自拟石银退热灵灌肠治疗小儿外感发热132例临床观察

目的:观察自拟石银退热灵灌肠治疗小儿外感发热的疗效。方法:将外感发热患儿260例随机分为治疗组132例与对照组128例,2组患者在进行常规抗感染治疗的同时,治疗组予自拟石银退热灵保留灌肠治疗,对照组予布洛芬口服液,2~3天后观察2组患者的临床疗效。结果:治疗组治愈率及总有效率均高于对照组,差异有统计学意义(P0.05),治疗组退热时间、退热效果与对照组比较,差异有统计学意义(P0.05)。结论:石银退热灵灌肠治疗小儿外感发热不仅起效快,且作用持续时间长     

论《伤寒论》科研

金东明教授在中医经典《伤寒论》博、硕、本教学、临床与研究经验中,对如何做好《伤寒论》科研,在意义目的、选题领域、研究方法、成果评价、注意事项、择优先行6个方面首次从中医药高校教学角度,针对各专业、博硕本三级,系统探讨《伤寒论》科研内容与方法,目前国内外尚无同类研究报道.     

Study on the value of exogenous bFGF in the treatment of brain injury

Objective:To investigate the relation between necrosis and apoptosis in the hippocampus of exogenous bFGF on this process.Methos:With Marmarou‘s method we produced a severe diffuse brain injury and studied the changes in the hippocampus by adapting a modified TdT-mediated dUTP-biotin nick end labeling (TUNEL) method.At the same time we observed the effect of exogenous bFGF on neuronal necrosis and apoptosis.Results:We found that together with cell necrosis there was an increase in the number of apoptotic neurons in the hippocampus CA2-3 sectors as early as 4h after injury,with numbers reaching a maximum at 7d.Exogenous bFGF resulted in a definite reduction in the amount of necrosis and apoptosis.Conclusions:Neuronal necrosis and apoptosis occur in combination after brain injury and that one of the causes may be the insufficience expression of the bFGF gene in the hippocampus after severe injury.Exogenous bFGF and similar substance may prove clinically useful after brain injury by reducing cell necrosis and apoptosis.     

伤口组织与电刺激调控的相关性研究

慢性伤口迁延不愈。外源性电刺激提供促进慢性伤口愈合的电流,其独特优势是使电荷调控伤口,促进伤 口愈合,具有良好的应用前景,并成为目前组织学研究者和临床医生的研究热点之一。现介绍一些常见慢性伤口 的形态学和电生理特性,主要探讨目前电荷调控伤口愈合的形态学改变、可能作用机制及其影响因素。     

Drinking patterns within households: the estimation and interpretation of individual and group variables

Levels of alcohol consumption tend to be similar for individuals living in the same household. This may be because: (a) individuals with similar characteristics collect in households (correlated effects); (b) individuals in the same household are influenced by common factors (exogenous effects); and/or (c) the consumption levels of an individual directly influences the consumption levels of other individuals in the same household (endogenous effects). Whichever of these three possibilities is the principal reason underlying household clustering of consumption levels has important policy implications. In this paper we propose a testing strategy to distinguish between the three types of effect in a cross-sectional data-set. Allowing for exogenous or endogenous effects shows that the significant socio-economic gradient in a model containing only individual variables arises because of misspecification. However, because we find significant evidence of correlated effects, we cannot identify whether it is endogenous or exogenous effects which give rise to statistically significant group level variables. The results indicate the possible pitfalls of omitting group level influences.Copyright © 1998 John Wiley & Sons, Ltd.     

银翘散加味治疗小儿疱疹性口炎(外感风热型)22例

[目的]观察银翘散加味治疗小儿外感风热型疱疹性口炎的临床疗效。[方法]对22例6个月至3岁患儿,采用银翘散加味治疗。[结果]显效率55.45%,有效率36.36%,总有效率90.91%,显效疗程3天。[结论]银翘散加味治疗小儿外感风热型疱疹性口炎效果良好,值得临床推广应用。     

辨别外感病机,学用伤寒经方治疗热邪伤肺型咳嗽

治疗外感咳嗽,首要的是辨别外感病机,"得其机要,则动小而功大,用浅而功深"。肺一方面能将卫气和津液等布散于周身体表,温润肌腠和皮毛;一方面皮毛参与肺"一呼一吸,消息自然"的气体交换。肺外合皮毛的生理关系,决定了外感引发咳嗽的病理关系。正气强盛,邪不可干;外邪袭人致病,必乘其虚;寒暑湿燥火,多依附于风而侵犯人体,且多兼风夹气为患,故称"风为六淫之首,百邪之先"。内有伏饮,即是病理产物,也是致病因素,是易招外邪的内在原因;而究伏饮所由生,仍是之前遭遇六淫侵袭所致。学用伤寒经方治疗热邪伤肺咳嗽,要在辨别病机,循证辨因,对症选方,灵活用药,每可应手取效。     

张立山教授从三阳合病论治小儿外感发热经验

[目的]总结导师张立山教授从三阳合病论治小儿外感发热的经验。[方法]通过查找阅读相关文献资料,论述小儿外感发热易三阳合病的特点,对导师张立山教授论治小儿外感发热的经验加以总结,并附验案二则加以佐证。[结果]张师认为小儿纯阳之体,脏腑娇嫩,易外感内伤而发热。针对其易从阳化热及常兼食滞、痰饮的病因病机,从三阳合病论治小儿外感发热,切中病机,疗效较佳。所举化脓性扁桃体炎及小儿不明原因反复发热两则验案均符合三阳合病病机,从此入手,以少阳代表方小柴胡汤为基础,再加太阳、阳明相关方剂,合方加减,均取得了满意的临床疗效。[结论]从三阳合病论治小儿外感发热,切中病机,可达迅速退热之效,具有临床应用价值,值得进一步推广运用。     

Quantification of Interactions between Serum Albumin and Endogenous Free Fatty Acids or Exogenous Chemicals by Stable Isotope-Coded Mass Spectrometry

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