绝经后子宫内膜癌患者彩超检验结果分析

目的:综合分析彩超判断子宫内膜厚度在绝经后妇女子宫内膜癌中的诊断效果。方法:在2014年8月至2016年8月选取我院收治的120例绝经后阴道出血妇女患者临床资料作为研究对象,其中有30例子宫内膜癌患者(A组)、30例子宫内膜增生患者(B组)、30例子宫内膜炎患者(C组)以及30例正常子宫内膜患者(D组)。分析四组患者的平均子宫内膜厚度、内膜均匀厚度以及血流特征等参数指标。结果:A组患者子宫内膜厚度显著高于B、C、D三组患者(P0.05);A组患者与B、C、D三组患者的内膜均匀程度比较无统计学意义(P0.05);A组患者血流特征≤4的比例显著高于B、C、D三组患者(P0.05)。结论:彩超判断子宫内膜厚度在绝经后妇女子宫内膜癌中的诊断效果比较高。     

绝经后女性外周骨超声速率与PINP的相关性研究

目的 观察绝经后女性指骨、桡骨、胫骨超声速率(SOS)随年龄变化的规律及其与骨代谢指标血清Ⅰ型前胶原氨基端前肽(PINP)、骨钙素(BGP)和甲状旁腺激素(PTH)的关系.方法 入选绝经后女性84例(42～85岁),其骨代谢生化指标血清PINP和PTH采用酶联免疫法测定,BGP采用放射免疫法测定;应用sunlight omnisense 7000TM型超声骨量测定系统测量研究对象的SOS.结果 绝经后女性桡骨、指骨和胫骨SOS指标值随年龄段递增而下降,但只有桡骨SOS在各年龄段之间差异存在统计学意义(P＜0.05);PINP、BGP和PTH随年龄段递增有变化但(P＞0.05),且与各部位超声骨量SOS的直线相关分析及多元线性回归均无统计学意义.结论 绝经后女性桡骨SOS能够反映绝经后女性骨密度随年龄的衰减,可能是超声骨量测定反映绝经后女性骨量变化的最佳部位.     

绝经后骨质疏松症生存质量的调查研究

目的对约经后骨质疏松症患的生存质量进行调查和评价。方法对４２１名社区绝经后妇女进行腰椎双能Ｘ线扫描测定骨密度,利用ＳＦ－３６生存质量调查量进行了生存质量调查。结果４２１名绝经后妇女中骨质疏松症的发病率为６０％。同时,骨质疏松症患生存质量低于非骨质疏松症患。结论绝经后骨质疏松症患的生存质量与正常人相比下降,生存质量的进一步的研究有可能引入骨质疏松症的诊断与疗产评价。     

EFFECT OF ACUPUNCTURE ON SERUM INTERLUKIN—6 IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS

Objective: To observe the effect of acupuncture on serum interlukin-6 (IL-6) level in women with post-menopausal osteoporosis. Methods: 59 cases of postmenopausal osteoporosis women were randomly divided into acupunctue group(n=32) and calcium D group(n = 27). In acupuncture group, Zusanli (ST 36), Sanyinjiao (SP 6), Shenshu (BL 23) and Pishu (BL 20) were punctured, 3 times every week, continuously for 6 months. In control group, patients were ordered to take Calcium D, one pill (containing 1500 mg calcium carbonate and VitD3) every morning, continuously for 6 months. Serum IL-6 was detected using radioimmunoassay. Results: After six months' treatment, the result showed that in acupuncture group serum IL-6 calcium level lowered while in control group serum IL-6 content increased. Statistical analysis indicates that there are no significant differences between two groups or between pre-treatment and post-treatment in every single group( P > 0.05). Conclusion: Although no statistical difference was found b     

绝经后妇女原发性骨质疏松症中医辨证分型与骨密度的相关性研究

目的:探讨绝经后妇女原发性骨质疏松症中医辨证分型与骨密度的相关性.方法:通过对118例正常绝经后女性T12～L2椎体进行骨密度测量,从中筛选出91例绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)患者.结果:根据中医辨证分型的标准进行辨证分型,发现绝经后女性骨质疏松症中医证型分布规律:肝肾阴虚型43例占47.25%,肾阴虚型15例占16.48%,肾阳虚型10例占10.99%,脾肾阳虚型9例占9.89%,脾胃虚弱型5例占5.49%,其他类型9例占9.89%,通过单因数方差分析,各型骨量减少程度无统计学差异.证候主要特征集中表现为腰膝酸软或疼痛79例占86.81%.结论:初步认为原发性骨质疏松这样一个涉及多脏腑的复杂病变,证型证候有一定规律可循,但其与骨密度之间无显著相关性,可能与样本量较少和受试者职业的多样性等因素有一定关系,尚需在以后研究中做进一步的探讨.     

