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排序方式: 共有142条查询结果,搜索用时 31 毫秒
1.
目的 了解山东省青岛市5类公共场所和工作场所室内烟草烟雾PM 2.5浓度,为青岛市控烟立法提供基线数据。方法 2012年6月-9月,随机选取餐馆、宾馆、政府机关、医院和学校室内共40家80个监测点、室外40个监测点,检测室内外空气PM 2.5浓度并进行分析。结果 青岛市各类场所室内PM 2.5均值为70.0μg/m3(9.1~228.0μg/m3)。学校PM 2.5浓度(51.2μg/m3)最低,餐馆PM 2.5最高(97.3μg/m3);餐馆和宾馆室内log PM 2.5分别为(1.93±0.60)和(1.86±0.51)μg/m3,均高于室外(P<0.05);医院、学校和政府机关室内外PM 2.5差异无统计学意义(P>0.05)。餐馆和宾馆室内PM 2.5均高于其他场所(P<0.05);学校与医院室内PM 2.5比较有明显差异(P<0.05)。结论 餐馆和宾馆室内环境烟草烟雾污染较严重,创建无烟学校和无烟医院取得一定成果。 相似文献
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Jian-Wei Liu Hong-Ling Wen Li-Zhu Fang Zhen-Tang Zhang Shu-Ting He Zai-Feng Xue Dong-Qiang Ma Xiao-Shuang Zhang Tao Wang Hao Yu Yan Zhang Li Zhao Xue-jie Yu 《Emerging infectious diseases》2014,20(12):2126-2128
To evaluate the role of small mammals as hosts of severe fever with thrombocytopenia syndrome virus (SFTSV), we tested serum samples from rodents and shrews in China, collected in 2013. SFTSV antibodies and RNA were detected, suggesting that rodents and shrews might be hosts for SFTSV. 相似文献
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《Nutrition, metabolism, and cardiovascular diseases : NMCD》2022,32(12):2877-2882
Background and aimsType 2 diabetes mellitus (T2DM) has high risk of developing cardiac dysfunction, increasing of either cardiovascular death or hospitalization for heart failure. MicroRNAs (miRNA) affect cardiac function of T2DM. The aim of this study was to investigate the relationships between five miRNA single nucleotide polymorphisms (SNP) and diastolic and systolic function of T2DM.Methods and resultsThree hundred untreated T2DM subjects were included. Each subject underwent SNP genotyping, conventional echocardiography, tissue doppler imaging, and speckle tracking imaging. The effects of miRNA SNPs on diastolic and systolic function were evaluated. The diastolic function of T2DM subjects with miR-133a-1-rs8089787 wild genotype or let-7f-rs10877887 variant genotype was lower than those with miR-133a-1-rs8089787 variant genotype or let-7f-rs10877887 wild genotype, manifesting as higher left atrial volume index, lower mean E′, and higher E/E’ (P < 0.05). There were no significant effects of miR-133a-2-rs13040413, let-7a-1-rs13293512 and miR-27a-rs895819 on the diastolic function of T2DM subjects (P > 0.05). These five miRNA SNPs had no effect on the systolic function of T2DM subjects (P > 0.05).ConclusionsMiRNA-133a-1-rs8089787 and let-7f-rs10877887 were associated with impaired cardiac diastolic function in T2DM. The findings may be a promising therapeutic targets for preventing diastolic dysfunction in T2DM. 相似文献
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《Nutrition, metabolism, and cardiovascular diseases : NMCD》2022,32(12):2822-2829
Background and aimsAssociations of alanine aminotransferase (ALT) and serum uric acid (SUA) with metabolic syndrome (MetS) remain controversial. We aimed to explore individual and combined effects of ALT and SUA on MetS in community residents.Methods and resultsA population-based cross-sectional survey involving randomly selected Chinese adults aged 35–74 years was conducted in 2009 in Qingdao, China, and 4642 participants were included in the current study. Based on a combination of SUA and ALT levels in the tertile, subjects were grouped into Group 1-9. The individual and combined relations of SUA and ALT to MetS were analyzed by logistic regression models. The prevalence of MetS was 28.50% in males and 22.30% in females. ALT and SUA were independently associated with MetS and ORs (95% CIs) were 1.55 (1.42–1.70) and 1.92 (1.72–2.14), respectively, after adjusting for potential confounders. With the elevation of ALT and SUA levels, the risk of developing MetS increased. Compared to Group 1, ORs (95% CIs) of combined ALT and SUA for MetS were 2.21 (1.70–2.88), 4.02 (3.10–5.21), 2.19 (1.62–2.97), 2.53 (1.91–3.34), 4.69 (3.60–6.12), 1.76 (1.17–2.64), 3.65 (2.63–5.06) and 7.15 (5.41–9.46) in Group 2–9, respectively.ConclusionsALT and SUA were both related to MetS independently. Combined elevation of ALT and SUA levels could increase the risk of MetS and its components than an elevation in SUA and ALT alone. Therefore, measures should be taken to lower SUA and ALT levels to reduce the risk of having MetS. 相似文献
