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艾滋病相关卡波西肉瘤32例尸检材料病理学研究 总被引:4,自引:1,他引:3
目的:概况艾滋病相关卡产波西肉瘤(KS)病理特征,并探讨其两全是学分型、来源与性质。方法:所有病例均按常规尸检及制片,光镜观察,并复习资料。结果:KS累及皮肤23例,呼吸系统20例,消化道17例,淋巴结12例,26例为播散性。肿瘤肉眼表现为斑型和结节型,镜下主要同增生的血管和梭形细胞构成。并常见胶原分、淋这扩张、嗜性小体、炎细胞浸浸、出血及含铁务黄素沉积等特征性病变。结论:KS是一种颇具特征的病变 相似文献
94.
Background : Osseous cranial base tumours in children present as a diverse collection of both benign and malignant pathologies. Concerns raised by the difficulty in accurate diagnosis and local recurrence of benign lesions and by the long-term sequelae of radiotherapy for malignant cranial tumours (marked local growth disturbances, pituitary dysfunction, visual disturbances, late new tumour induction) prompted an evaluation of surgical resection of cranial base tumours in children, with specific regard to safety, efficacy and aesthetic result. Methods : A retrospective review was performed of 10 consecutive children presenting with tumours either arising from or eroding into bone of the cranial base who were managed by surgical resection in a 10-year period from 1986 to 1996. The patients demonstrated a great variation in both presentation and pathology. All underwent surgical resection of tumour with reconstruction where indicated. Results : There were no postoperative complications or mortality. All patients remained clinically free of disease at follow-up, which ranged from 17 months to 9 years (mean 6 years and 4 months). Conclusion : The aggressive surgical resection and craniofacial reconstruction of cranial base tumours in the paediatric population offers a safe and efficacious mode of treatment that obviates problems of diagnosis and local recurrence for benign lesions and of the long-term sequelae of radiotherapy for malignant lesions. 相似文献
95.
用PCR—RFLP和16SrDNA指纹图法分析幽门螺杆菌基因型 总被引:1,自引:1,他引:0
本文建立了PCR-RFLP和16srDNA指纹图法.对19株幽门螺杆菌(HP)进行基因型分析:HP尿素酶C基因的PCR扩增产物.分别用HindⅢ、HaeⅢ、AluⅠ酶切,结果显示:每个酶均将19株HP分为3种RFLP图谱.综合HindⅢ,HaeⅢ和AluⅠ酶切结果,19株HP分为10个酶切带型;PCR扩增HP标准株16SrRNA基因,地高辛标记制备550bp探针,19株HPDNA分别经HaeⅢ和EcoRⅠ酶切、电泳后,通过Southern杂交获16SrDNA指纹图,结果显示:HaeⅢ酶切分为14个杂交带型,EcoRⅠ酶切19株HP杂交带型均不同。本实验表明:上述两种方法重复性好,分群力高,可准确有效地对HP作出鉴定并将其分型。19株HP株间存在基因型差异。 相似文献
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目的:构建含有目的基因kring5的真核植物细胞穿酸表达载体。方法:应用RT-PCR方法,从正常人肝脏组织中获得kringle5基因,测序后,再通过DNA重组技术,将kringle5基因片段克隆到真核植物细胞表达载体pBI121和pCAMBIA3301上。结果:得到的kringle5基因序列测定结果与文献相符,重组载体pB1k5和pC33k5经酶切鉴定正确,含有植物高效表达CaMV35S启动子。结论:重组载体pB1k5和pC33k5不仅可以在大肠杆菌中稳定复制,而且可以在植物细胞中表达。 相似文献
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M Ochsner 《European journal of medicinal chemistry》1996,31(12):939-950
Zinc(II) phthalocyanine is the active component of the liposomal formulation CGP 55847 which showed a high activity in photodynamic therapy in a variety of animal tumours. The photophysical properties of zinc(II) phthalocyanine have been studied in detail and compared to those of Photofrin, the only sensitizing agent approved so far for phase III/IV clinical trials. Since the efficacy of photodynamic therapy intrinsically depends on the spectroscopic features of the sensitizer, quantum chemical methods have proven to be an efficient means for optimizing chemical structures. As will be shown, a simple modification of the time-honoured INDO model of Pople allows a prediction of the singlet and triplet state properties of molecules of the size of zinc(II) phthalocyanine with an rms error of ≤ 1000 cm−1. 相似文献
100.
H. W. Chu S. Balzar J. Y. Westcott J. B. Trudeau Y. Sun D. J. Conrad S. E. Wenzel 《Clinical and experimental allergy》2002,32(11):1558-1565
BACKGROUND: Although 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), a product of 15-lipoxygenase (15-LO), may be involved in mild to moderate asthma, little is known about its potential roles in severe asthma. OBJECTIVES: This study was performed to evaluate 15(S)-HETE levels in bronchoalveolar lavage fluid (BALF) from severe asthmatics with and without airway eosinophils and from the control groups. In addition, 15-LO protein expression was examined in endobronchial biopsy, while its expression and activation were evaluated in BAL cells. RESULTS: While 15(S)-HETE levels in BALF were significantly higher in all severe asthmatics than normal subjects, severe asthmatics with airway eosinophils had the highest levels compared with mild, moderate asthmatics and normal subjects. 15(S)-HETE levels were associated with tissue eosinophil numbers, sub-basement membrane thickness and BALF tissue inhibitor of metalloproteinase-1 levels, and were accompanied by increased 15-LO expression in bronchial epithelium. In addition, activation of 15-LO was suggested by the increased proportion of 15-LO in the cytoplasmic membrane of alveolar macrophages from severe asthmatics. CONCLUSION: The data suggest that severe asthmatics with persistent airway eosinophils manifest high levels of 15(S)-HETE in BALF, which may be associated with airway fibrosis. It is likely that 15-LO expression and activation by airway cells explain the increased 15(S)-HETE levels. 相似文献