齐拉西酮与奥氮平治疗早期精神分裂症的效果及安全性比较

目的 探讨齐拉西酮与奥氮平治疗早期精神分裂症的效果及安全性.方法 将本院收治100例早期精神分裂症患者随机分为对照组与实验组,各50例.对照组给予奥氮平治疗,试验组给予齐拉西酮治疗.比较两组临床疗效、自我管理能力等差异.结果 试验组总有效率为92.0％,高于对照组的88.0％,差异无统计学意义(P＞0.05).治疗后,试验组自我管理能力为(73.68±5.31)分,高于对照组的(60.66±4.37)分;试验组不良反应率为4.0％,低于对照组的20.0％;差异均具有统计学意义(均P＜0.05).结论 齐拉西酮较奥氮平治疗早期精神分裂症效果佳,值得临床选择.     

只守候你到这里

【他是才子,我便要做才女】室友说,叶儿,你哥来了。我来在阳台上果真看到了他,他穿着蓝色T恤,提了一包东西正往我的宿舍走。他很英俊,一米八的身高,     

针刺配合中药治疗中风后偏身汗出1例

脑血管病为中、老年人的常见病、多发病,也是导致人类死亡的三大主要疾病之一,临床多表现为肢体运动及感觉功能障碍,及不同程度的认知功能障碍等症状。而部分患者同时伴有不同程度的汗液排泄异常,或全身,或偏身,或局部的多汗、无汗。西医除治疗脑血管病外无相应的有效治疗方法     

葡萄球菌对常用抗菌药物的耐药性分析

目的调查了解本院临床葡萄球菌感染状况及对常用抗菌药物的耐药性特点，指导临床用药。方法采用常规方法鉴定菌种，用K—B法做抗菌药物体外药敏试验。结果分离出葡萄球菌238株，金黄色葡萄球菌、凝固酶阴性葡萄球菌各占36．1％及63．9％，耐甲氧西林金黄色葡萄球菌、耐甲氧西林凝固酶阴性葡萄球菌分离率分别为43．0％和60．5％；药敏试验显示出较高的耐药率，耐甲氧西林葡萄球菌（MRS）耐药率高于甲氧西林敏感葡萄球菌。MRS只对万古霉素有100％的抗菌活性。结论切实加强葡萄球菌耐药性监测，对指导临床合理用药和制定有效的治疗方案等具有十分重要的意义。     

IVF/ICSI-ET术后双胎妊娠的临床结局及预防对策

目的:分析体外受精 (in vitro fertilization,IVF)/卵细胞浆单精子注射-胚胎移植 (intracytoplasmic sperm injection-embryo transfer,ICSI-ET)术后双胎妊娠的临床生殖结局,探讨降低辅助生殖技术中多胎率的有效治疗措施?方法:回顾性分析IVF/ICSI-ET术后获得双胎妊娠的425例孕妇的妊娠并发症?分娩方式和围产期结局?结果:①行IVF/ICSI-ET 4 603个治疗周期,双胎率23.35%,流产率9.18%,妊娠并发症发生率13.41%,出生缺陷发生率1.60%;②活胎双胎组孕周[(29.66 ± 3.64周) vs. (30.69 ± 3.47周)]? 出生体重[(2.64 ± 0.45)kg vs. (3.12 ± 0.64)kg]低于活胎单胎组,剖宫产率(97.68% vs. 77.38%)?早产率(41.06% vs. 16.67%)?低体重儿发生率(42.05% vs. 19.05%)高于活胎单胎组,两组间比较差异有统计学意义;③多胎减胎组和自然减胎组比未减胎组获得良好的生殖结局,孕周[(38.00 ± 2.03)周?(37.89 ± 2.46)周 vs. (36.43 ± 1.77)周)]和出生体重[(3.05 ± 0.65)kg?(3.15 ± 0.63)kg vs. (2.64 ± 0.45)kg]?早产率(13.64%?15.71% vs 37.24%)等方面比较,差异均有统计学意义?结论:在辅助生殖技术中,双胎较单胎妊娠发生早产?低出生体重不良风险高,需重视其围生期保健和产前检查?临床早期预测并进行减胎等补救性手段是安全有效的干预措施?     

