葡萄糖酸锌治疗复发性阿弗它口炎疗效初步观察

本文采用锌盐新剂型——葡萄糖酸锌治疗复发性阿弗它口炎。实验组35例,有效率为71.4％,对照组24例,有效率为20.8％,两组间疗效经X~2检验有显著性差异。鉴于目前对复发性阿弗它口炎尚无满意治疗手段,建议将锌剂作为综合治疗辅助手段之一。     

Candida-associated denture stomatitis. Aetiology and management: A review. Part 3. Treatment of oral candidosis

Treatment of oral candidosis with topical antifungal agents such as nystatin and amphotericin B is effective initially. However, medication can produce side effects in some patients and when therapy is stopped the condition can recur. Alternative treatment involving the use of antiseptics and disinfecting agents has been shown to play an important role in the control of dental plaque. The use of sodium hypochlorite as an overnight denture soak has been shown to eliminate denture plaque and recent investigations have demonstrated that microwave irradiation of dentures at a specified setting and exposure time is bactericidal and candidacidal.     

复发性口腔溃疡病人的甲状腺功能检测

①目的探讨甲状腺功能与复发性口腔溃疡病情的关系。②方法将复发性口腔溃疡分为初发期、溃疡期、愈合期和间歇期，以放射免疫分析法分别测定各期血清甲状腺素（ＦＴ３，ＦＴ４）的含量。③结果血清ＦＴ４溃疡期较初发期降低（ｔ＝６．３０４，Ｐ＜０．００１），愈合期开始回升（ｔ＝１．７３５，Ｐ＞０．０５），间歇期进一步回升（ｔ＝３．７３５，Ｐ＜０．００１），但间歇期仍低于初发期（ｔ＝３．５３１，Ｐ＜０．００１）。血清ＦＴ３溃疡期较初发期降低（ｔ＝４．７７６，Ｐ＜０．００１）；愈合期开始回升（ｔ＝２．９００，Ｐ＜０．０５），间歇期进一步回升（ｔ＝３．２１３，Ｐ＜０．００２），间歇期与初发期比较差异无显著性（ｔ＝１．８４５，Ｐ＞０．０５）。④结论复发性口腔溃疡病人甲状腺功能随病情加重而降低，随病情好转而回升。     

Effect of Zendium toothpaste on recurrent aphthous stomatitis

Abstract – A Double-blind clinical trial with cross-over was conducted for a period of 12 months in 25 patients with recurrent aphthous stomatitis (RAS). The effect of the amyloglucosidase and glucoseoxidase containing Zendium toothpaste on the discomfort, number of exacerbations, duration of exacerbation, number of ulcers and number of days with pain caused by RAS was studied. The use of Zendium significantly reduced the sensation of discomfort from RAS as compared to the use of placebo toothpaste (0.025>p>0.01). However, the patients were unable to discriminate significantly between Zendium and placebo when asked to choose one of the toothpastes (0.10>p>0.05) and no significant differences were demonstrated as far as the above mentioned parameters of disease serverity were concerned. Therefore, it is concluded that the reducing effect of Zendium containing amyloglucosidase and glucoseoxidase on RAS is weak as compared to a similar toothpaste without these enzymes.     

Evaluation of a dehydrated test strip, Microstix®-Candida, for detection of Candida-induced denture stomatitis

abstract – The outgrowth of yeasts from the fitting surface of the maxillary denture and the palatal mucosa was estimated in 63 denture wearers by means of smears and by culture on Microstix®-Candida (M–C). There was a significant relationship between the concentration of yeasts as assessed by smears and by M–C. There were confluent spots on M–C, indicating large numbers of yeast cells, in 81 % of 37 denture wearers with a positive microscopic diagnosis for Candida-induced denture stomatitis, whereas there were confluent spots on M–C in only one of 26 denture wearers with a negative microscopic diagnosis for infection. It is concluded that the M–C test system seems to have sufficient diagnostic sensitivity to be an alternative to the smear for establishing the diagnosis of Candida-induced denture stomatitis.     

