人胚胎胃肠及胰腺D细胞发生的研究

用免疫细胞化学方法研究人胚胎各时期胃肠胰的Ｄ细胞发生及其形态与功能的关系。结果发现：Ｄ细胞最早出现于６周零５天胚的十二指肠，７周零３天胚的胰、胃、空肠，７周零６天胚的回肠，８周零４天胎的结肠及１０周零５天胎的阑尾；细胞密度在胚期低，胎期逐增，至胎晚期又依次在胰、胃窦、十二指肠、胃体、空肠、回肠、升结肠及阑尾中降低，且肠绒毛顶端可见衰老的Ｄ细胞。提示胚胎Ｄ细胞的发生与胃肠胰的发育有关。     

高血压病,冠心病患者血浆内皮素水平及其临床意义初探

本文检测了原发性高血压和冠心病患者血浆内皮素水平，结果发现原发性高血压Ⅰ、Ⅱ期组和冠心病心功代偿组血浆ＥＴ值与正常对照组无著差异；高血压Ⅲ期组及冠心病心衰组血浆ＥＴ值明显高于正常对照组，１２例冠心病心衰患者治疗后血浆ＥＴ水平明显降低。提示ＥＴ参与了原发性高血压严重并发症及冠心病心衰的发生和发展。冠心病患者血浆ＥＴ浓度与心功不全程度有关；高血压病患者血浆ＥＴ浓度与血压高低无关。     

Relative distribution of Schistosoma japonicum eggs in the intestine of man: a subject of inconsistency.

The relative distribution of Schistosoma japonicum eggs in the intestine of man is inconsistent in the literature. Some scientists believe that the adult S. japonicum worms reside mainly in the superior mesenteric vein and their eggs are deposited predominately in the small intestine, whereas others have shown that the adult worms have a predilection for inhabiting the branches of the inferior mesenteric vein and superior haemorrhoidal vein and their eggs are deposited in much higher density in the large intestine, especially in the rectum, sigmoid and descending colon, than in the small intestine. A review of the literature was made which includes the results from animal experiments as well as from human clinical and pathological studies. The author is in favour of the latter view that in man, S. japonicum eggs are deposited predominately in the large intestine and small intestine involvement is usually slight.     

Fulminant childhood hemophagocytic syndrome mimicking histiocytic medullary reticulosis. An atypical form of Epstein-Barr virus infection.

Ten cases of pediatric fulminant hemophagocytic syndrome, encountered between 1986 and 1989, are described. They occurred in the summer, and the patients presented with fever, jaundice, hepatosplenomegaly, pancytopenia, coagulopathy, and abnormal liver function. Bone marrow studies revealed infiltration by atypical T-lymphoid cells, rare B immunoblasts, and mature histiocytes with hemophagocytosis. Initially, histiocytic medullary reticulosis was suspected in six cases. The clinical course was characterized by rapid deterioration, with a mean period of 16 days from onset of fever to death. The main causes of death were coagulopathy with multiple organ failure and opportunistic infection. In seven of eight cases studied by serologic assay and Southern blot hybridization, acute or active Epstein-Barr virus (EBV) infection was documented. It is suggested that an atypical or fulminant form of primary EBV infection distinct from classic infectious mononucleosis was prevalent in previously healthy children in Taiwan. Younger age involvement and seasonal clustering were characteristic of the disorder described.     

糖尿病肾脏胶原非酶糖化与氨基胍阿斯匹林的治疗作用

本实验系统观察了ＳＴＺ所致糖尿病鼠在１、３、６个月后肾脏组织胶原发生非酶糖化的情况，及氨基胍、阿斯匹林对肾脏胶原非酶糖化的阻断作用。结果表明：各病程糖尿病动物肾组织的胶原含量和非酶糖化早期产物（５－ＨＭＦ）及胶原相联荧光值均明显高于正常对照。氨基胍能够减弱糖尿病动物肾组织胶原含量的增加和荧光产物的生成，但对５－ＨＭＦ含量无影响。阿斯匹林未显示出对胶原非酶糖化的影响。     

四肢带表浅静脉干的局部皮瓣在创伤修复中的应用

设计4种带表浅静脉干的局部皮瓣用于修复四肢创面14例,获得了满意的效果。该皮瓣所包含的一条浅静脉干,不仅有利于静脉回流,且其血流对皮瓣亦有营养作用。因此,该皮瓣容易成活,长宽比值可大于传统任意型皮瓣。并具有操作简便,不损伤主要动脉等优点。文中介绍了皮瓣的设计及手术方法,并对该皮瓣的血液循环特点、适应证及供区选择等进行了讨论。     

