绵毛黄芪苷和苦玄参苷的中枢抑制作用

报道了绵毛黄芪苷(SK)及其同类结构苦玄参苷(PIA)给予昆明种式BLC_(57)/1小鼠50mg/kg腹腔注射能明显延长硫贲妥钠的睡眠时间,用扭体法或热板法证实同量SK或PIA静脉注射能产生明显的镇痛作用。用格斗试验证实:同量SK或PIA腹腔注射可使小鼠格斗试验次数明显减少。提示两种苷可能具有中枢镇静、镇痛和安定作用;此类中枢抑制作用说明四环三萜皂苷类具有药用价值的前景。     

Phobic postural vertigo: a first follow-up

Seventy-eight patients with phobic postural vertigo (PPV) and 17 patients with psychogenic disorder of stance and gait (PSG) were asked to evaluate their condition 6 months to 5.5 years after their original referral and short-term psychotherapy. Two results seem most important: (1) PPV had a favourable course with a 72% improvement rate (22% of patients becoming symptom free), whereas the majority of patients with PSG (52%) remained unchanged; (2) the majority of patients with PPV experienced complete remission or considerable improvement even if their condition had lasted between 1 and 20 years prior to diagnosis. Complete remission of PSG was observed only if the disorder had been present less than 4 months; there was no improvement if it had lasted longer than 2 years. PPV can be defined as a distinct clinical entity with a relatively benign course. It can be reliably diagnosed on the basis of typical features.     

Regulation of fluid intake in dogs following water deprivation

Whereas water loss in land living animals occurs continuously, water intake takes place discontinuously. At the normal operating set point of plasma osmolality, urine is more concentrated than plasma due to secretion of vasopressin. Thus animals operate around a state of mild dehydration. As water loss occurs, the severity of dehydration and thirst increase in intensity and at some point water intake occurs. Sufficient water is consumed to return plasma osmolality to the normal operating set point. Food intake and water balance are interdependent as food provides the osmoles which determine obligatory renal solute excretion. When dry food with the same osmotic content was substituted for canned food (water content 74%), dogs increased water intake from 24.2 +/- 4.3 to 62.2 +/- 8.8 ml/kg. Urine output and urine osmolality were unchanged, as under conditions of normal hydration, near maximal urine concentration is achieved. Changing water intake is the only available variable to maintain water balance. During water deprivation, the major renal mechanism appears to be natriuresis. In rehydration, satiety mechanisms ensure appropriate water intake and renal sodium conservation restores sodium balance.     

2%HPMC对兔眼内压及角膜内皮影响的实验研究

报导了2%羟丙基甲基纤维素(HPMC)、1%透明质酸钠(Na-HA)及平衡盐液(BSS)分别注入兔眼前房后,其眼内压、角膜内皮细胞数及内皮细胞形态的变化。证实自制2%HPMC 与进口1%Na-HA 性能基本相同,仅有一过性眼压升高,不损害角膜内皮,能在眼前节手术及人工晶体植入时有效地保护角膜内皮细胞。     

小叶锦鸡儿的药理作用

小叶锦鸡儿１ｇ／ｋｇ，０．５ｇ／ｋｇ灌胃给药明显地提高小鼠热痛阈（Ｐ＜０．００１），减少酒石酸锑钾所致的小鼠扭体反应次数（Ｐ＜０．０１），对抗二甲苯所致小鼠耳壳炎症（Ｐ＜０．０１），抑制蛋白加热变性（Ｐ＜０．０１），明显地降低氯仿诱发的小鼠室颤发生率。     

Cleft lip-nose repair technique: Sequential repair

The results of repairing cleft lip by aesthetic plastic surgery are now excellent. However, the cleft lipnose deformity is still very difficult to repair with the present techniques. A technique that can repair the cleft lip-nose deformity with good results is presented. The technique is divided into three parts: Part I consists of nasal repair of the primary cleft lip. Part II is nasal reconstruction as a secondary operation with or without lip repair. For example, nasal reconstruction may be secondary to repair of deformities of the sill, rim, limen nasi, septum, or nasal bones. Part III is an aesthetic nasal operation such as rhinoplasty, mentoplasty, or zygomaplasty.     

THE ROLE OF P_1-PURINERGIC RECEPTORS IN THE SPINAL MECHANISMS OF ACUPUNCTURE ANALGESIA

It has been extensively proved that electro-acupuncture elicit analgesia in bothextensive areas and local region via supraspinal structures and spinal cord.The present investigationwas to study the role of P_1-purinergic receptors in the spinal mechanisms of weak electroacupuncture-induced analgesia.Leg withdrawal latency(LWL)to noxious radiant heat focused on the ankle regionwas used to assess the effects of acupuncture and that of P_1-purinergic(adenosine)receptor antago-nists,theophylline and caffeine on the electro-acupuncture(EA)analgesia.EA prolonged the LWLby 16.7%±20.3%,with an after-effect lasting about 15 min.Both theophylline and caffeineblocked the EA-induced prolongation of LWL in a dose-dependent manner at the doses of 1.6-16 mg/kg.These results suggest that P_1-purinegic receptor is involved in the spinal mechanisms of weak EAproduced analgesia in the rat.     

钙剂加维生素D治疗对糖尿病患者钙代谢的影响

本文报道NIDDM患者在常规治疗的基础上加用钙剂和维生素D治疗后的钙代谢变化。糖尿病患者单纯用常规治疗控制血糖后,负钙平衡不能完全纠正,而加用钙剂和维生素D治疗后,负钙平衡能完全纠正,并且高于正常对照组平衡值(P<0.01)。说明钙剂加维生素D治疗对糖尿病性骨质疏松是有益的。     

医院电子天平维护计量情况统计分析

电子天平具有体积小，功能齐全，操作简单，数值直观等优点，正为愈来愈多的医院、学校、科研单位所使用。本文结合我院五年中电子天平的使用、维护、计量情况，统计分析了其常见故障及电子天平使用中的注意事项。对保证医院电子天平使用过程的量值准确，提高临床诊断及科研水平有所帮助。     

新法加工附子与附片抗炎镇痛作用比较研究

目的：比较新法加工附子在总生物碱高于附片13倍时，其抗炎、镇痛的效果是否有差异。方法：通过小鼠热板法、扭体法、小鼠耳廓肿胀法和大鼠足趾肿胀法进行镇痛和抗炎作用比较。结果：二者对热板法小鼠的痛阈值均无提高．均能减少酒石酸钾所致小鼠扭体次数．对二甲苯所致小鼠耳廓肿胀和角叉菜胶所致大鼠足趾肿胀具有抑制作用。但二者之间比较差异无显著性。结论：新法加工附子保存了其原有疗效，但和总生物碱无量效相关性，其中是否有新的活性成份，有待进一步研究探讨。