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61.
L. Kalinauskiene D. Cekuoliene M. H. Van IJzendoorn † M. J. Bakermans-Kranenburg † F. Juffer† I. Kusakovskaja 《Child: care, health and development》2009,35(5):613-623
Objective This randomized control trial examined the effects of a short-term, interaction-focused and attachment-based video-feedback intervention (VIPP: video-feedback intervention to promote positive parenting).
Design VIPP effect on mothers' sensitive responsiveness and infant–mother attachment security was evaluated in a sample ( n = 54) of low sensitive, non-clinical, middle class Lithuanian mothers.
Methods Maternal sensitivity was assessed in a free play session with the Ainsworth's sensitivity scale, and attachment security was observed using the Attachment Q sort for home observations.
Results We found that the intervention mothers indeed significantly improved their sensitive responsiveness through participation in our VIPP. The effect size was large according to Cohen's criteria, d = 0.78. VIPP enhanced maternal sensitive responsiveness even when maternal age, educational level, depression, daily hassles, efficacy, infant gender, and infant negative and positive affect were controlled for. However, attachment security in the VIPP infants was not enhanced after the intervention, compared with the control infants, and the infants did not seem to be differentially susceptible to the increase in maternal sensitivity dependent on their temperamental reactivity.
Conclusion We suggest that a relatively brief and low-cost programme can provide effective support for mothers who lack sensitivity in the interactions with their infants. 相似文献
Design VIPP effect on mothers' sensitive responsiveness and infant–mother attachment security was evaluated in a sample ( n = 54) of low sensitive, non-clinical, middle class Lithuanian mothers.
Methods Maternal sensitivity was assessed in a free play session with the Ainsworth's sensitivity scale, and attachment security was observed using the Attachment Q sort for home observations.
Results We found that the intervention mothers indeed significantly improved their sensitive responsiveness through participation in our VIPP. The effect size was large according to Cohen's criteria, d = 0.78. VIPP enhanced maternal sensitive responsiveness even when maternal age, educational level, depression, daily hassles, efficacy, infant gender, and infant negative and positive affect were controlled for. However, attachment security in the VIPP infants was not enhanced after the intervention, compared with the control infants, and the infants did not seem to be differentially susceptible to the increase in maternal sensitivity dependent on their temperamental reactivity.
Conclusion We suggest that a relatively brief and low-cost programme can provide effective support for mothers who lack sensitivity in the interactions with their infants. 相似文献
62.
仓龙卿 《东南大学学报(医学版)》1993,(2)
分析了92例胸膜活检资料,认为其阳性率与下述因素有关:疾病种类、病例选择、活检器械、取材方法及技术、重复检查、临床医师与病理医师的配合。 相似文献
63.
阻塞性睡眠呼吸暂停综合征的临床研究 总被引:4,自引:0,他引:4
强调对阻塞性睡眠呼吸暂停综合征的认识,以达到对该病的早期诊与治疗。方法应用Autoset诊疗系统及鼻持续正压通气治疗仪,对66例OSAS患者进行确诊及序贯治疗。 相似文献
64.
大鼠第三脑室一氧化氮合酶阳性触液神经元的观察 总被引:1,自引:0,他引:1
应用NADPH-d组织化学方法研究脑室系统的一氧化氮合酶(NOS)阳性触液神经元。结果发现,NOS阳性触液神经元主要见于第三脑室。根据胞体所在位置,第三脑室NOS阳性触液神经元可有3种形式:(1)室管膜内触液神经元;(2)室管膜下或远位触液神经元,其突起伸入第三脑室室管膜上皮之间,这些NOS阳性触液神经元有的来自室旁核或室周核;(3)室管膜上触液神经元,其胞体位于室管膜表面。本文首次报道了第三脑室NOS阳性触液神经元,这种触液神经元的分布类型基本和其他递质触液神经元相类同,并讨论了NOS阳性触液神经元的功能。 相似文献
65.