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缪珂 曹卫华 吕筠 余灿清 王胜锋 黄涛 孙点剑一 廖春晓 庞元捷 逄增昌 俞敏 汪华 吴先萍 董忠 吴凡 江国虹 王晓节 刘彧 邓健 陆林 高文静 李立明 《中华流行病学杂志》2023,44(4):544-551
目的描述中国双生子登记系统(CNTR)成年双生子高脂血症的分布特征, 初步探索遗传和环境因素对高脂血症的影响。方法研究对象来自CNTR在全国11个项目地区募集的双生子, 纳入成年且具有高脂血症信息的69 130名(34 565对)双生子进行分析。采用随机效应模型描述高脂血症的人群、地区分布特征。分别计算不同卵型双生子的高脂血症同病率, 估算遗传度。结果研究对象年龄为(34.2±12.4)岁。双生子人群高脂血症患病率为1.3%(895/69 130)。男性、年长、城镇、已婚、大专及以上文化程度、超重、肥胖、体力活动不足、当前吸烟和曾经吸烟、当前饮酒和曾经饮酒人群中高脂血症患病率较高。双生子对内分析发现, 同卵双生子高脂血症同病率为29.1%(118/405), 高于异卵双生子的18.1%(57/315), 差异有统计学意义(P<0.05)。在不同年龄、地区及性别分层中, 同卵双生子同病率仍呈现高于异卵双生子的趋势。进一步同性别双生子对内分析发现, 在北方组和女性组中, 高脂血症遗传度分别为13.04%(95%CI:2.61%~23.47%)、18.59%(95%CI:4.43%~3... 相似文献
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[目的]为深入了解我市MSM活跃人群的艾滋病知识知效率和高危行为特点及HIV感染状况,进一步探索对该人群的有效干预措施,降低艾滋病感染率。[方法]选择在青岛市居住6个月以上经常在青岛市MSM活跃的酒吧、公园、公厕等场所活动的曾经与另一位男性发生过性行为(包括口交、肛交)的18岁及以上的MSM,通过宣传教育、外展服务、同伴教育等对其开展知识宣传和行为干预,分别于干预前后,对他们进行基本人口学特征、艾滋病相关知识知晓率和行为特点调查。于干预前调查的同时对MSM进行HIV感染状况调查。结果采用SPSS分析软件进行统计分析。[结果]干预前调查216人,干预后调查199人。干预前后被调查人员的人口学特征基本一致。年龄21~30岁为主,干预前后分别占68.06%、66.33%;大专以上学历占多数(分别占67.13%和65.83%),性取向以同性恋者较多(分别占56.94%和59.80%),多数人未婚(分别占71.30%和69.85%);第一次性行为多在20岁左右[干预前后平均年龄分别为(20.46±4.27)岁和(20.52±3.05)岁],第一次性行为对象以男性者居多(73.15%、79.90%)。存在多性伴及买性或卖性现象,也有相当比例的MSM同时与女性保持性关系(25.46%、20.10%)。目标人群干预前艾滋病相关知识总的知晓率为59.05%,近6个月肛交安全套使用率为45.27%,近6个月口交安全套使用率为13.40%,与女性发生性行为安全套使用率为32.73%;干预后艾滋病相关知识知晓率为87.02%,近6个月肛交安全套使用率为63.83%,近6个月口交安全套使用率为31.58%,与女性发生性行为安全套使用率为57.5%。干预活动取得显著成效,尤其是干预后目标人群的不传播途径及预防措施知识知晓率及肛交安全套使用率有了较大幅度提高。HIV的 相似文献
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目的应用Meta分析方法探讨中国人群HLA—DR基因多态性与肺结核易感性的关系。方法通过全面检索查找已发表的有关中国人群肺结核与HLA—DR基因关联性的文献。以肺结核组和健康对照组的HLA—DR等位基因型频数分布的比值比为统计量,采用RevMan5.0.13进行Meta分析。结果符合纳入标准的文献共7篇。Meta分析及敏感性分析发现,病例组和对照组DR4、DR16、DRBI*15和DRBI*13.2的合并比值比及其95%可信区间分别为1.64(1.08,2.50)、2.08(1.32,3.28)、2.94(1.34,6.49)和0.32(0.14,0.72)。结论DR4和DR16可能是南方汉族人群的易感基因;DRBI*15可能是北方汉族人群肺结核的易感基因,DRBI*13.2可能是其保护基因。 相似文献
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《Nutrition, metabolism, and cardiovascular diseases : NMCD》2023,33(4):758-769
Background and aimsThe associations between genetic factors and waist circumference (WC) with stroke risk have been evaluated in Western studies. However, evidence of this association has rarely been reported in the Chinese population. This study aimed to evaluate the association between WC and family history of stroke (FHS) with ischemic stroke (IS) risk among Chinese adults and to further explore the potential interaction of these associations.Methods and resultsThe China Kadoorie Biobank (CKB) study recruited 35,508 participants aged 30–79 years from the Qingdao urban area during 2004–2008. A total of 33,355 participants were included in study. Cox regression analysis was used to estimate the multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the independent and interactional associations between FHS and WC and IS risk. Participants with FHS had a 29% (HR = 1.29, 95% CI: 1.12–1.50) higher IS risk than those without FHS. Participants with excessive WC (85 cm for males and 80 cm for females) had a 78% (HR = 1.78, 95% CI: 1.51–2.10) higher IS risk than those with normal WC. The combined effect of FHS and excessive WC on IS was statistically significant (HR = 2.29, 95% CI: 1.84–2.86). The present study further found statistically significant multiplicative interactions of FHS and WC with IS risk (P interaction < 0.001).ConclusionThe present study indicated that FHS and WC were significantly associated with an increased risk of IS. The association between FHS and IS was associated with excessive WC. 相似文献