一阶导数光谱法测定盐酸丁卡因滴眼液的含量

采用一阶导数光谱测定盐酸丁卡因滴眼液含量，取其导数光谱特征振幅作为定量信息，并可涓除对羟基苯甲酸乙酯的干扰，操作简便。相关系数r＝0．9997，回收率99．55％（RSD＝0．38％）     

A New Ternary Polymeric Matrix System for Controlled Drug Delivery of Highly Soluble Drugs: I. Diltiazem Hydrochloride

Purpose. The purpose of this study was to develop a new ternary polymeric matrix system that is easy to manufacture and that delivers a highly soluble drug over long periods of time. Methods. Pectin, hydroxypropylmethylcellulose (HPMC), and diltiazem HC1 granulated with gelatin at optimized ratios were blended at different loading doses and directly compressed. Swelling behavior, dissolution profiles and the effect of hydrodynamic stress on release kinetics were evaluated. Results. Diltiazem release kinetics from the ternary polymeric system was dependent on the different swelling behavior of the polymers and varied with the drug loading dose and hydrodynamic conditions. Drug release followed either non-Fickian or Case II transport kinetics. The relative influence of diffusion and relaxational/dissolution effects on release profiles for different drug loadings was calculated by a nonlinear regression approach. Photographs taken during swelling show that the anisotropic nature of the gel structure, drug loading dose, swelling capacity of polymers used, and the design of delivery system all play important roles in controlling the drug release and dissolution/ erosion processes. Conclusions. Zero-order delivery of diltiazem HC1 from a simple tablet matrix was achieved. The ternary polymeric system developed in this study is suitable for controlled release of highly soluble drugs. It offers a number of advantages over existing systems, including ease of manufacturing and of release modulation, as well as reproducibility of release profiles under well defined hydrodynamic conditions. Our delivery system has the potential to fully release its drug content in a controlled manner over a long time period and to dissolve completely.     

盐酸哌唑嗪对家兔地高辛血药浓度的影响

目的观察盐酸哌唑嗪对单剂量给药的地高辛血药浓度或多次给药的地高辛稳态血药浓度的影响 ,为临床合理用药提供实验依据。方法给家兔灌胃地高辛20μg/kg,盐酸哌唑嗪150μg/kg,于家兔耳缘静脉定时采血 ,应用荧光偏振免疫法测定地高辛血药浓度 ,比较应用盐酸哌唑嗪前后地高辛血药浓度。结果单次给地高辛时 ,盐酸哌唑嗪可延长地高辛的吸收和消除过程 ;多次服用地高辛时 ,在合用盐酸哌唑嗪6h后 ,地高辛的稳态血药浓度显著提高。结论临床合用地高辛和盐酸哌唑嗪时应严格个体化给药 ,密切监测地高辛血药浓度     

盐酸瑞芬太尼在无痛肠镜检查及治疗中的应用

无痛肠镜检查及治疗术中静脉注射国产盐酸瑞芬太尼能即时产生良好的镇痛效果,术后苏醒快。国产盐酸瑞芬太尼与进口雷米芬太尼的临床疗效差异无显著意义。     

盐酸小檗碱对心脏移植受者环孢素A血浓度的影响

目的观察联合应用盐酸小檗碱（黄连素，berberin hydrochloride，Ber）对心脏移植受者环孢素A（cyclosporineA，CsA）血浓度的影响。方法观察22例服用CsA心脏移植受者联合服用Ber后CsA全血浓度，肝、肾功能和血脂变化。结果合用Ber后CsA全血稳态C0和C2浓度与合用前比较明显增加（P〈0．01），平均浓度分别增加26％和18％；21例服用CsA剂量减少25～100mg／d，Ber与CsA合用对受者的肝、肾功能及血脂无明显影响（P〉0．05）。结论合用Ber能升高心脏移植受者CsA血浓度，减少CsA服用剂量，节省费用，且无明显不良反应。     

吸毒者尿液中吗啡的现场薄层检测法（第二报）

本文在第一报的基础上，对实验条件，方法的灵敏度和２９种有关药物及空水对方法的干扰情况进行了系统考察；同时与ＧＣ－ＭＳ和试剂盒进行了方法比较；吗啡衍生物（ＲＳＯ２－Ｍ）进行结构分析，临床验证２４７例。方法灵敏度为１０ｎｇ（板上）ＳＩ展开剂的平均Ｒｆ值为０．２９，ＳＤ为０．０２４，ＳⅡ展开剂的平均Ｒｆ值为０．３８，ＳＤ为０．０７２；酸水解的最佳条件为１００℃，加热３０分钟，衍生化的最佳条件为ｐＨ８－９     

盐酸多塞平乳膏与盐酸赛庚啶乳膏对照治疗慢性神经性皮炎75例

目的:评价盐酸多塞平乳膏治疗慢性神经性皮炎的疗效.方法:75例慢性神经性皮炎患者,随机分为治疗组(n=30,用盐酸多塞平乳膏)、阴性对照组(n=30,用凡士林、甘油等制备的基质乳膏)和阳性对照组(n=15,用盐酸赛庚啶乳膏),局部外用,tid,每次使用面积不超过全身的8%,8d为1个疗程.结果:治疗组治疗后瘙痒和皮疹面积总平均下降分多于阳性对照组及阴性对照组,统计学处理差异均有显著性.盐酸多塞平乳膏止痒作用突出,而皮损消退作用则相对缓慢,不良反应小.结论:盐酸多塞平乳膏治疗慢性神经性皮炎安全有效.     

盐酸金刚乙胺颗粒人体生物等效性研究

 目的用高效液相色谱-质谱法(LC-MS)测定受试者口服盐酸金刚乙胺制剂后的血药浓度,估算受试制剂和参比制剂的药动学参数,评价两种制剂的生物等效性和相对生物利用度。方法采用随机二交叉设计试验,20例男性健康志愿受试者,单剂量口服受试制剂盐酸金刚乙胺颗粒和参比制剂盐酸金刚乙胺片。以LC-MS测定血浆中金刚乙胺的浓度。采用BAPP3.0软件处理计算主要药动学参数。结果受试制剂和参比制剂血浆中金刚乙胺的t_1/2分别为(26.46±4.48)和(27.41±4.42)h;ρ_max分别为(84.5±17.7)和(93.1±17.8)μg·L^-1;t_max分别为(4.08±2.86)和(4.70±3.59)h;AUC_0-120h分别为(3204±691)和(3450±724)μg·h·L^-1;AUC_0-∞分别为(3395±767)和(3661±820)μg·h·L^-1;人体相对生物利用度为(93.4±10.8)%。结论2种制剂在健康人体内具有生物等效性。