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991.
【摘要】 目的 探讨125I粒子植入治疗肝细胞癌(HCC)多发肺转移瘤的临床疗效及其预后的影响因素。方法 回顾性分析陆军军医大学第一附属医院微创介入与放射性粒子诊疗中心45例行CT引导下125I粒子植入治疗HCC 多发肺转移瘤患者的临床及影像资料。随访观察肿瘤近期局部疗效及并发症,用Kaplan-Meier法分析粒子植入后的总体生存率,用Cox比例风险模型对潜在危险因素进行多变量分析。结果 共对177个肺转移瘤进行粒子植入治疗,6个月后评估近期疗效显示46.3%的肺转移瘤为CR、32.8%的肺转移瘤为PR、11.3%的肺转移瘤为SD、9.6%的肺转移瘤为PD;DCR为90.4%。中位随访期为22个月,粒子植入后1年、2年和3年的OS率分别为71.1%、45.7%和25.7%。血管侵犯(HR=3.01,95%CI:1.26~7.21,P=0.01)、肺转移瘤的数量(HR=2.69,95% CI: 1.05~6.89,P=0.04)是粒子植入治疗HCC 多发肺转移瘤的独立危险因素。结论 CT引导下125I粒子植入是HCC 多发肺转移瘤患者的治疗选择,且无血管侵犯及肺转移瘤数≤3的患者125I粒子植入治疗后的生存预后更好。 相似文献
992.
克拉霉素,甲硝唑和兰索拉唑联合治疗幽门螺杆菌感染的临床疗… 总被引:22,自引:0,他引:22
本文报道克拉霉素与甲硝唑及兰索拉唑联合应用治疗HP阳性的十二指肠溃疡。方法:59例符合条件的病人随机分成两个治疗组,其中30例口服克拉霉素250mg,甲硝唑400mg,兰索拉唑30mg,另一组29例口服克拉霉素500mg,甲硝唑400mg,兰索拉唑30mg,用法均为每日2次,疗程1周,继而口服兰索拉唑30mg,每日1次,共1周。疗程结束后1个月复查胃镜。 相似文献
993.
幽门螺杆菌感染的药物治疗 总被引:6,自引:0,他引:6
幽门螺杆菌感染的药物治疗孙钢,陈寿坡自1983年Marshall和Warren在胃粘膜发现幽门螺杆菌(Helicobacterpylori,HP)以来,其与多种慢性上消化道疾病的关系受到广泛的关注。目前认为:(1)HP感染与慢性胃炎具有明确的因果关系... 相似文献
994.
扶正祛邪法治疗Hp阳性DU 37例 总被引:1,自引:0,他引:1
扶正祛邪法治疗Hp阳性DU37例杨占文1张莲娇2杨力31空军公主岭医院吉林省公主岭市1361002公主岭市医院3白求恩医科大学SubjectheadingsHelicobacterinfections/zhongyiyaoliaofaDuoden... 相似文献
995.
胃黏膜保护剂的药理作用和应用评价 总被引:1,自引:0,他引:1
一、胃黏膜保护剂的概念和分类
胃黏膜损伤因子包括内源性因子如高浓度胃酸、胃蛋白酶、幽门螺杆菌(Hp)、十二指肠液和外源性因子如非甾体类抗炎药(NSAID)、乙醇等。胃黏膜具有下列防御和修复机制,包括黏液-碳酸氢盐屏障、黏膜屏障、黏膜下血流量、细胞更新、前列腺素(prostaglandins,PG)和生长因子等。 相似文献
996.
胆汁反流是多种消化系疾病的病因之一,它与幽门螺杆菌(Hp)感染及十二指肠溃疡的发病关系尚不清楚。本文旨在探讨胆汁反流与Hp感染及十二指肠溃疡的发病关系。 相似文献
997.
