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991.
992.
993.
目的:研究自由基在幼年鼠内毒素性脑水肿发病机理中的作用。方法:65只幼鼠,随机分为对照组(C组),单纯内毒素组(LPS组),静注免疫球蛋白治疗组(IVIG组)。于处理后2、6、12、24h(每时间点6-9只)取脑组织,用常规生化方法测定脑组织匀浆中丙二醛(MDA)、总巯基(TSH)和非蛋白巯基(NPSH)含量。结果:LPS组脑含水量、EB含量及MDA含量均明显高于C组,而TSH和NPSH含量明显低于C组(P<0.05或P<0.01);IVIG组脑含水量、EB含量及MDA含量与LPS组相比则有明显降低,以6h更明显(P<0.05或P<0.01),而TSH和NPSH含量分别在各时间点上比LPS组明显增高,但IVIG对NPSH含量影响与LPS组相比无显著差异(P>0.05),且各时间点与C组相比仍低(P<0.05或P<0.01)。结论:自由基参与了幼年鼠内毒素性脑水肿的发生发展,初步证实IVIG通过影响自由基,具有治疗幼年鼠内毒素性脑水肿的作用。 相似文献
994.
MF1小鼠感染曼氏血吸虫六周后,经主动脉和门静脉灌注收虫.配对的成虫暴露在不含环孢素A及分别含有1微克/毫升、10微克/毫升、20微克/毫升的环孢素A的199型培养液中体外培养.药物导致的虫体损害分别作扫描电镜和透射电镜观察.药物作用后,雄虫外质膜损伤,外皮层基质出现水肿和空泡,分泌体减少.进行性表皮损害、肿胀以及皮(?)缺损最终导致皮质膜和合胞体的崩溃.本结果表明,环孢素A抗曼氏血吸虫的作用方式是直接的.而外皮质似乎是药物首先攻击的部位. 相似文献
995.
F. BRUNET J. P. MIRA C. CERF M. BELGHITH O. SOUBRANE J. L. TERMIGNON† B. RENAUD L. FIEROBE I. HAMY M. MONCHI E. DESLANDE A. BRUSSET† J. F. DHAINAUT 《Artificial organs》1994,18(11):826-832
Abstract: This open clinical study was aimed at testing the hypothesis that an intravascular oxygenator (IVOX) may help to perform permissive hypoventilation in 10 patients with severe ARDS. After initial evaluation, we tried to reduce ventilator settings before and after IVOX implantation. Before IVOX, poor clinical tolerance and worsening oxygenation did not allow for a significant decrease in ventilator settings. With IVOX, peak inspiratory pressure (PIP) was reduced from 47 to 39 cm H2 O (p = 0. 005) and minute ventilation from 13 ± 3. 5 to 11 ± 3 L/min. CO2 removal by IVOX allowed a significant decrease in Paco2 from 66 ± 15 to 59 ± 13 mm Hg. Improvement of oxygenation with IVOX was not signify cant. Furthermore, interruption of oxygen flow through IVOX did not change oxygenation variables. Tolerance of the IVOX device was good, but insertion of the device was followed by a significant decrease in both cardiac index and pulmonary wedge pressure. In conclusion, IVOX improves tolerance of hypoventilation by limiting hypercapnia in ARDS patients. These preliminary results must be confirmed by a randomized controlled study 相似文献
996.
Laurie M. Lomasney John F. Madden Wagdy S. Rizk Lawrence W. Hedlund Salutorio Martinez Robert E. Coleman William J. Richardson H. Dirk Sostman 《Journal of magnetic resonance imaging : JMRI》1994,4(3):441-449
Magnetic resonance (MR) imaging may be a noninvasive method for assessing perfusion of vascularized bone grafts placed for treatment of avascular necrosis. One proximal femur of seven beagles was devascularized, with insertion of a vascularized fibular graft. MR imaging at 1 week (seven dogs) and 6 weeks (five dogs) after surgery included pre- and postcontrast spin-echo sequences, unenhanced twodimensional time-of-flight (TOF) vascular imaging, and dynamic gradient-echo imaging during infusion of gadolinium. Relative signal intensity values of selected regions obtained from the dynamic gradientecho images were plotted as percent enhancement versus time. In the operated hip, MR imaging did not show enhancement in six of seven femoral heads and greater trochanters at 1 week after surgery, with similar results after 6 weeks. MR imaging of fibular grafts 6 weeks after surgery showed an initial rapid increase in enhancement and a subsequent slower increase in five of five dogs, although no enhancement was seen in six of seven dogs at 1 week. These findings contrasted with a rapid initial increase in enhancement followed by slow decline in non-operated hips. Two-dimensional TOP imaging did not show the vascular pedicle of the graft in any dog. Findings of radionuclide bone scanning performed 1 week after surgery were consistent with devascularization of the operated femur and fibular graft. However, tetracycline distribution and histologic findings confirmed the viability of five of five grafts within the devascularized femurs 6 weeks after surgery. Thus, dynamic contrast-enhanced MR imaging at 6 weeks after surgery is valuable for assessing vascular bone graft perfusion, while similar imaging at 1 week may suggest otherwise. 相似文献
997.
