彩色多普勒超声在子宫动脉栓塞术治疗子宫瘢痕妊娠疗效监测中的应用

目的探讨彩色多普勒超声在子宫动脉栓塞术(UAE)治疗子宫瘢痕妊娠(CSP)疗效监测与评价中的应用价值。方法回顾性分析96例CSP患者UAE治疗前及治疗后的超声表现及相关临床资料,并进行统计学分析。结果 96例CSP患者中,孕囊型58例,团块型38例。孕囊型CSP患者UAE并清宫后孕囊均被清除。团块型CSP患者UAE并清宫后24~48h团块直径较UAE术前及UAE术后24~48h减小(P均0.001)。孕囊型与团块型CSP患者间,UAE术前、UAE术后24~48h及UAE并清宫后24~48h病灶周边血流信号分级差异均无统计学意义(P均0.05)。两种类型CSP患者UAE术后24~48h、UAE并清宫后24~48h病灶周边血流信号分级均较UAE术前明显减低(P均0.001)。孕囊型与团块型CSP患者间,UAE术前及UAE术后24~48h子宫瘢痕厚度差异均无统计学意义(P均0.05)。UAE并清宫后24~48h孕囊型CSP患者子宫瘢痕厚度高于团块型(P0.001)。孕囊型CSP患者UAE并清宫后24~48h子宫瘢痕厚度高于UAE术前及UAE术后24~48h(P均0.001)。团块型CSP患者UAE并清宫后24~48h子宫瘢痕厚度高于UAE术前(P=0.037),与UAE术后24~48h差异无统计学意义(P=0.112)。孕囊型CSP患者术中出血量、住院时间、血清人绒毛膜促性腺激素(β-HCG)降至正常的时间及术后阴道流血时间均少于团块型(P均0.001)。结论通过彩色多普勒超声可有效监测UAE治疗CSP的疗效,UAE对不同类型CSP的疗效有所不同,孕囊型CSP患者疗效优于团块型。     

诱导痰细胞分类在嗜酸细胞性支气管炎诊断和治疗中的应用

目的探索诱导痰细胞分类在嗜酸细胞性支气管炎(EB)诊断和治疗中的作用。 方法回顾性分析我院门诊239例慢性咳嗽患者,依据慢性咳嗽中诊断标准,分为非EB组和EB组,分析两组诱导痰中细胞分类情况;同时给予EB患者进行8周治疗,观察经治疗后诱导痰中各细胞分类的改变情况。 结果239例慢性咳嗽患者中,非EB患者216例,占90.7%,EB患者23例,占9.3%,两组中共有121例(50.6%)患者诱导痰中嗜酸细胞百分比升高;非EB患者组细胞总计数为(4.83±2.61)×10⁶个/g、嗜酸细胞比例为(4.56±10.07)%、中性粒细胞比例为(50.32±26.12)%、淋巴细胞比例为(5.14±7.27)%、单核巨噬细胞比例为(40.30±16.70)%,EB患者组痰中细胞总计数为(5.46±3.07)×10⁶个/g、嗜酸细胞比例为(13.85±1 2.23)、中性粒细胞比例为(46.16±16.89)、淋巴细胞比例为(4.83±2.98)、单核巨噬细胞比例为(35.91±16.35),两组间EB组嗜酸细胞比例有显著的增多(P<0.05),在性别、年龄以及其余细胞成分差异无统计学意义(P>0.05);EB患者组经治疗后,痰中细胞总计数为(4.07±3.89)×10⁶个/g、嗜酸细胞比例为(2.52±3.80)%、中性粒细胞比例为(54.18±17.97)%、淋巴细胞比例为(5.59±4.33)%、单核巨噬细胞比例为(38.32±17.23)%,嗜酸细胞较治疗前有显著减少(P<0.05),其余细胞改变无显著差异(P>0.05)。 结论诱导痰细胞分类检查是诊断EB的重要方法,在其诊断和治疗过程中有着重要的指导作用,可作为EB治疗过程的监测指标。     

支气管扩张剂雾化吸入在支气管镜检查患者肺功能保护中的临床应用

目的探索操作前应用短效支气管扩张剂雾化吸入对接受支气管镜检查的患者肺功能的保护作用。 方法分析我院2019年2月至2019年4月收治的拟行气管镜检查的患者36例,随机分为对照组和观察组：对照组患者接受操作前常规的丁卡因压缩空气雾化机雾化吸入,观察组患者接受操作前丁卡因联合短效支气管扩张剂压缩空气雾化机雾化吸入;比较两组患者支气管镜检查前、后生命征、氧饱和度、肺功能指标变化。 结果操作前两组患者生命征、氧饱和度、通气功能指标等均无统计学差异,支气管镜检查后患者的收缩压、氧饱和度、通气功能指标等较操作前明显变化,而接受操作前短效支气管扩张剂雾化吸入的患者通气功能、氧饱和度等指标明显优于对照组患者,而且心率更加稳定。 结论支气管镜操作可导致操作后患者通气功能指标下降,支气管镜操作前应用短效支气管扩张剂雾化吸入治疗可有效保护患者肺功能,提高了围操作期的安全性。     

