2型糖尿病视网膜病变患者血清脂联素水平的研究

目的 为观察血清脂联素水平的变化与2型糖尿病合并视网膜病变(DR)各期的关系.方法 采用ELISA法对113例2型糖尿病患者血清脂联素水平进行检测,其中2型糖尿病无DR患者30例(DM组)、2型糖尿病合并DR背景型患者45例(BDR组)、2型糖尿病合并DR增殖型患者38例(PDR组)和健康对照30例(NC组).结果 (1)DM组血清脂联素水平与NC组比较差异有统计学意义(P＜0.05);BDR组血清脂联素水平与DM组、NC组比较差异均有统计学意义(P＜0.05或P＜0.01);PDR组血清脂联素水平与BDR组、DM组、NC组比较差异均有统计学意义(P＜0.05或P＜0.01).(2)相关分析发现,2型糖尿病患者血清脂联素水平与收缩压、糖化血红蛋白、TG、TC、LDL-C成显著负相关,而与HDL-C成显著正相关.结论 2型糖尿病患者血清脂联素水平明显降低, 2型糖尿病合并DR后血清脂联素水平更低.脂联素可作为判断2型糖尿病合并DR损害程度的指标.     

Acupuncture effects on in-vitro fertilization pregnancy outcomes: A meta-analysis

BackgroundThe effects of acupuncture on in-vitro fertilization outcomes remain controversial. This study aimed to perform a meta-analysis to assess the effectiveness of acupuncture as an adjuvant therapy to embryo transfer compared to sham-controls or no adjuvant therapy controls on improving pregnancy outcomes in women undergoing in-vitro fertilization.MethodsA systematic literature search up to January 2021 was performed and 29 studies included 6623 individuals undergoing in-vitro fertilization at the baseline of the study; 3091 of them were using acupuncture as an adjuvant therapy to embryo transfer, 1559 of them were using sham-controls, and 1441 of them were using no adjuvant therapy controls. They reported a comparison between the effectiveness of acupuncture as an adjuvant therapy to embryo transfer compared to sham-controls or no adjuvant therapy controls on improving pregnancy outcomes in women undergoing in-vitro fertilization. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated assessing the effectiveness of acupuncture as an adjuvant therapy to embryo transfer compared to sham-controls or no adjuvant therapy controls using the dichotomous method with a random or fixed-effect model.ResultsSignificantly higher outcomes with acupuncture were observed in biochemical pregnancy (OR, 1.98; 95% CI, 1.55–2.53, p < 0.001); clinical pregnancy (OR, 1.70; 95% CI, 1.46–1.98, p < 0.001); ongoing pregnancy (OR, 1.78; 95% CI, 1.41–2.26, p < 0.001); and live birth (OR, 1.58; 95% CI, 1.15–2.18, p = 0.005) compared to no adjuvant therapy controls. However, no significant difference were found between acupuncture and no adjuvant therapy controls in miscarriage (OR, 0.96; 95% CI, 0.48–1.92, p = 0.91).No significant difference was observed with acupuncture in biochemical pregnancy (OR, 1.16; 95% CI, 0.65–2.08, p = 0.62); clinical pregnancy (OR, 1.13; 95% CI, 0.83–1.54, p = 0.43); ongoing pregnancy (OR, 1.04; 95% CI, 0.66–1.62, p = 0.87); live birth (OR, 1.02; 95% CI, 0.73–1.42, p = 0.90), and miscarriage (OR, 1.16; 95% CI, 0.86–1.55, p = 0.34) compared to sham-controls.ConclusionsUsing acupuncture as an adjuvant therapy to embryo transfer may improve the biochemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth outcomes compared to no adjuvant therapy controls. However, no significant difference was found between acupuncture as an adjuvant therapy to embryo transfer and sham-controls in any of the measured outcomes. This relationship forces us to recommend the use of acupuncture as adjuvant therapy in women undergoing in-vitro fertilization and inquire further studies comparing acupuncture and sham-controls to reach the best procedure.     

Topical Calendula officinalis L. inhibits inflammatory pain through antioxidant,anti-inflammatory and peripheral opioid mechanisms

Objective: The present study evaluated the antinociceptive activity of Calendula officinalis L.(Ca) cream on inflammatory hypernociception.Methods: Creams with different Ca concentrations were tested for their ability to ameliorate pain-related behavior and edema in rats using formalin test, carrageenan(Cg)-induced acute inflammation model,bradykinin(BK)-induced acute inflammation model, and complete Freund’s adjuvant(CFA)-induced chronic inflammation model. Using the formalin test, we also exam...     

