化妆品中15种防晒剂测定方法的优化

目的：改进和优化《化妆品卫生规范》2007年中15种防晒剂的HPLC测定法,以便更好地对化妆品中限用的化学防晒剂进行质量监控。方法：采用经改进的混合液提取样品,以Accurasil C18（250 mm×4.6 mm,5μm）为分析色谱柱,甲醇-四氢呋喃-水（冰醋酸调pH至2.60）为流动相梯度洗脱,流速：1.0 ml·min^-1,柱温：25℃,检测波长：311 nm。结果：15种防晒剂的线性良好,在0.85%-1.56%之间,r均〉0.999 5,检出限为1.9-18.7 ng,方法回收率为97.5%-113.7%,RSD（n=9）。结论：改进后的方法结果可靠,对《化妆品卫生规范》2007版防晒剂测定方法是有效的优化和补充。     

急性StanfordA型主动脉夹层孙氏手术后机械通气时间延长的危险因素分析

目的评估欧洲评分Ⅱ是否能够有效预测急性Stanford A型主动夹层孙氏术后机械通气时间,探索孙氏术后机械通气时间延长的危险因素。方法自2009年12月至2012年2月共240例急性Stanford A型主动脉夹层的患者纳入研究。术后呼吸机机械通气时间超过48 h定义为机械通气时间延长。计算所有患者的欧洲评分。欧洲评分的区分能力采用受试者工作特征（ROC）曲线评估,校正能力采用Hosmer Lemeshow拟合优度检验评估。结果急性Stanford A型主动脉夹层孙氏术后院内总体病死率为10.0%（24/240）,术后平均呼吸机机械通气时间为17.0（12.5,56.0）h。共74例患者术后机械通气时间延长。欧洲评分Ⅱ的区分能力（ROC曲线下面积=0.52）及校正能力（Hosmer Lemeshow,P〈0.05）均不佳。单因素分析结果显示年龄［比值比（OR）=2.88, P=0.00］、脑卒中病史（OR=1.04,P=0.03）、外周血白细胞计数（OR=3.19, P=0.00）、发病至手术时间小于1周（OR=3.68,P=0.001）、体外循环时间（OR=1.96,P=0.02）为术后院内死亡的危险因素。Logistic多因素分析年龄大于48.5岁（OR=3.85,P=0.00）、术前外周静脉血白细胞计数超过13.5×109/L（OR=4.05, P=0.00）、发病至手术时间小于1周（OR=3.75, P=0.002）是孙氏术后机械通气时间延长的危险因素。结论年龄、术前白细胞计数超过13.5×109/L、发病至手术时间小于1周是孙氏手术后机械通气时间延长的危险因素。欧洲评分Ⅱ不能有效预测急性Stanford A型夹层孙氏手术后机械通气时间延长。术前及术中采取措施减少外周血白细胞计数、减轻炎性反应可能是一种潜在的主动脉手术脏器保护策略。     

孙浩主任医师辨证治疗小儿过敏性鼻炎举隅

介绍孙浩主任医师辨证治疗小儿过敏性鼻炎的经验。认为小儿过敏性鼻炎的基本病机是肺脾气虚,以内服补中益气丸补益正气,外用自拟鼻炎方熏洗鼻腔以宣肺通窍,辨证治疗小儿过敏性鼻炎,疗效甚佳。     

The clinical value of Fibulin-1 for prognosis and its prospective mechanism in intrahepatic cholangiocarcinoma

Background

Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy arising from the liver. Fibulin-1 has been demonstrated to be involved in various cancers, however, its role in ICC remains unclear.

Determinants of inadequate parental sun protection behaviour in their children – Results of a cross-sectional study in Germany

ObjectiveUnprotected sun exposure especially during childhood is a risk factor for skin cancer. A combined use of sun protection measures is recommended to protect children. However, the prevalence and determinants for combined use have been scarcely studied in children. The objective of this study was to identify determinants of parental sun protection behaviour.MethodsA cross-sectional survey was performed in five regions in Bavaria (Germany) during school entrance health examination (2010/2011). Parents of 4579 children (47% female, aged 5–6 years) completed a self-administered questionnaire (response 61%).ResultsMost children were regularly protected with single measures (shade (69%), clothes (80%), hat (83%), sunscreen (89%), sunglasses (20%)). However, regarding regular and combined use, >50% of children were inadequately protected. Larger family size, lower household equivalent income, darker skin and sunburn history were associated with inadequate use of different sun protection measures. The less frequent use of one sun protection measure was associated with less frequent use of the others. Child's sex, migration background, parental education and sun exposure showed inconsistent results regarding the different sun protection outcomes.ConclusionBased on our results a regular, combined and correct use of multiple sun protection for children should be promoted independent of sociodemographic characteristics. Priority of shade, clothes and hat before sunscreen should be clarified.     

子宫背带式缝合治疗剖宫产术中宫缩乏力出血疗效分析

目的探讨子宮背带式缝合治疗剖宫产术中宫缩乏力出血的临床效果。方法回顾性分析2012年6月—2014年1月间来我院接受剖宫产并且术中出现宫缩乏力出血的孕妇87例的临床资料,分析患者术中宫缩乏力出血时采取给中治疗手段的效果。结果 87例术中缩宫乏力出血患者中有37例使用了按摩压迫子宫以及药物治疗止血,其中有13例起效,未起效的患者与其他患者采用子宮背带式缝合治疗,均成功止血,37例常规止血患者平均出血量为（950±30.4）mL,50例子宮背带式缝合患者出血量为（540±21.4）mL。结论与其他止血方式相比,子宮背带式缝合治疗剖宫产术中宫缩乏力出血具有明显优势,用于临床取得了显著效果,因此适合临床推广使用。     

基于SunONE平台的医院进修生信息管理系统

采用基于J2EE的Sun ONE架构开发进修生信息管理系统,具有可集成性和便于操作的优点.应用该系统可对进修申请、收费确认、学员在院、离院等进行规范化管理,不仅提高了科学管理水平,而且优化了管理工作流程.使用本系统以来,对进修生管理手段更加科学化,增加了各个部门之间的协调力度,提高了办事效率.     

拟缺香茶菜的化学成分研究

目的研究拟缺香茶菜Rabdosia excisoides的化学成分。方法利用硅胶柱色谱法进行分离和纯化,通过谱学分析鉴定单体化合物结构。结果从拟缺香茶菜分离鉴定2个化合物,化合物Ⅰ命名为拟缺香茶菜甲素(excisoidesinA);化合物Ⅱ鉴定为齐墩果酸。结论化合物Ⅰ为首次发现的新二萜成分。