Role of Angptl4 in vascular permeability and inflammation

Background

Angptl4 is a secreted protein involved in the regulation of vascular permeability, angiogenesis, and inflammatory responses in different kinds of tissues. Increases of vascular permeability and abnormality changes in angiogenesis contribute to the pathogenesis of tumor metastasis, ischemic-reperfusion injury. Inflammatory response associated with Angptl4 also leads to minimal change glomerulonephritis, wound healing. However, the role of Angptl4 in vascular permeability, angiogenesis, and inflammation is controversy. Hence, an underlying mechanism of Angptl4 in different kind of tissues needs to be further clarified.

Methods

Keywords such as angptl4, vascular permeability, angiogenesis, inflammation, and endothelial cells were used in search tool of PUBMED, and then the literatures associated with Angptl4 were founded and read.

Results

Data have established Angptl4 as the key modulator of both vascular permeability and angiogenesis; furthermore, it may also be related to the progression of metastatic tumors, cardiovascular events, and inflammatory diseases. This view focuses on the recent advances in our understanding of the role of Angptl4 in vascular permeability, angiogenesis, inflammatory signaling and the link between Angptl4 and multiple diseases such as cancer, cardiovascular diseases, diabetic retinopathy, and kidney diseases.

Conclusions

Taken together, Angptl4 modulates vascular permeability, angiogenesis, inflammatory signaling, and associated diseases. The use of Angptl4-modulating agents such as certain drugs, food constituents (such as fatty acids), nuclear factor (such as PPARα), and bacteria may treat associated diseases such as tumor metastasis, ischemic-reperfusion injury, inflammation, and chronic low-grade inflammation. However, the diverse physiological functions of Angptl4 in different tissues can lead to potentially deleterious side effects when used as a therapeutic target. In this regard, a better understanding of the underlying mechanisms for Angptl4 in different tissues is necessary.     

CD64 Expression Is Increased in Patients with Severe Acute Pancreatitis: Clinical Significance

Background/Aims

Upregulated CD64 expression on neutrophils is the most useful marker for acute bacterial infections and systemic inflammation. However, it is unknown whether CD64 is involved in the pathogenesis of acute pancreatitis (AP). This study was designed to determine whether CD64 is implicated in severe acute pancreatitis (SAP), and thus, is a suitable marker for SAP.

Methods

SAP was induced in rats with an intraperitoneal injection of L-arginine. CD64 expression in the rat pancreas was determined by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry. Additionally, the CD64 mRNA expression in peripheral blood leukocytes from 21 patients with mild acute pancreatitis (MAP) and 10 patients with SAP was investigated at the time of admission and during remission by qRT-PCR.

Results

CD64 mRNA and protein expression in the pancreas was significantly higher in rats with SAP, compared to the controls. The CD64 expression was higher in the patients with SAP than in the patients with MAP. During remission, CD64 mRNA decreased in both the MAP and SAP patients. The area under the curve of CD64 expression for the detection of SAP was superior to both the Ranson and the Acute Physiology and Chronic Health Evaluation II scores.

Conclusions

The CD64 level was significantly increased in correlation with the disease severity in SAP and may act as a useful marker for predicting the development of SAP.     

胸痛三联一站式动态容积 CT 检查的临床价值及意义

目的探讨同侧肺叶切除手术后由于各种原因可能对同侧余肺再次手术切除完成不同期全肺切除与一次性完成全肺切除的临床特点。方法分析本院40年来各种原因以同侧余肺切除完成不同时期全肺切除的患者36例（距第一次肺手术时间1～420个月）。结果全部患者均完成同侧余肺切除,手术后病理检查为余肺结核（31％,11／36）,余肺癌（31％,11／36）,余肺支气管扩张症（8％,3／36）,多发性肺囊肿（8％,3／36）,余肺感染、脓肿、坏死等（22％,8／36）。余肺切除后主要并发症有手术后胸腔感染（22％,8／36）,支气管胸膜瘘（14％,5／36）,严重心血管并发症并导致围手术期死亡（8％,3／36,分别为急性心肌梗死、肺动脉栓塞、恶性心律失常各1例）。结论同侧余肺切除完成不同期全肺切除的主要手术适应证是：①肺结核、肺癌复发;②支气管扩张症残留症状;③治疗肺叶切除术后余肺严重并发症。手术中出血较一般全肺切除多,术后主要并发症是胸腔内感染、支气管胸膜瘘及循环系统并发症。严格手术指征、了解第一次肺手术的全过程、提高手术技巧减少手术中出血、严谨的围手术期处理是余肺切除术取得成功的关键因素,对于同侧余肺切除完成不同期全肺切除如果手术适应证正确,围手术期处理得当,其临床结果是令人满意的。