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Zhiqi Song Chun‐Di He Jing Liu Changkai Sun Ping Lu Lili Li Lili Gao Yi Zhang Yanni Xu Lujuan Shan Yuejian Liu Wei Zou Yuan Zhang Haiqin Gao Wenting Gao 《Experimental dermatology》2012,21(12):926-931
Glutamate is an excitatory neurotransmitter that has been shown to regulate the proliferation, migration and survival of neuronal progenitors in the central nervous system through its action on metabotropic and ionotropic glutamate receptors (GluRs). Antagonists of ionotropic GluRs have been shown to cause a rapid and reversible change in melanocyte dendritic morphology, which is associated with the disorganization of actin and tubulin microfilaments in the cytoskeleton. Intracellular expression of microtubule‐associated protein (MAP) 2a affects the assembly, stabilization and bundling of microtubules in melanoma cells; stimulates the development of dendrites; and suppresses melanoma cell migration and invasion. In this study, we investigated the relationship between glutamate‐mediated signalling and microtubules, cell dendritic morphology and melanoma cell motility. We found that metabotropic GluR1 and N‐methyl‐d ‐aspartate receptor antagonists increased dendritic branching and inhibited the motility, migration and proliferation of melanoma cells. We also demonstrated that the invasion and motility of melanoma cells are significantly inhibited by the combination of increased expression of MAP2a and either metabotropic GluR1 or N‐methyl‐d ‐aspartate receptor antagonists. Moreover, the blockade of glutamate receptors inhibited melanoma growth in vivo. Collectively, these results demonstrate the importance of glutamate signalling in human melanoma and suggest that the blockade of glutamate receptors is a promising novel therapy for treating melanoma. 相似文献
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目的探讨立体定向微创手术治疗高血压脑出血的临床疗效.方法回顾性分析2007年1月至2008年10月在延安大学附属医院神经外科高血压性脑出血的89例患者,随机分为微创组42例和对照组47例,微创组行微创手术加药物治疗,对照组是内科药物保守治疗.结果微创组总有效率100%,对照组总有效率76.6%,微创组的临床疗效大于对照组,2组比较差异有统计学意义(P<0.01).结论微创术治疗高血压性脑出血疗效明显优于药物保守治疗,在临床上值得进一步的推广和应用. 相似文献
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心血管疾病严重威胁人类健康,具有高发病率、高致死率和高致残率的特点。近年来研究发现,补体因子H(complement factor H,CFH)是补体系统和炎症反应中非常重要的负性调节因子。CFH的减少或缺如可使补体旁路途径持续激活及介导的炎症反应增强,导致血管内皮细胞和心肌细胞等损伤。CFH在心血管疾病的发病中扮演着重要的角色并参与了其病理生理学机制。现系统综述CFH在心血管疾病发病中的作用及机制。 相似文献
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Zong-Yang Li Qing-Zhong Li Guo-Xu Ma Lei Chen Ce Zhang Bao-dong Chen 《Journal of Asian natural products research》2017,19(5):423-435
Plant-derived natural products have been the highly significant sources of novel antitumor agents. The cassane-type diterpenes of genus Caesalpinia have been reported to bear antiproliferative activities toward different types of cancer cells. In this study, we evaluated the antineoplasmic activities of 16 natural origin cassane-type diterpenes isolated from the CHCl3 extract of the seeds of C. minax in pituitary adenomas cells and identified caesalpin G (CAG) showed the strongest cytotoxicity. Moreover, we further investigated the structure–activity relationship and molecular mechanism of these derivatives systematically. The results confirmed the unsaturated lactone-type ring, hydroxyl at C-7, and alkenyl at C-11 or C-14 functionality as critical for anticancer activity in this family of natural products. In addition, the mechanism experiments also demonstrated unfolded protein response and ER stress and Wnt/β-catenin pathway were involved in the CAG-induced apoptosis. 相似文献
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