补肾健脾活血方对去卵巢大鼠骨转换主要生化指标的影响

目的：观察补肾健脾活血方对绝经后骨质疏松症患骨转换主要生化标志物的影响。方法：选用6月龄SD雌性大鼠84只，随机分成正常组，假手术组，模型组，中药对照组，西药对照组，补肾健脾活血方大，小剂量组共7组，用卵巢切除的方法进行物造模，给药90天后检测血清E2、BGP和尿DPD等指标进行观察，结果：补肾健脾活血方能明显增加血清E2，BGP的含量，降低尿DPD含量（P＜0．01），其作用优越于西药雌激素治疗，且与剂量呈正相关。结论：补肾健脾活血方能促进骨形成，降低骨吸收。     

六味地黄丸加味治疗绝经后骨质疏松症疗效观察

应用六味地黄丸加味治疗绝经后骨质疏松症，与口服钙尔奇D、静滴精制骨宁注射液比较，效果显著。     

Comparison of quantitative ultrasound of the phalanges with conventional bone densitometry in healthy postmenopausal women

The objective of this study was to evaluate the utility of the quantitative ultrasound (QUS) technique for the identification of subjects with spine fracture or low bone mineral density (BMD) previously determined by dual energy X-ray absorptiometry (DEXA). QUS of the phalanges in 1,350 postmenopausal women (60–83 years old) was compared with DEXA measurements of four skeletal sites (lumbar spine, total hip, femoral neck, and distal radius) of the same subjects. The contribution of body mass index (BMI) was also assessed. Amplitude dependent speed of sound (AD-SoS), ultrasound bone profile index (UBPI), and BMD of all anatomical regions, except for the spine, decreased significantly with increasing age quartiles. QUS parameters correlated weakly but significantly with BMD ( r =0.21–0.31, p <0.01). After adjustment for BMI, the association between QUS parameters and BMD remained unchanged. UBPI was found to be independent of BMI. All techniques and all sites were able to significantly discriminate fractured from non-fractured subjects by receiver operating characteristic (ROC) analysis (area under the curve [AUC]0.60, p <0.0001). AD-SoS and UBPI showed similar fracture discrimination ability of spine, distal radius and total body BMD in terms of odds ratios, but BMD of the total hip and femoral neck showed the best performance in discriminating fractured from non-fractured subjects. In conclusion, QUS assessment of the phalanges correlates moderately with BMD of all skeletal sites and is able to effectively discriminate fractured from non-fractured subjects.The authors wrote this article on behalf of the PERF study group     

Excess non-spine fractures in women over 50 years with celiac disease: A cross-sectional, questionnaire-based study

The association of celiac disease with fracture is controversial. Recent studies may have underestimated the impact by studying patients with low fracture risk. Since postmenopausal women are at greatest risk of fracture, we have investigated non-spine fracture occurrence in women 50 years with celiac disease. Patients were recruited from hospital and general practice as well as from volunteers, controls from general practice. All completed a questionnaire detailing fracture occurrence. Three hundred and eighty-three female celiac patients and 445 female controls aged 50 years at time of study were compared. Mean age was 61.4±7.8 years in celiac patients and 62.7±9.9 years in controls. Celiac patients were lighter but not shorter. Celiac patients displayed greater all fracture prevalence (odds ratio [OR], 1.51; confidence interval [CI], 1.13:2.02) and fracture after 50 years (OR, 2.20; CI, 1.49:3.25). Wrist fracture was more frequent (OR, 1.65; CI, 1.12:2.41), but significance was lost once height and weight were taken into account. Celiac patients had more multiple fractures (OR, 2.96; CI, 1.81:4.83). To investigate the association of fracture with time from diagnosis, 324 celiac patients were paired with a control by age. No excess fracture risk was found more than 10 years before diagnosis amongst celiac patients diagnosed after age 50 years, but risk increased in the period from 10 years before diagnosis to 5 years after and remained high more than 5 years after diagnosis ( p<0.05). Wrist fracture only increased in the period more than 5 years after diagnosis ( p<0.05). In women diagnosed before 50 years, no excess fracture risk existed. Fracture risk in female celiac patients >50 years is increased overall but is related largely to the peri-diagnostic period. Wrist fracture risk is partly accounted for by height and weight, but is more common more than 5 years after diagnosis. Celiac testing may be indicated in thin women over 50 years with multiple fractures, and after diagnosis adequate calcium and vitamin D intake should be ensured.