Spindle-cell thymic carcinoid occurring in multiple endocrine neoplasia I: Fine-needle aspiration findings in a case

Thymic carcinoid tumors are important to distinguish from thymomas because of their worse prognosis. These rare tumors occasionally occur in the setting of multiple endocrine neoplasia (MEN). A needle biopsy was performed on a 57-yr-old woman with MEN I and a newly-discovered anterior mediastinal mass. Aspiration smears were cellular and contained polygonal-to-spindled cells with high nucleocytoplasmic ratios and evenly-dispersed pattern. Occasional nuclear molding and rosette-like arrangements were present. A synaptophysin immunostain was positive on cell-block preparation. A diagnosis of thymic carcinoid was made. Subsequent excision of the mass confirmed the diagnosis of thymic carcinoid. Thymic carcinoids are cytologically similar to carcinoid tumors elsewhere. They should be distinguished from epithelial thymoma and substernal medullary carcinoma of the thyroid. Diagn Cytopathol 1996;15:439–441. © 1996 Wiley-Liss, Inc.     

Endometriosis of sigmoid colon mimicking malignant tumor diagnosed by intraoperative imprint cytology

A case of endometriosis of the sigmoid colon on imprint cytology from an intraoperative biopsy is discussed. Cytologic specimens showed sheets or tubular epithelial clusters and stromal fragments. The epithelial cell nuclei were small and round to ovoid with finely granular chromatin and inconspicuous nucleoli. The background showed a few scattered spindle-type stromal cells without pigment-laden histiocytes. A definitive diagnosis of endometriosis can be based on cytology, provided that the cytologic findings are interpreted in the appropriate clinical context.     

细针穿刺细胞学及细胞块技术在颈部肿大淋巴结诊断的意义

目的探讨细针穿刺细胞学联合细胞块技术对于明确诊断颈部肿大淋巴结的意义。方法选择颈部肿大淋巴结病例109例行细针穿刺涂片并制备细胞块切片,必要时行免疫细胞化学染色检测,比较单纯常规穿刺涂片与涂片联合细胞块切片检查结果,分析相应技术诊断的准确性。结果109例中,单纯常规细针穿刺涂片与最终诊断的符合率仅为54．1％,联合细胞块切片符合率为78．9％,免疫细胞化学染色检查后符合率则达到95．4％。结论常规细针穿刺涂片联合细胞块切片及免疫细胞化学染色对于颈部肿大淋巴结诊断有较高的应用价值,但对于少数差分化肿瘤及恶性淋巴瘤的诊断存在一定局限性。     

细胞印片在肿瘤手术中的诊断价值

[目的 ]探讨细胞印片在肿瘤手术中的诊断价值 .[方法 ]对 12 4例术中送检肿瘤标本进行细胞印片诊断 ,并与冷冻切片及术后石蜡切片诊断进行比较 .[结果 ]与常规石蜡切片诊断比较 ,术中细胞印片诊断的准确率为 96 0 % ,冷冻切片的准确率为 98 4 % .[结论 ]术中细胞印片诊断肿瘤的准确率与冷冻切片相似 ,是一种简便、快速及可靠的术中诊断肿瘤的方法 .     

肿瘤脱落细胞中端粒酶活性检测的意义

寻求一种检测微量肿瘤细胞的方法。方法采用ＰＣＲ－ＥＬＩＳＡ法检测宫颈，尿液，腹水中脱落细胞的端粒酶活性。结果宫颈癌患者宫颈脱落细胞中端粒酶活性表达阳性率为９５．２４％；尿路上皮性癌尿液脱落细胞者为８８．１％，卵巢癌性腹水中脱细胞者为１４．３％。     