基于CiteSpace近5年重复经颅磁刺激文献计量学及可视化分析

目的:通过对国内外近5年的重复经颅磁刺激(rTMS)相关研究进行文献计量学及可视化分析,概述其研究现状、热点以及热点演变趋势。方法:检索中国知网(CNKI)和Web of Science(WoS)数据库核心集2015—2019年rTMS的相关文献。运用CiteSpace软件对作者、国家和机构、关键词进行共现分析,对关键词进行聚类分析、时间演化分析、突显词(Burst)分析,同时绘制相应知识图谱。结果:CNKI检索共获得996篇文献,张通为高产作者,机构发文数最多的是首都医科大学康复医学院;WoS检索获得2086篇文献,JONATHAN DOWNAR为高产作者,国家发文数最多的是美国,中心度较高的国家是葡萄牙。国内外在rTMS领域的研究热点主要集中在对抑郁症、精神分裂症等精神类疾病的治疗,对脑卒中后遗症认知、运动功能障碍的恢复研究以及对大脑皮质各功能区的作用机制探索。预测该领域在未来一段时间内将继续深入rTMS对脑区功能影响的研究,并进一步揭示其作用机制。结论:运用CiteSpace对国内外近5年rTMS研究文献进行可视化分析,较为直观地反映了rTMS的研究现状、热点及热点演变趋势,为rTMS研究的选题、发展方向等提供一定参考。     

消脂汤对高脂血症大鼠降脂作用的实验研究

目的：目的：探讨消脂汤对高脂高糖高胆固醇饮食诱导的高脂血症大鼠的降脂作用。方法：用高脂高糖高胆固醇饲料饲养大鼠制备高脂血症模型,造模结束后取目内眦血测定血脂水平评价模型是否成功。成模动物分成中药组（高、中、低剂量组）、阳性对照组和模型组,中药组和阳性对照组分别给予消脂汤高、中、低剂量和立普妥灌胃治疗30d,同时给予高脂饲料喂养。测定各组实验大鼠血清TG、TC、HDL—TC、LDL—TC含量;取肝脏对其脂肪变性程度进行积分。结果：与模型组比较,中药高剂量组、阳性对照组血清TC水平有显著降低（P〈0．01）,中药高、中剂量组和阳性对照组血清LDL—TC水平有显著降低（P〈0．01或P〈0．05）。结论：高脂高糖高胆固醇饮食能成功制备高脂血症模型;消脂汤能有效降低血脂。     

MRI在肛瘘疾病的术前诊断及评估

目的 探讨MRI对肛瘘的术前诊断价值。方法 收集2017年3月~2018年10月我院收治的肛瘘患者60例,常规进行盆腔MRI检查后2周内行手术切除,分析术前MRI显示肛瘘瘘管、外口、内口和肛提肌受累情况,以手术所见为标准,分析MRI对肛瘘显示准确率。结果 术前MRI显示肛瘘瘘管、外口及内口、肛提肌受累与手术结果比较,差异无统计学意义（P＞0.05）。瘘管在MRI表现为T1WI低信号,T2WI压脂序列为高信号,DWI序列为高信号;内口T2WI压脂序列为点状高信号;外口T1WI压脂序列为低信号,T2WI压脂序列为高信号。结论 MRI对肛瘘瘘管、内口、外口及肛瘘累及范围显示均较佳,在肛瘘术前诊断及评估中具有较大的价值。     

基于数据挖掘的钟以泽教授治疗银屑病处方组方规律分析

目的:探讨钟以泽教授治疗银屑病的用药规律和临床经验。方法:收集整理钟以泽教授银屑病的门诊处方104张,构建处方数据库,应用相关软件,分析处方中药物的关联性。结果:统计出钟以泽教授治疗银屑病用药中单味药用药≥10次的排名,2味药使用频次≥30次的药物排名,3味药联合使用频次≥30次的药物排名,以及补阴药、活血祛瘀药的使用及联用情况。结论:2味药及3味药的联用对于组方中加减用药有较好的参考价值;处方均以清热凉血、清热解毒作为君药的治则,而以补阴、活血祛瘀为臣药的治则,其余为加减使用。     

两种不同古典针刺手法的实时中枢整合特征研究:一项基于近红外光谱成像技术的随机交叉试验研究方案（英文）

Background:Reinforcing-reducing manipulations are a crucial part of acupuncture therapy.The reinforcing manipulation with heat sensation(RMHS) and the reducing manipulation by inducing cool sensation(RMCS) are two representative methods of reinforcing-reducing manipulations.This trial aims to investigate the characteristic of cerebral responses to these two typical acupuncture manipulations.Methods:A total of 35 healthy participants will be included and receive acupuncture stimulation with RMHS ...     

Improved symptoms of complex regional pain syndrome after novel lymphatic treatment and interdisciplinary pain management

IntroductionComplex regional pain syndrome (CRPS) is a pain syndrome with no singular mechanism and no specific cure. The aim of this case report is to study the impact of Lymphatic Enhancement Technology (LET) treatment on CRPS-related symptoms.MethodsA 51 year-old female presented with a chief complaint of severe, refractory ankle pain and CRPS related to a tibial and fibular fracture sustained three years earlier. The patient completed twelve cognitive behavioral therapy sessions over a 4-week period, and eleven physical therapy sessions over a four-month period, six of which utilized LET.ResultsPain and swelling were largely unchanged with interdisciplinary treatment before the introduction of LET. A within-session change of 37.5% in pain intensity and 87.5% in ankle girth was observed immediately after the first application of LET. Three months after beginning LET treatment, the patient maintained a 43.8% improvement in pain intensity and 100% improvement in measurements of lower extremity girth and ankle range of motion. No side effects or adverse events were associated with the LET treatment.ConclusionSwelling, pain, and mobility loss are common symptoms and features of CRPS. LET is a novel, non-invasive treatment that appears to be quite safe and effective for improving pain, swelling, and mobility loss related to CRPS.