2种奥美拉唑胶囊的人体药动学参数比较

目的 :比较 2种奥美拉唑胶囊在健康志愿者体内的药动学参数。方法 :10对 (2 0名 )健康志愿者随机口服 2种奥美拉唑胶囊各 2粒 (每粒 2 0mg) ,1wk后再交叉服药。用RP HPLC法测定奥美拉唑在体内的血药浓度。用 3P97软件处理 2种胶囊制剂的药动学参数。结果 :奥美拉唑的药 时曲线符合单室模型。奥美拉唑胶囊口服给药 4 0mg后 ,经方差分析显示 2种胶囊的主要药动学参数差异无显著意义 (P >0 .0 5 )。 2种胶囊的相对生物利用度为 (95 .5～ 110 .7) %。结论 :2种奥美拉唑胶囊制剂具有生物等效性     

舒咽灵软胶囊的抗炎、抗菌和免疫调节作用

目的：研究舒咽灵软胶囊的抗炎、抗菌和免疫调节作用，为其临床应用提供药效学基础。方法：采用小鼠耳片肿胀法和大鼠松节油气囊肉芽增生法，观察舒咽灵软胶囊的抗炎作用；通过体内、体外抗菌试验，观察抗菌作用。此外，通过观察对小鼠脾淋巴细胞增殖反应的影响，对小鼠抗体形成细胞的影响，以及对白细胞吞噬功能的影响，确定其免疫调理作用。结果：在体外，舒咽灵软胶囊对16种细菌均有程度不同的抑菌作用及杀菌作用，且该药对球菌作用优于杆菌；在体内，对金葡菌及伤寒杆菌感染的小鼠均具有保护作用；还能程度不同地增强小鼠的中性粒细胞吞噬功能、促进脾脏抗体形成细胞活性及促进小鼠脾T细胞及B细胞的转化能力；对小鼠及大鼠急慢性炎症均有抑制作用。结论：舒咽灵软胶囊具有抗炎、抗菌及免疫调节作用。     

六味木香胶囊西咪替丁治疗反流性食管炎

目的：观察六味木香胶囊与西咪替丁联用治疗反流性食管炎的临床疗效。方法：将104例内镜诊断反流性食管炎患者随机分为两组，治疗组56例，六味木香胶囊5粒，每日2次，西咪替丁800mg，每晚睡前1次，口服；对照组48例，单服同剂量西咪替丁，疗程均为4周。结果：两组症状控制总有效率分别为96．3％和54．1％(P＜0．01)，内镜改善总有效率分别为94％和60％(P＜0．05)。结论：六味木香胶囊与西咪替丁联用是治疗反流性食管炎的理想方案。     

Extended wear disposable soft contact lenses as an alternative to photorefractive keratectomy: Report of 4 years experience

Purpose: To establish whether; in a well-informed population, the use of extended wear disposable soft contact lenses (EWDSCL) poses an unacceptable risk to vision and corneal health due to complications associated with their use. Methods: A 4 year retrospective review of EWDSCL, involving 371 patients in Melbourne from a single general ophthalmology practice. The important aspects of this group were that all patients were given written instructions about the methods of ensuring initial and ongoing cleanliness of lenses, no lenses were cleaned and reinserted, and no solutions other than the saline in the original packaging, and comfort drops, were used. Two types of EWDSCL were used, in powers from - 9.0 to + 6.0 D, and with an initial aim of 4 weeks uninterrupted extended wear. Follow-up was from 2 to 52 months, with an average of 24 months. Results: Of the 354 patients followed up, 236 (66%) regularly wore them on an extended overnight basis, and of these 180 (76%) wore them for the suggested 4 week period before renewal of lenses. In the 471 eyes of 236 patients, adverse reactions occurred at the following rates: marginal infiltrates (12 cases, 2.5%); corneal oedema (10 cases, 2%); peripheral corneal vascularization (2 cases, 0.4%); and presumed infective keratitis (1 case, 0.2%). No eyes lost one or more lines of Snellen acuity. Conclusions: When disposable soft contact lenses do not come into contact with cleaning solutions, saline from bottles or aerosol cans, or storage cases, their use on an extended wear basis (up to 4 weeks continuous) appears to be associated with a low risk of minor or major complications. The results of this review indicate that controlled usage of EWDSCL is safer than previous reports have indicated.     

Spindle cell lipoma—a pseudoangiomatous variant

Five cases of an unusual pseudoangiomatous variant of spindle cell lipoma are presented. In keeping with more typical cases, these lesions occurred principally in the shoulder and neck regions of adult males. The lesions all had the features of typical spindle cell lipoma but, in addition, exhibited irregular and branching spaces with villiform connective tissue projections, giving a striking angiomatoid appearance. Although the pathogenesis is uncertain, this unusual histological pattern seems to be the result of myxoid degeneration and may lead to a mistaken diagnosis of a true vascular tumour or other non-lipomatous spindle cell lesion.     

应用复合组织瓣再造软腭

用全腭粘骨膜瓣加咽后壁复合组织瓣再造软腭。用此手术方法修复鳞癌切除所致软腭缺损４例，腭粘骨膜瓣面积为５ｃｍ×４．５ｃｍ～５．５ｃｍ×５ｃｍ，咽后壁瓣长５ｃｍ，宽２．５ｃｍ，４例切口均Ⅰ期愈合，形态及功能恢复良好。     

软式内镜清洗消毒保养体会

内镜设备和器械对于目前日新月异的微创技术来说有着举足轻重的作用,是开展内镜手术必需的工具.随着内镜器械的频繁使用,由内镜诊疗引起的医院感染的危险性大大增加.本文正式基于此,以软式内镜清洗消毒保养的相关注意事项为研究对象,通过对相关问题的阐述,提出了有效清洗消毒保养软式内镜的措施,旨在为相关操作实践提供指导和帮助.     

Myointimoma of the glans penis

Myointimoma is a recently described benign tumor, which is regarded as a rare type of mesenchymal tumor of the penis. The present patient was a 50-year-old man who had a nodule located in the glans penis. He had a 2 month history of a mass. An excisional biopsy was performed. The histological findings revealed a multinodular tumor that was characterized by spindle-shaped cells located in the intravascular area. This case, in addition to 11 cases reported in the literature, demonstrates that the myointimoma is frequently misdiagnosed on clinical and pathological grounds because of its rarity. Histological and immunohistochemical features are summarized on the basis of the present case and previously published reports.     

African swine fever virus DNA in soft ticks, Senegal

African swine fever is a highly contagious disease of pigs in Africa. Although its persistence in Senegal may be caused by asymptomatic carriers involved in the domestic transmission cycle, we demonstrated that the soft tick Ornithodoros sonrai can be naturally infected with the causative agent.     

软组织肉瘤化疗耐药机制及治疗的研究进展

骨与软组织肿瘤发病率低,属于罕见肿瘤范畴,目前化疗仍是骨与软组织肉瘤有效的治疗方法,但化疗耐药的存在严重影响了患者的近期疗效、远期生存,本文对软组织肉瘤化疗耐药机制及相应的治疗进展作一综述。