Optic nerve injury demonstrated by MRI with STIR sequences 总被引:1,自引:0,他引:1
S. Takehara T. Tanaka K. Uemura Y. Shinohara T. Yamamoto T. Tokuyama A. Satoh 《Neuroradiology》1994,36(7):512-514
We studied nine patients with optic nerve injury associated with closed head trauma by magnetic resonance imaging (MRI) with short inversion time inversion recovery (STIR) sequences on 11 occasions from 4 days to 14 years after the injury: three studies were within 17 days and eight over 4 months to 14 years. MRI revealed abnormal high signal in 10 of the 11 injured nerves. MRI 4 days after the injury showed no abnormality. 相似文献
998.
显微神经外科技术及翼点入路在鞍区肿瘤手术的应用 总被引:1,自引:0,他引:1
目的:总结98例鞍区肿瘤患者经翼点入路显微手术治疗及翼点入路应用体会。方法:按照翼点入路各项操作步骤行鞍区肿瘤切除98例,介绍了操作方法并讨论显微神经外科技术在鞍区肿瘤手术中的应用,及不同部位肿瘤作相应手术操作调整的方法。结果:鞍区肿瘤应用翼点入路进行显微手术操作可良好显露鞍区及肿瘤各显微解剖结构以及手术操作平台,使其肿瘤全切率及患者预后得到明显提高。结论:显微神经外科技术及翼点入路手术操作的掌握和熟练程度的提高是显微神经外科技术的关键及获得良好手术效果的基础。 相似文献
999.
Naoto Miyanaga Hideyuki Akaza Shuji Kameyama Takahiko Hachiya Seiichiro Ozono Masao Kuroda Hirofumi Koga Kenkichi Koiso 《International journal of urology》1997,4(6):557-560
Background :
The BTA test is a latex agglutination assay for the qualitative detection in the urine of analytes that are associated with bladder tumor. We compared the results of the BTA test with those of voided urine cytology (VUC) in patients with bladder cancer.
Methods :
A multicenter trial was performed at 6 institutions. A total of 132 patients with histologically diagnosed bladder cancer were enrolled. Urine samples were split for BTA and VUC testing.
Results :
The sensitivities of the BTA test and VUC were 57.6% and 37.9%, respectively; this difference was significant ( P < 0.001). The BTA test had much higher sensitivity for small, solitary, superficial tumors than did VUC.
Conclusion :
The BTA test is simple to perform, gives rapid results, and is far more sensitive than VUC for detection of bladder cancer. The BTA test has the potential to become an additional tool for detecting bladder cancer. 相似文献
The BTA test is a latex agglutination assay for the qualitative detection in the urine of analytes that are associated with bladder tumor. We compared the results of the BTA test with those of voided urine cytology (VUC) in patients with bladder cancer.
Methods :
A multicenter trial was performed at 6 institutions. A total of 132 patients with histologically diagnosed bladder cancer were enrolled. Urine samples were split for BTA and VUC testing.
Results :
The sensitivities of the BTA test and VUC were 57.6% and 37.9%, respectively; this difference was significant ( P < 0.001). The BTA test had much higher sensitivity for small, solitary, superficial tumors than did VUC.
Conclusion :
The BTA test is simple to perform, gives rapid results, and is far more sensitive than VUC for detection of bladder cancer. The BTA test has the potential to become an additional tool for detecting bladder cancer. 相似文献
1000.
目的评价磁共振尿路成像(Magneticresonanceurography,MRU)对泌尿系疾病的诊断价值。方法对36例泌尿系疾病患者进行MRU检查,并结合临床手术、病理资料和其他影像学资料进行回顾性分析。结果36例患者中,均有MRU阳性结果,3例肾盂、肾盏癌,4例前列腺癌,8例前列腺增生症,2例输尿管癌定性、定位明确;9例肾盂、输尿管移行段梗阻定位明确,定性有帮助;10例输尿管下段梗阻中6例诊断明确,4例未能确诊。结论MRU在泌尿系疾病的诊断中,对肿瘤的定位、定性参考价值较高,对尿路梗阻定位诊断有价值,对定性诊断帮助有其局限性。 相似文献