HR-HPV检测联合宫颈液基细胞学及经阴道镜活检诊断宫颈病变

目的 评估高危型人乳头状瘤病毒(HR-HPV)检测、液基细胞学(LCT)及阴道镜下组织活检联合应用在宫颈病变诊断中的作用及意义.方法 对2009年1月至2011年10月在广州医学院第二附属医院妇科门诊LCT检查异常的601例患者行HR-HPV检测,与经阴道镜活检结果比较,评价HR-HPV联合LCT诊断宫颈病变的作用.结果 LCT检测细胞学异常者HR-HPV阳性感染率为67.2％(404/601),诊断意义不明的非典型鳞状上皮细胞(ASC-US)、低度鳞状上皮内病变(LSIL)、非典型鳞状上皮细胞不除外高级别鳞状上皮内病变(ASC-H)、高度鳞状上皮内病变(HSIL)和侵袭性鳞状细胞癌(CA)组的感染率分别为45.5％ 、66.2％、74.4％、89.1％和100.0％,差异有统计学意义(P＜0.05).LCT与HR-HPV联合检测诊断宫颈上皮内瘤样变(CIN)及以上宫颈病变的敏感性为86.1％,高于LCT(77.1％)和HR-HPV(72.0％)检测,差异有统计学意义(P＜0.05);假阴性率为13.9％,低于LCT(22.9％)和HR-HPV(38.0％)检测,差异有统计学意义(P＜0.05).在601例LCT异常的患者中,LCT中＜LSIL和阴道镜活检＜CIN结果的一致性为50.8％(102/201),LCT中≥LSIL和阴道镜活检≥CIN结果的一致性为83.3％(333/400),两者均为CA的一致性为88.0％(24/25).201例ASC患者中,慢性炎症或正常102例(50.7％)、CIN Ⅰ 22例(11.0％)、CINⅡ40例(19.9％)、CINⅢ34例(16.9％)和鳞癌2例(1.0％).HR-HPV检测阳性率为59.2％(119/201),其对CIN及以上宫颈病变者检出的敏感度为71.7％(71/99)、特异度为53.0％(54/102)、准确率为64.7％.结论 宫颈病变的发生与HR-HPV感染密切相关,LCT与HR-HPV联合检测对宫颈病变具有较好的检出效果,阴道镜下活检可以大大提高宫颈病变的诊断率.     

液基细胞学检查在诊断宫颈病变中的临床价值

[目的]探讨宫颈液基细胞学检查(TCT)对宫颈病变的诊断价值及意义.[方法]回顾性分析中国医科大学附属盛京医院门诊57 784例TCT筛查结果.细胞学诊断采用TBS(2001)分级报告系统,阳性诊断包括意义不明确的不典型鳞状细胞(ASC-US)及以上病变,其中阳性者554例行阴道镜下宫颈活组织检查,其中317例同时又进...     

Fine needle aspiration biopsy in the diagnosis of intraocular cancer. Cytologic-histologic correlations

Fine needle aspiration biopsy was used as an investigational procedure in the evaluation of 71 eyes harboring a suspected intraocular malignancy between January 8, 1981, and January 21, 1983. Twenty-seven of these 71 biopsies were performed prior to any treatment as a diagnostic procedure and the others were performed following enucleation or tumor excision to provide specimens for cytologic-histologic correlation. The histologic findings confirmed the cytologic diagnosis of malignancy or benignancy in 94.3% of the 53 cases in which a corresponding tissue specimen was available for histologic evaluation. None of the eight eyes with a cytologically confirmed diagnosis of malignancy that were managed conservatively following the biopsy has experienced visual loss attributable to the biopsy. There have been no instances of documented needle tract seeding by tumor cells or orbital tumor recurrence to date in the 27 cases in which diagnostic fine needle aspiration biopsy had been performed prior to treatment.     

间接免疫荧光技术对毛细支气管炎合胞病毒病原快速诊断的研究

应用间接免疫荧光技术对50例毛细支气管炎患儿鼻咽分泌物脱落细胞进行合胞病毒抗原检查,与病毒分离和/或补体结合试验比较,敏感性为74.2％,特异性为68.4％。间接免疫荧光技术敏感、特异、快速、简便,能够为RSV感染的早期快速诊断提供依据,具有临床应用价值。     

针刺快速细胞学诊断在肺及纵隔肿瘤手术中的应用

目的：探讨细针穿刺细胞学诊断在肺及纵隔肿瘤手术中的应用价值。方法：对79例肺部肿块、12例纵隔肿瘤术中应用细针穿刺细胞学诊断，并与术后病理结果对照。结果：肺部肿块细胞学诊断准确率为97．5％（77／79），细胞类型诊断准确率为93％（55／59），纵隔肿瘤细胞学诊断准确率为100％。结论：对未定性的肺及纵隔肿瘤本操作具有容易、安全，快速和无非发症的优点，可避免盲目进行扩大肺组织切除，尽最大限度保留健康肺组织。