G Wilms C Van Ongeval A L Baert A Claus J Bollen H De Cuyper M Eneman M Malfroid J Peuskens S Heylen 《Acta psychiatrica Scandinavica》1992,85(4):306-312
The ventricle-brain ratio (VBR) of 42 chronic schizophrenic patients was compared with that of 42 age-matched medical controls. For the schizophrenics, the relationship of various clinical parameters to the VBR was assessed, and the outcome of 12 weeks of double-blind treatment with either risperidone or haloperidol. The results confirm that schizophrenic patients have slightly enlarged lateral ventricles compared with medical controls. Only for schizophrenics, an effect of age, but not of duration of illness, was noticed. This study does not support the validity of a clinical subdivision of chronic schizophrenic patients on the basis of the VBR. Neither negative, positive nor general psychopathological symptoms, as measured by the Positive and Negative Syndrome Scale for Schizophrenia (PANSS), were related to the VBR, nor were abnormal involuntary movements or extrapyramidal symptoms. No association between season of birth or a family history of major mental disorder and VBR could be demonstrated. Treatment response was predicted by the total PANSS score and the PANSS general psychopathology subscale score at baseline. There was a trend for patients with higher VBR to have a more or haloperidol). or haloperidol). 相似文献
66.
贯众提取液对革兰氏阳性球菌的抑菌作用 总被引:6,自引:0,他引:6
目的:了解贯众(Dryopteris crossirhizomz)不同提取液对革兰氏阳性球菌的抑菌作用。方法:分别用水以及3种不同pH值的70%乙醇为溶媒提取贯众干品以制备贯众提取液,利用打孔法和试管稀释法测定提取液对13种微生物的抑制效果。结果:每1ml含生药1g的贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用,尤其是革兰氏阳性球菌如金黄色葡萄球菌和甲型溶血性链球菌等。对革兰氏阴性菌和真菌的抑制作用较弱,但对普通变形杆菌则有较强的抑制作用。不同pH值的抽提溶剂对药物的有效抑菌成份的提出效果不同,抽提溶剂pH越小,有效成份的提出效果越好。结论:贯众醇提液、水提液对革兰氏阳性菌有较强的抑制作用,尤其是对革兰氏阳性球菌,而对革兰氏阴性菌和真菌的抑制作用则较弱。贯众的抗菌成份易溶于水,抽提效果随pH减小而增加。 相似文献
67.
Twenty-two women were studied during laparoscopy with abdominal insufflation of carbon dioxide. A bain anaesthetic breathing circuit was used with a fresh gas flow (VFG) of 110 ml.min-1.kg-1, and controlled ventilation was applied with a minute ventilation (VE) of 175 ml.min-1.kg-1. Arterial blood gases were analysed at the end of the operation. Nineteen of the women (86 per cent) were found to have a PaCO2 within the range for normocapnia (i.e., 4.7-5.9 kPa (35-45 mmHg), two were hypocapnic with a PaCO2 of 4.4 and 4.5 kPa (33 and 34 mmHg) respectively and one was found to have a PaCO2 of 6.2 kPa (46.5 mmHg). It was concluded that the carbon dioxide absorbed from the abdomen during laparoscopy demands fresh gas flows that are higher than normally used in the Bain circuit if a PaCO2 within the normal range is to be obtained. A simultaneous increase in VFG and VE of about 45 per cent is sufficient to achieve normocapnia. 相似文献
68.
Mireille Lahoud David Vremec Richard L. Boyd Ken Shortman 《Clinical & developmental immunology》1993,3(2):103-112
Thymic nurse cells (TNC), multicellular complexes consisting of lymphoid cells
enclosed within cortical epithelial cells, were isolated from mouse thymus by a modified
procedure allowing immunofluorescent labeling and flow cytometric analysis of their
lymphoid contents (TNC-L). Collagenase was the only protease used for tissue
digestion, to ensure that surface antigen markers remained intact. Zonal unit-gravity
elutriation was used to enrich the TNC on the basis of their high sedimentation rate,
followed by immunomagnetic bead depletion to remove residual mononuclear cell
contaminants and a density separation to remove debris. The TNC-L were then released
from inside TNC by a short period of culture. The measured contamination of TNC-L
with exogenous thymocytes was around 0.5%. Three-color immunofluorescent labeling
revealed that TNC-L included, as well as a maiority of immature CD4+8+3low thymocytes,
about 12% of apparently mature CD4+8-3high and CD4-8+3high thymocytes. TNC are
located in the cortex, where mature cells are rare; the occurrence of mature phenotype
cells within these structures suggests that they represent a microenvironment for the
selection and generation of mature T cells. 相似文献
69.