埃索美拉唑三联与奥美拉唑三联疗法治疗Hp阳性十二指肠溃疡对比研究

目的比较埃索美拉唑三联与奥美拉唑三联疗法治疗幽门螺杆菌（Hp）阳性十二指肠球部溃疡的临床疗效。方法将104例经内镜诊断并检测证实Hp阳性的十二指肠球部溃疡患者随机分为两组。埃索美拉唑组（52例）：埃索美托唑20mg＋阿莫西林1g＋克托霉素500mg，每日2次，共7d；奥美拉唑组（52例）：奥美拉唑20mg＋阿莫西林1g＋克拉霉素500mg，每日2次，共7d。疗程结束4周后复查胃镜并检测Hp，观察腹痛缓解率、溃疡愈合率、Hp根除率及用药后的不良反应等。结果埃索美拉唑组第1天和第2天腹痛缓解率分别为34．6％和59、6％，高于奥美托唑组的17.3％和38．5％（P〈0．05）。埃索美托唑组和奥美拉唑组溃疡愈合率分别为92.3％和88．5％，Hp根除率分别为88．5％和82．7％，差异无显著性（P〉0．05）。两组用药后不良反应少，有较好的安全性。结论埃索美拉唑三联疗法治疗Hp阳性的十二指肠溃疡安全有效．腹痛缓解速度优于奥美拉唑三联疗法。     

脊柱推拿时咔哒声响的测量技术分析与设计

目的 为研究脊住推拿时所发出咔哒声响，提供一套可采集、定位和分析的检测仪器。方法 在回顾咔哒声响测量技术现状的基础上，分析研究了实现声响测量的技术路线，设计了由时钟脉冲发生器、发送／接收接口、校准波发生器、复合传感器、计算机、测定分析软件以及输出部件等组成的声响测量系统。结果 经初步试验，在40cm的距离上测到了关节发出的咔哒声响，说明技术上基本可行。结论 本仪器可以作为脊柱推拿所致咔哒声响的采集、定位和分析系统使用。     

Diagnostic value of GDx polarimetry in a Taiwan Chinese population.

PURPOSE: To study the diagnostic ability of scanning laser polarimetry with variable corneal compensation (GDx VCC) for early glaucomatous (EG) eyes and glaucoma-suspect (GS) eyes in a Taiwan Chinese population. METHODS: This prospective cross-sectional study included 82 EG eyes (mean deviation, MD: -3.32 +/- 2.20 dB), 45 GS eyes (MD: -2.43 +/- 2.16 dB), and 62 normal eyes. Retinal nerve fiber layer thickness of each subject was measured using GDx VCC and Humphrey Field Analyzer visual field testing. Measured GDx VCC parameters were compared among groups. The area under the receiver operating characteristic (AROC) curve of each parameter was used to differentiate normal from EG eyes or GS eyes. The correlation between MD and each parameter was also evaluated. RESULTS: For both normal versus EG and normal versus GS, the largest AROC values were for nerve fiber indicator, superior average thickness, and inferior average thickness. There was no significant correlation between MD and GDx-VCC-measured parameters either in EG or GS eyes. CONCLUSIONS: GDx VCC shows only moderate ability to distinguish normal eyes from eyes with early glaucoma. However, its diagnostic role in eyes with suspicious discs and normal visual fields is uncertain at this moment in the Taiwan Chinese population. Further studies are needed to address this issue.     

嘉兴外来人员生活环境与肠道传染病相关知信行现况调查分析

目的了解城郊结合部外来人员聚集地生活环境现况和霍乱等肠道传染病健康知信行情况,进一步明确肠道传染病防治健康教育与健康促进工作的重点开展方向。方法采用随机抽样的方法,运用统一设计的调查问卷对嘉兴市5县2区城郊结合部等外来人员聚集地进行流行病学调查。结果93.06%的调查对象以租房为主,90.61%的生活用水来源于自来水,9.25%用井水;78.61%的人知道霍乱传播途径,21.53%的人知道霍乱主要临床症状,28.03%的人知道肠道传染病全部预防措施;77.31%的知识来源于电视,其他顺位依次为书刊、广播、家人或朋友处;希望获得宣传资料形式:传单占46.68%,墙报占31.21%。结论外来人员租房人数居多,有部分人使用井水;肠道传染病相关知识了解的较少。应采取多部门齐抓共管来改善外来人员聚集地的生活环境,因地制宜地对外来人员开展有针对性的预防肠道传染病健康教育。