Reverse engineering techniques applied to a human skull,for CAD 3D reconstruction and physical replication by rapid prototyping

The production of a copy of an existing object of complex shape is one of the typical applications of the integration between two modern computer-based technologies, reverse engineering (RE) and rapid prototyping (RP). The method is extremely versatile and can be used in various applicative domains (e.g. replacement of anatomical parts with artificial prostheses, replication of skeletal remains). Two different acquisition techniques of images of a skull, by laser and by CT scan, were compared to ascertain which enabled more accurate reproduction of the original specimen. The skull was chosen due to it being the body part most often used in medico-legal investigations (for personal identification, skull-photo superimposition techniques, forensic art, etc). Comparison between the copy and the original yielded satisfactory results for both techniques. However, CT scanning demonstrated some advantages over the laser technique, as it provided a cleaner point cloud, enabling shorter pre-reproduction processing times, as well as data on the internal parts, which resulted in the reproduction of a more faithful copy.     

Formulation and optimization of potassium iodide tablets

The use of potassium iodide (KI) as a protective agent against accidental radioactive exposure is well established. In this study, we aimed to prepare a KI tablet formulation using a direct compression method. We utilized Design of Experiment (DoE)/mixture design to define the best formulation with predetermined physical qualities as to its dissolution, hardness, assay, disintegration, and angle of repose. Based on the results from the DoE, the formulation had the following components (%w/w): Avicel 48.70%, silicon dioxide 0.27%, stearic acid (1.00%), magnesium stearate 2.45%, and dicalcium phosphate 18.69%, in addition to potassium iodide 28.89% (130 mg/tablet). This formulation was scaled-up using two tablet presses, a single-punch press and a rotary mini tablet press. The final scaled-up formulation was subjected to a variety of quality control tests, including photo-stability testing. The results indicate that potassium iodide tablets prepared by a rotary mini tablet press had good pharmaceutical characteristics and a shelf-life of 25 days when stored at room temperature protected from light.     

医用电子直线加速器的技术应用与研究

目的：分析研究医用电子直线加速器的设计原理，定性、定量地解析研究加速器的技术关键，深入探索加速器的核心细节。方法：应用总分类的逻辑思路，从国内肿瘤情势的分布、行业的需求及放射治疗设备本身的技术发展，研究分析医用加速器的工作原理、技术应用、设计细节。结果：医用电子加速器电子的获得、微波加速及内部环境支撑，其核心是微波类型的应用，而且加速管的结构至关重要。结论：驻波电子直线加速器较行波电子直线加速器的发展晚，是由于稳定的加速电子结构和技术不成熟所致。巧妙的新型边耦合加速结构，为加速器的研究提供了技术支持与保障。     

基于持续改进的医院质量管理组织设计:以浙江省为例

针对浙江省三级综合性医院质量管理组织设置现状,结合JCI、六西格玛、ISO9000、卓越绩效模式、QC小组等质量管理组织建设经验,根据医院质量管理活动的不同特性,提出了基于持续改进的质量管理组织设计模型。指出:控制型质量活动依托常规的三级质控体系,从高层领导、质量专职部门、科室层面的质量管理3方面,强化了原有质量组织的职能与作用;创造型质量活动则借助跨职能团队的运作,到达持续质量改进的目的。     

民族医学网络课程的设计与应用实践

本文从民族医学网络课程的开发设计的背景和意义出发,分析了该网络课程在开发过程中的教学设计思想及模块建设,探讨了该网络课程的设计制作经验和建设体会.实践证明,民族医学网络课程教学效果明显、成绩显著.     

临床洗胃进出液平衡监测系统的开发与应用

利用电磁流量测量技术和计算机技术,自主设计了一种洗胃进出液平衡监测系统,以满足临床急诊中毒洗胃需要,实现液体量的精密监测。该系统能持续监测洗胃进出液量,并对出现的异常数值及时报警,系统操作方便,监测指标灵敏可靠,能满足急诊抢救需要。     

均匀设计优选金茵清热口服液半仿生提取的工艺条件

目的:优选金茵清热口服液半仿生提取的工艺条件。方法:采用均匀设计,以绿原酸得率,栀子苷得率,总酚酸得率和干浸膏收率为指标进行综合评价,优选金茵清热口服液半仿生提取的工艺条件。结果:优选的三煎用水pH依次为A=2.89,B=6.50,C=8.43;煎煮总时间D=2.0 h。结论:结合生产实际,确定3煎用水的pH依次为3.0,6.5,8.5;煎煮时间依次为1.0,0.5,0.5 h。     

新型抗EV71病毒3C蛋白酶抑制药的设计、合成及其活性

摘 要 目的： 寻找抗EV71病毒新化合物。方法: 采用分子模拟技术,以EV71病毒3C蛋白酶活性口袋为靶,设计二肽、三肽,四肽,五肽和六肽等多个系列寡肽化合物,合成对接评分较高的寡肽化合物并进行抗EV71病毒活性筛选。结果: 五肽对接评分高于其他系列寡肽,显示五肽化合物与EV71 病毒3C蛋白酶有更强的键合力。研究中合成了两个评分较高的五肽化合物25和化合物16,体外抗EV71病毒活性实验显示化合物25活性较强（EC₅₀=1.36 μmol·L^-1,CC₅₀=211.94 μmol·L^-1, SI=155.84）,而化合物16则无明显活性。结论:五肽化合物25可作为抗EV71病毒新骨架开展进一步研究。