Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice

This paper describes the success and expansion of ovarian tissue cryopreservation and transplantation as a fertility restoration procedure, with the largest series of 60 live births worldwide reported. By repeating the procedure, ovarian activity can be restored for more than 11 years.     

从脾胃论治失眠探析

失眠病因病机复杂,皆与五脏六腑有关。《黄帝内经》言"胃不和则卧不安",概括了胃不和导致不寐的病理机制。内伤脾胃,百病始生。若忧思劳倦过度伤脾,脾胃亏虚,运化失调,精微化生无源,气血虚衰,意不入舍,心失所养或宿食痰火内停,胃失和降,浊邪上扰均可导致阴不涵阳,阳不入阴,心神不安,从而导致不寐。笔者通过探讨脾胃与失眠的关系,明晰从脾胃论治失眠的机制,进而更好地指导临床治疗用药。     

The effect of cancer on reproductive health

The incidence of cancer and survival rates are increasing, as is the consequent impact on reproductive health. Delay in childbearing years is also an important factor. It is well documented that a significant number of cancer treatments are gonadotoxic. This can lead to fertility concerns and long term effects for both men and women. Fertility preservation should only take place if the patient is well enough, where there is time and if it will not worsen their oncological condition. In men, fertility preservation is a straightforward procedure, whereas in women it is more invasive, carries more risk and can significantly delay cancer treatment. The long term effects of cancer treatment include early menopause, erectile dysfunction, loss of libido and psychosexual dysfunction. These factors can significantly affect quality of life. Hence, well organised referral pathways and counselling services are paramount and must include a multidisciplinary approach involving relevant specialists.     

22例附件扭转保留卵巢手术的临床经验分析

目的探讨附件扭转患者保留卵巢手术的安全性和可行性。方法回顾性分析于我院经手术确诊附件扭转行保留卵巢手术的22例患者的临床资料,并分析手术方案及预后情况。结果患者均成功实施了保留卵巢手术,术后无盆腔炎、肺栓塞等并发症发生;20例患者行腹腔镜手术,2例患者行开腹手术;平均扭转度数(523.64°±235.08°);平均出血量(17.50±11.21)mL;成熟畸胎瘤占多数,占比31.8%(7/22);合并早期妊娠2例,其中1例行开腹卵巢保留手术,现已足月顺娩,另1例行腹腔镜下卵巢保留术+人工流产术,术后40 d月经恢复正常;18例非妊娠患者术后12个月复诊,月经量及经期、周期与术前无明显变化,1例术后第2年足月妊娠剖宫产1女婴;2例月经前期女性,术后1~1.5年月经来潮,且月经正常;术后盆腔超声见患侧卵巢大小正常,有小卵泡或优势卵泡发育。结论附件扭转行保留卵巢手术,具有一定的安全性和可行性,最大程度地保留了年轻女性的内分泌及潜在生殖功能。     

基于免疫机制从“脾虚生痰湿”论治多发性抽动症的研究＊

多发性抽动症的发病率逐年升高，严重影响儿童生长发育及心理健康。中医治疗多发性抽动症（脾虚痰湿型）取得显著效果，但作用机制仍不明确。近年来，诸多研究表明“脾虚生痰湿”和免疫系统之间存在密切关系，还揭示了免疫机制在抽动症发病中起重要作用。本文通过概述多发性抽动症（脾虚痰湿型）的病机与免疫之间的关系，发现多发性抽动症（脾虚痰湿型）患者免疫状态与大脑皮质-基底节-丘脑-皮层回路异常密切相关，细胞免疫损伤参与了多发性抽动症的发生和发展。并分析了健脾化痰祛湿中药治疗多发性抽动症的潜在机制，为从“脾虚生痰湿”论治多发性抽动症提供相关科学依据。     

Skin graft storage in platelet rich plasma (PRP)

Storage of skin grafts for later use is one of the standard applications in surgery. It is the most preferred method to maintain at +4°C in refrigeration after wrapping the surplus grafts into sterile gauze pad moistened with saline. Although there are many studies on the storage of skin grafts, less is known about storing skin grafts with PRP. Twenty‐five pieces of 1 × 1 cm² partial thickness skin graft were harvested from 12 patients during the reduction mammoplasty operation. Twenty‐four grafts were divided into 4 groups, and each group consisted of 6 grafts, 1 graft was analyzed as Day 0. Grafts in Group 1, 2, and 3 were wrapped by sterile gauze pad moistened by either saline (Group 1) or Hartman (Group 2) or PRP (Group 3). Grafts were analyzed macroscopically and microscopically. There were no significant differences between media for the first 10 days. Decrease in viability was less in saline and PRP wrapped grafts at 20 day, viability decreased significantly in all environments after 20 days. Although there was no significant difference in saline or PRP storage, it was observed macroscopically that the grafts stored in the PRP appeared better.     

Use of Fertility Preservation Among a Cohort of Transgirls in the Netherlands

Purpose

The primary aims of the study are to examine the rate of attempted fertility preservation (FP) among a Dutch cohort of transgirls who started gonadotropin-releasing hormone analog treatment and the reasons why adolescents did or did not choose to attempt FP.