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991.
992.
Complete deficiency of hypoxanthine guanine phosphoribosyltransferase (HPRT) causes Lesch-Nyhan syndrome. We examined the HPRT gene mutation for prenatal diagnosis in a Japanese family. A single nucleotide substitution of C to T in exon 3 was identified by direct sequencing analysis of the HPRT gene of a Lesch-Nyhan patient. This substitution resulted in a nonsense mutation, CGA (Arg) to TGA (stop), at codon 51. Utilizing an Xho I restriction site which was lost in the mutation as an indicator, a family study showed that the mother was heterozygous, but the grandmother normal. By the same method, prenatal genetic diagnosis was performed using chorionic villus samples (CVS), and showed that the fetus had the mutant allele. 相似文献
993.
K. Fukushima C. Harada J. Fukushima Y. Suzuki 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1990,79(1):25-42
Summary 1. Maximal activation directions of vertical burst-tonic and tonic neurons in the region of the interstitial nucleus of Cajal (INC) were examined in alert cats during vertical vestibulo-ocular reflex induced by sinusoidal rotation (at 0.11 Hz±10 deg, or 0.31 Hz±5 deg) in a variety of vertical planes using a null point analysis. The results were compared with the angles of anatomical and functional planes of vertical canals reported by Blanks et al. (1972) and Robinson (1982), and with the angles of vertical eye muscles measured in this study and by Ezure and Graf (1984). 2. Maximal activation directions of 23 cells (21 burst-tonic and 2 tonic neurons) were determined from their responses during rotation in 4 or more different vertical planes. All cells showed sinusoidal gain curves and virtually constant phase values except near the null regions, suggesting that their responses were evoked primarily by canal inputs. Phase values of 5 cells near the null regions depended on the rotation plane, suggesting additional otolith inputs. We used a measurement error range of ±10 deg for calculating the maximal activation directions from the null regions of individual cells and the values of error ranges of null calculation. Of the 23, the maximal activation directions of 7 cells were outside the measurement error ranges of vertical eye muscle angles and within the ranges of vertical canal angles (class A), those of 5 cells were within the ranges of eye muscle angles and outside the ranges of vertical canal angles (class B), and those of the remaining 11 cells were in the overlapping ranges for both angles (class C). Even if only the cells in which 5 or more measurement points were taken to determine maximal activation directions (n = 15), the results were similar. During vertical rotation with the head orientation +60 deg off the pitch plane, dissociation of cell activity and vertical compensatory eye movement was observed in 5 cells in class A or C that had null angles near +45 deg. These results suggest that the cells in class A and B carried individual vertical canal and oculomotor signals, respectively, although it is difficult to tell for the majority of cells (class C) which signals they reflected. Some cells in class A and C were antidromically activated from the medial longitudinal fasciculus at the level of abducens nucleus, suggesting that the signals carried by these cells may be sent to the lower brainstem. 3. Most burst-tonic neurons did not respond to horizontal rotation; significant responses were obtained in only 3 of 10 cells tested for which the gain was only 14–17% of their maximal vertical gain. There was no clear difference in gain or phase values of the responses to vertical rotation, or in eye position sensitivity (during spontaneous saccades) between cells whose responses coincided with individual vertical canal angles and those matching the angles of vertical recti muscles. The values of phase lag (re head acceleration during pitch rotation) and eye position sensitivity of these cells are still smaller compared to those of extraocular motoneurons reported by Delgado-Garcia et al. (1986), although they were larger than those of secondary vestibulo-ocular neurons (Perlmutter et al. 1988). All these results suggest that the signals carried by burst-tonic and tonic neurons in the INC region are different from oculomotor signals. 4. Similar analysis was done for comparison for 19 other cells that did not show close correlation with spontaneous eye movement but whose activity was clearly modulated by pitch rotation (pitch cells). More than a half (10/19) had maximal activation directions outside the measurement error ranges of individual vertical canal angles, and many shifted towards roll. Horizontal rotation produced responses with higher gain than burst-tonic neurons, suggesting a difference in the spatial response properties of burst-tonic and tonic neurons on one hand and pitch cells on the other. 相似文献
994.
Change‐point detection of cognitive states across multiple trials in functional neuroimaging 下载免费PDF全文
F. Spencer Koerner John R. Anderson Jon M. Fincham Robert E. Kass 《Statistics in medicine》2017,36(4):618-642
Many functional neuroimaging‐based studies involve repetitions of a task that may require several phases, or states, of mental activity. An appealing idea is to use relevant brain regions to identify the states. We developed a novel change‐point methodology that adapts to the repeated trial structure of such experiments by assuming the number of states stays fixed across similar trials while allowing the timing of change‐points to change across trials. Model fitting is based on reversible‐jump MCMC. Simulation studies verified its ability to identify change‐points successfully. We applied this technique to data collected via functional magnetic resonance imaging (fMRI) while each of 20 subjects solved unfamiliar arithmetic problems. Our methodology supplies both a summary of state dimensionality and uncertainty assessments about number of states and the timing of state transitions. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
995.