Efficacy of Topical Antifungal Treatment in Denture Stomatitis

Summary: The report presents results of treatment of 90 patients with denture stomatitis, comprising cases with mycologically controlled yeast-like fungal infections. Pimafucin drops were applied in form of a suspension dropped onto the adjacent denture surface. After a 3-week treatment, 85 per cent of the cases revealed complete recovery, while 11 per cent demonstrated significantly improved clinical state. The results of control mycological examinations after treatment were negative in 80 per cent of the cases. Zusammenfassung: Bei 90 Kranken mit der klinischen Diagnose Stomatitis prothetica und mykologisch nachgewiesener Anwesenheit von hefeähnlichen Pilzen, wurden ?Pimafucin drops” in Suspensionsform angewandt. Das Präparat wurde auf die der Schleimhaut anliegenden Oberfläche der Prothesenplatte aufgetragen. Nach einer 3-Wochen-Kur wurde bei 85% Kranken Heilung und bei weiteren 11% weitgehende klinische Besserung festgestellt. Mykologische Kontrollen waren in 80% der Fälle negativ.     

Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra

Gene transfer to the central nervous system provides powerful methodology for the study of gene function and gene–environment interactions in vivo, in addition to a vehicle for the delivery of therapeutic transgenes for gene therapy. The aim of the present study was to determine patterns of tropism exhibited by pseudotyped lentiviral vectors in the rat substantia nigra, in order to evaluate their utility for gene transfer in experimental models of Parkinson's disease. Isogenic lentiviral vector particles encoding a GFP reporter were pseudotyped with envelope glycoproteins derived from vesicular stomatitis virus (VSV), Mokola virus (MV), lymphocytic choriomeningitis virus (LCMV), or Moloney murine leukemia virus (MuLV). Adult male Lewis rats received unilateral stereotactic infusions of vector into the substantia nigra; three weeks later, patterns of viral transduction were determined by immunohistological detection of GFP. Different pseudotypes gave rise to transgene expression in restricted and distinct cellular populations. VSV and MV pseudotypes transduced midbrain neurons, including a subset of nigral dopaminergic neurons. In contrast, LCMV- and MuLV-pseudotyped lentivirus produced transgene expression exclusively in astrocytes; the restricted transduction of astroglial cells was not explained by the cellular distribution of receptors previously shown to mediate entry of LCMV or MuLV. These data suggest that pseudotyped lentiviral vectors will be useful for experimental gene transfer to the rat substantia nigra. In particular, the availability of neuronal and astrocytic-targeting vectors will allow dissociation of cell autonomous and cell non-autonomous functions of key gene products in vivo.     

Urban legends: recurrent aphthous stomatitis

Oral Diseases (2011) 17 , 755–770 Recurrent aphthous stomatitis (RAS) is the most common idiopathic intraoral ulcerative disease in the USA. Aphthae typically occur in apparently healthy individuals, although an association with certain systemic diseases has been reported. Despite the unclear etiopathogenesis, new drug trials are continuously conducted in an attempt to reduce pain and dysfunction. We investigated four controversial topics: (1) Is complex aphthosis a mild form of Behçet’s disease (BD)? (2) Is periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome a distinct medical entity? (3) Is RAS associated with other systemic diseases [e.g., celiac disease (CD) and B12 deficiency]? (4) Are there any new RAS treatments? Results from extensive literature searches, including a systematic review of RAS trials, suggested the following: (1) Complex aphthosis is not a mild form of BD in North America or Western Europe; (2) Diagnostic criteria for PFAPA have low specificity and the characteristics of the oral ulcers warrant further studies; (3) Oral ulcers may be associated with CD; however, these ulcers may not be RAS; RAS is rarely associated with B12 deficiency; nevertheless, B12 treatment may be beneficial, via mechanisms that warrant further study; (4) Thirty‐three controlled trials published in the past 6 years reported some effectiveness, although potential for bias was high.