Risk factors of pancreatic leakage after pancreaticoduodenectomy 总被引:16,自引:1,他引:16
Yang YM Tian XD Zhuang Y Wang WM Wan YL Huang YT 《World journal of gastroenterology : WJG》2005,11(16):2456-2461
AIM: To analyze the risk factors for pancreatic leakage after pancreaticoduodenectomy (PD) and to evaluate whether duct-to-mucosa pancreaticojejunostomy could reduce the risk of pancreatic leakage. METHODS: Sixty-two patients who underwent PD at our hospital between January 2000 and November 2003 were reviewed retrospectively. The primary diseases of the patients included pancreas cancer, ampullary cancer, bile duct cancer, islet cell cancer, duodenal cancer, chronic pancreatitis, pancreatic cystadenoma, and gastric cancer. Standard PD was performed for 25 cases, PD with extended lymphadenectomy for 27 cases, pylorus-preserving PD for 10 cases. A duct-to-mucosa pancreaticojejunostomy was performed for patients with a hard pancreas and a dilated pancreatic duct, and a traditional end-to-end invagination pancreaticojejunostomy for patients with a soft pancreas and a non-dilated duct. Patients were divided into two groups according to the incidence of postoperative pancreaticojejunal anastomotic leakage: 10 cases with leakage and 52 cases without leakage. Seven preoperative and six intraoperative risk factors with the potential to affect the incidence of pancreatic leakage were analyzed with SPSS10.0 software. Logistic regression was then used to determine the effect of multiple factors on pancreatic leakage. RESULTS: Of the 62 patients, 10 (16.13%) were identified as having pancreatic leakage after operation. Other major postoperative complications included delayed gastric emptying (eight patients), abdominal bleeding (four patients), abdominal abscess (three patients) and wound infection (two patients). The overall surgical morbidity was 43.5% (27/62). The hospital mortality in this series was 4.84% (3/62), and the mortality associated with pancreatic fistula was 10% (1/10). Sixteen cases underwent duct-to-mucosa pancreaticojejunostomy and 1 case (1/16, 6.25%) developed postoperative pancreatic leakage, 46 cases underwent invagination pancreaticojejunostomy and 9 cases (9/46, 19.6%) developed postoperative pancreatic leakage. General risk factors including patient age, gender, history of jaundice, preoperative nutrition, pathological diagnosis and the length of postoperative stay were similar in the two groups. There was no statistical difference in the incidence of pancreatic leakage between the patients who received the prophylactic use of octreotide after surgery and the patients who did not undergo somatostatin therapy. Moreover, multivariate logistic regression analysis showed that none of the above factors seemed to be associated with pancreatic fistula. Two intraoperative risk factors, pancreatic duct size and texture of the remnant pancreas, were found to be significantly associated with pancreatic leakage. The incidence of pancreatic leakage was 4.88% in patients with a pancreatic duct size greater than or equal to 3 mm and was 38.1% in those with ducts smaller than 3 mm (P = 0.002). The pancreatic leakage rate was 2.94% in patients with a hard pancreas and was 32.1% in those with a soft pancreas (P = 0.004). Operative time, blood loss and type of resection were similar in the two patient groups. The incidence of pancreatic leakage was 6.25% (1/16) in patients with duct-to-mucosa anastomosis, and was 19.6% (9/46) in those with traditional invagination anastomosis. Although the difference of pancreatic leakage between the two groups was obvious, no statistical significance was found. This may be due to the small number of patients with duct-to-mucosa anastomosis. By further analyzing with multivariate logistic regression, both pancreatic duct size and texture of the remnant pancreas were demonstrated to be independent risk factors (P = 0.007 and 0.017, OR = 11.87 and 15.45). Although anastomotic technique was not a significant factor, pancreatic leakage rate was much less in cases that underwent duct-to-mucosa pancreaticojejunostomy. CONCLUSION: Pancreatic duct size and texture of the remnant pancreas are risk factors influencing pancreatic leakage after PD. Duct-to-mucosa pancreaticojejunostomy, as a safe and useful anastomotic technique, can reduce pancreatic leakage rate after PD. 相似文献
998.
魏卫 《寄生虫病与感染性疾病》2006,4(3):155-155
我国北方以十二指肠钩虫感染为主,南方以美洲钩虫感染为主,为了解地处南北交界的大别山区信阳市3县农村钩虫感染情况,现将2001-08所作的调查结果报道如下。1对象与方法采用整群随机抽样的方法,根据各县、区经济情况、卫生条件和文化水平,以3县区14乡常住人口为对象,每乡调查550 相似文献
999.
1000.
胆汁反流、胃酸和幽门螺杆菌感染共同作用对胃黏膜损伤程度和分布的影响 总被引:8,自引:0,他引:8
背景:胆汁反流、胃酸和幽门螺杆菌(H.pylori)感染均是胃黏膜损伤的独立致病因素。然而,它们共同存在时有无协同致病作用尚不清楚。目的:探讨胆汁反流、胃酸和H.pylori感染共同作用对胃黏膜损伤程度和分布的影响。方法:37例胃镜检查疑有十二指肠胃反流者均经24h胃内胆汁监测证实,同时行胃内PH监测。胃体和胃窦黏膜有或无活动性炎症、萎缩、肠化和不典型增生分别记2分或1分。分别以胃体和胃窦黏膜的各项病理学改变为应变量,以胃内胆红素吸收值>0.14的时间百分比、pH<4的时间百分比和H.pylori感染状态指标为自变量进行多变量逐步Logistic回归分析。结果:37例患者胃内胆红素吸收值>0.14的时间百分比为34.49%±22.69%,pH<4的时问百分比为78.68%土 9.91%,H.pylori阳性率为29.73%。胆汁反流出现在以胃体和胃窦黏膜肠化以及胃体黏膜活动性炎症为应变量的Logistic回归模型中,H.pylori出现在以胃体黏膜活动性炎症为应变量的回归模型中。结论:胆汁反流是胃黏膜肠化的危险因素;胃内有胆汁反流存在时,H.pylori感染是导致胃体新膜炎症的重要病因。 相似文献