降,酸、涩、甜没有明显变化;通过PCA可以区分生品与制品豨莶草;通过LDA可以建立生品、制品味道判别模型,并进行交叉验证,正确率达到100%;通过雷达图建立了豨莶草生品与制品的滋味指纹图谱。结论电子舌能够对中药豨莶草的酸、苦、涩、咸、甜味值进行准确的辨识,结合统计方法,可以从数值上体现豨莶草炮制前后滋味的改变,并以此推测豨莶草炮制前后滋味的改变与功效的改变之间的关系。另外,建立的生、制品判别函数模型及雷达图指纹图谱可以用于生、制品豨莶草的判别。     

卡巴胆碱对烧伤延迟复苏大鼠免疫功能的影响

Objective To explore the changing trend of Ia on monocyte, lymphocyte apoptosis rate, TNF-α and IL-6 in abdominal aorta of burned rats with delayed resuscitation and the influence of application of carbachol on them. Methods Adult male Wistar rats were randomly divided into normal control group(n =8), scald group(n =48) and scald with carbachol treatment group(n =48). In latter two groups, rats were inflicted with 30% total body surface area (TBSA) full-thickness scald and delayed fluid resuscitation. All scald rats were sacrificed at the 6th hours or 1st, 2nd, 3rd, 7th, 14th day after scald, with 8 rats at each time point. Expression of Ia antigen on monocyte and lymphocyte apoptosis rate were determined by direct immunofluorescence on a flow cytometer, and TNF-α and IL-6 was measured by ELISA. Results Expression of la on monocyte was obviously lower than that of controls. The lowest levels were recorded on the 6th hours and 1st day after scald. Subsequently, Ia was elevated gradually, but still lower than that of normal rats(P <0. 01). After administration of carbachol, Ia expression was obviously promoted, compared with the simple scald group (P <0. 01). Lymphocyte apoptosis rate, TNF-α and IL-6 was higher than that of controls(P <0. 01). After administration of cavachol, , lymphocyte apoptosis rate and TNF-α and IL-6 was obviously down-regulated on the 6th hours, 1st day, 2nd day and 3rd day after scald injury, compared with the simple scald group (P < 0. 01 or 0. 05). Conclusion After severe burn with delayed fluid resuscitation, there is a low la expression, high lymphocyte apoptosis rate and increased releasing of proinflammatory cytokine. Immune function was suppressed. Carbacho] could improve the immune function of scald rats with delayed fluid resuscitation.     

液体咸蛋清的流变性质及其在工程设计中的应用

用旋转粘度计研究了液体咸蛋清在温度５～４５℃范围内，剪切速率在１７３～２７７０ｓ－１范围内的流变行为。推导出相应剪切应力作为剪切速率函数的幂律模型，并导出流变参数Ｋ和ｎ．参数Ｋ和ｎ是温度的函数。     

《内经》论"咸"

咸为五味之一,<内经>关于咸的理论以咸味入水脏肾为依据,以五行生克乘侮规律为线索,阐述了饮食和药物的咸味与肾,与心(血),与脾胃(津液)的利害关系,主要有下列四个观点.     

"盲""矇""瞽""(目咸)""瞍""瞎"等疾病词考

"瞽"指有眼皮但是没有眼球,眼皮闭合平平如鼓皮而看不见,得名于"鼓";"矇"指眼睛没有任何异常,瞳仁为翳膜所覆盖而看不清楚,得名于"冡"所包含的"因有所遮盖而不明"的特征义;"瞍"指没有眼球而看不见,得名于"叟"所包含的"损坏、破坏"的特征义;"盲"指没有黑睛而看不见,得名于"亡"所包含的"没有"的特征义,后又引申泛指眼睛看不见,为眼睛看不见之统称;"(目咸)"指眼睛凹陷(目曷),"瞎"本作",指黑睛枯陷导致眼睑黏合而看不见,得名于"曷"所包含的"败坏"和"竭尽"的特征义.六者本义有别,但后世渐不加以区分,均用于泛指眼睛失明.