Adaptive enrichment designs are an attractive option for clinical trials that aim at demonstrating efficacy of therapies, which may show different benefit for the full patient population and a prespecified subgroup. In these designs, based on interim data, either the subgroup or the full population is selected for further exploration. When selection is based on efficacy data, this introduces bias to the commonly used maximum likelihood estimator. For the situation of two‐stage designs with a single prespecified subgroup, we present six alternative estimators and investigate their performance in a simulation study. The most consistent reduction of bias over the range of scenarios considered was achieved by a method combining the uniformly minimum variance conditionally unbiased estimator with a conditional moment estimator. Application of the methods is illustrated by a clinical trial example. 相似文献
996.
997.
目的:观察玫瑰解郁汤联合穴位埋线及耳穴贴压疗法治疗血液透析患者抑郁症的临床疗效。方法:选取患有抑郁症的血液透析患者66例,随机分为观察组和对照组,每组各33例。观察组采用玫瑰解郁汤联合穴位埋线、耳穴贴压治疗,对照组单纯采用玫瑰解郁汤治疗。观察治疗后两组患者汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分及抑郁自评量表(self-rating depression scale,SDS)评分,评价临床疗效。结果:治疗后两组患者HAMD评分及SDS评分均较治疗前降低,观察组优于对照组,两组比较,差异有统计学意义(P0.05);观察组有效率84.9%,对照组有效率57.6%,两组比较,差异有统计学意义(P0.05);两组治疗期间均未出现明显不良反应。结论:玫瑰解郁汤联合穴位埋线、耳穴贴压疗法治疗血液透析患者抑郁症效果明显,无明显不良反应。 相似文献
998.
目的:观察中药包外熥配合艾灸委中穴治疗寒湿闭阻型腰痛的临床疗效,并探讨其效应与作用机制。方法:选取96例确诊为寒湿闭阻型腰痛患者随机分为治疗组和对照组各48例,治疗组采用中药包循经外熥配合艾灸委中穴治疗,对照组给予口服洛索洛芬钠片及腰椎推拿治疗,两组均以10 d为1个疗程,分别于第1个疗程、第2个疗程后观察两组患者腰痛相关症状、体征等改善情况,通过观察两组患者视觉模拟评分法(visual analogue scale,VAS)评分、日本腰椎骨科协会下腰痛(japanese orthopaedic association scores,JOA)评分和Oswestry功能障碍指数问卷表(oswestry disability index,ODI)评分的变化情况对其效应进行分析与评估,于1个月后采用患者自填健康调查表(MOS 36-ltem short form health survey,SF-36)评估生存质量,并分析各组临床疗效,3个月后随访分析各组复发率。结果:两组患者VAS评分和ODI评分均有所减少,较对照组,治疗组减少更为明显(P0.05);两组患者JOA评分中主观症状、临床体征和日常活动受限度比较,其评分均有增加,较对照组,治疗组JOA评分增加更为明显(P0.05),两组膀胱功能比较,差异无统计学意义(P0.05);两组患者SF-36评分均增高,较对照组,治疗组增高更为明显(P0.05);治疗组效率为93.75%,治愈率68.75%,3个月后复发率4.17%,均显著优于对照组(P0.05)。结论:温经通督药熥法配合艾灸委中穴治疗寒湿闭阻型腰痛,疗效显著。 相似文献
999.
目的 观察艾灸肺俞穴治疗儿童哮喘冷哮证急性发作的临床疗效,为针灸治疗哮喘提供临床证据。方法 选取符合研究标准的哮喘冷哮证患儿87例,随机分为2组,对照组予以常规西药治疗,观察组在常规西药治疗的基础上予以艾灸双侧肺俞穴治疗,观察CRP、IgE、IL-1、IL-6、EOS水平及肺功能和症状积分的变化,对比2组患儿临床疗效。结果 治疗后观察组CRP、IgE、IL-6、EOS等指标水平均明显低于对照组(P<0.05~0.01);观察组FEV1、PEF水平明显优于对照组(P<0.05);观察组症状积分明显低于对照组(P<0.05);观察组显效率(73.81%)明显高于对照组(53.33%,P<0.05)。结论 艾灸肺俞穴治疗儿童哮喘冷哮证急性发作,可以明显降低患儿CRP、IgE、IL-6、EOS水平,改善肺功能,临床疗效显著。 相似文献
1000.
[目的]观察康视明合剂联合耳穴贴压治疗视疲劳临床疗效。[方法]将86例视疲劳患者随机分为治疗组43例用康视明合剂联合耳穴贴压治疗,对照组43例服用杞菊地黄丸。观察明视持久度测定和视疲劳症状积分变化情况,并评价临床疗效。[结果]治疗组的临床综合疗效、明视持久度及视疲劳症状积分改善均优于对照组,差异有统计学意义(P<0.05)。[结论]应用康视明联合耳穴贴压可有效治疗视疲劳,可以显著改善明视持久度及视疲劳症状。 相似文献