Alan Ma Sunita Gurnasinghani Edwin P. Kirk Conor McClenaghan Gautam K. Singh Dorothy K. Grange Chetan Pandit Yung Zhu Tony Roscioli George Elakis Michael Buckley Bhavesh Mehta Philip Roberts Jonathan Mervis Andrew Biggin Colin G. Nichols 《American journal of medical genetics. Part A》2019,179(8):1585-1590
Cantú syndrome (CS), characterized by hypertrichosis, distinctive facial features, and complex cardiovascular abnormalities, is caused by pathogenic variants in ABCC9 and KCNJ8 genes. These genes encode gain‐of‐function mutations in the regulatory (SUR2) and pore‐forming (Kir6.1) subunits of KATP channels, respectively, suggesting that channel‐blocking sulfonylureas could be a viable therapy. Here we report a neonate with CS, carrying a heterozygous ABCC9 variant (c.3347G>A, p.Arg1116His), born prematurely at 32 weeks gestation. Initial echocardiogram revealed a large patent ductus arteriosus (PDA), and high pulmonary pressures with enlarged right ventricle. He initially received surfactant and continuous positive airway pressure ventilation and was invasively ventilated for 4 weeks, until PDA ligation. After surgery, he still had ongoing bilevel positive airway pressure (BiPAP) requirement, but was subsequently weaned to nocturnal BiPAP. He was treated for pulmonary hypertension with Sildenafil, but failed to make further clinical improvement. A therapeutic glibenclamide trial was commenced in week 11 (initial dose of 0.05 mg–1 kg–1 day–1 in two divided doses). After 1 week of treatment, he began to tolerate time off BiPAP when awake, and edema improved. Glibenclamide was well tolerated, and the dose was slowly increased to 0.15 mg?1 kg?1day?1 over the next 12 weeks. Mild transient hypoglycemia was observed, but there was no cardiovascular dysfunction. Confirmation of therapeutic benefit will require studies of more CS patients but, based on this limited experience, consideration should be given to glibenclamide as CS therapy, although problems associated with prematurity, and complications of hypoglycemia, might limit outcome in critically ill neonates with CS. 相似文献
70.
C Penit 《International immunology》1990,2(7):629-638
T cell antigen receptor expression by cycling and post-cycling thymocytes has been analysed by flow cytometry. Normal mice were pulsed with 5-bromo-2'-deoxyuridine (BrdUrd), a thymidine analogue detectable with a monoclonal antibody. Thymocytes were surface-stained with antibodies against several V beta gene products and against whole alpha beta receptors and detection of BrdUrd in the nuclei was performed after enzymatic generation of single-stranded DNA. A significant (10%) percentage of thymocytes expressing high levels of alpha beta TCR were found in the cycle: these cells were immature, as shown by the CD4+8+ phenotype and by high HSA expression. After division, most alpha beta high BrdUrd+ cells entered a resting state and their number remained constant for 3 days, decreasing in two steps thereafter. This post-mitotic evolution was not modified by injection of an anti-mitotic drug. After day 4, a majority of the studied subset acquired a single positive phenotype. Location of BrdUrd+ V beta 8.2 high cells studied on frozen sections was found cortical at early times and medullary after day 3. V beta 6 expression by cycling and post-cycling thymocytes was analysed in various mouse strains, and early high expression by cycling thymocytes was found to be restricted to MIs 1b strains. These results suggest that high alpha beta TCR expression by cycling immature thymocytes corresponds to positive selection, which must therefore be considered as an early event in intrathymic differentiation. 相似文献