Effects of Electroacupuncture of Different Intensities on Energy Metabolism of Mitochondria of Brain Cells in Rats with Cerebral Ischemia-Reperfusion Injury

Objective: To observe the effects of electroacupuncture (EA) of different intensities on lactate dehydrogernase (LDH), succinate dehydrogenase (SDH) and ATPase in brain tissue of rats with cerebral ischemia-reperfusion injury (CI/R). Methods: Forty male SD rats were uniformly randomized into sham operation group (group A), CI/R group (group B), CI/R+5 mA EA (group C), CI/R+3 mA EA (group D) and CI/R+1 mA EA (group E) groups with eight rats in each group. Transient general brain ischemia was induced by four-vessel occlusion and reperfusion. The rats in group C, group D and group E were punctured and stimulated at Baihui (GV20), Mingmen (GV4) and Zusanli (ST36) with the same intermittent and rarefaction-dense wave (30 to 50 Hz) and different electric current intensities: 5 mA , 3 mA and 1 mA for 20 min after CI/R. Then the activities of Na+-K+-ATPase, SDH and LDH in mitochondria of brain tissue were measured by spectrophotometry. The ischemic cerebral cortex tissue was taken for observing the ultrastructure changes of impaired nerve cells. Results: Compared with group A, the activities of LDH, SDH and Na+-K+-ATPase were lowerer in the group B (P<0.05 or P<0.01). However, the activities of LDH, SDH and Na+-K+-ATPase were higher in the group D than those in the group B (P<0.05 or P<0.01). In group A, the anatomical structure of the cerebral cortex cells was basically normal; in group B, the neuronal cellular structures were severely damaged, the neuronal mitochondria got swelling, the mitochondrial cristae were broken, the medullated nerve fibers were not integrated. In group C, group D and group E, the ultrastructure of impaired neuron were improved. Group D was the best among three groups above. Conclusion: EA of 3 mA intensity could strengthen aerobic metabolism by elevating the activities of SDH and LDH, meanwhile maintaining the ionic equilibrium in the exterior and interior brain cell and relieving the cellular edema by reinforcing the activities of Na+-K+-ATPase.     

老年腹部术后患者睡眠障碍的影响因素及护理对策

目的：分析老年腹部术后患者睡眠障碍的影响因素,探讨有针对性的护理干预措施以改善患者的睡眠质量。方法对2012年10月至2013年10月我院收住的62例老年腹部术后睡眠障碍患者采用匹兹堡睡眠质量表进行调查,并用自制调查表对患者进行问卷调查,分析影响因素。结果影响62例老年腹部术后患者睡眠质量的因素为：老龄化因素、手术创伤及麻醉因素、疼痛因素、环境因素、心理因素。对该类患者采取包括围术期护理、舒适护理、心理护理、药物治疗等护理措施,效果令人满意。结论明确老年腹部术后患者睡眠障碍的原因所在,采取针对性的护理对策,能改善患者睡眠质量促进早日康复。     

左冠状动脉主干及其分支间的夹角与左冠状动脉斑块形成的相关性分析

目的利用冠状动脉(冠脉)CT血管成像(CT angiography,CTA)探讨左冠脉主干(left main coronary artery,LM)、左前降支(left anterior descending branch,LAD)、左回旋支(left circumflex branch,LCX)三者间的夹角与局部斑块形成和分布特征之间的相关性。方法对127例行冠脉CTA检查患者进行回顾性研究,分为正常组44例和左冠脉病变组83例,病变组进一步分为LM组(18例)、近段组(57例)、中远段组(8例)。在重建图像上测量LM、LAD、LCX三者之间的夹角,分析左冠脉夹角与局部斑块形成和分布特征之间的相关性。结果 127例患者LM与LAD间的夹角和LAD与LCX夹角(分支角)呈负相关(r=-0.356,P<0.05);LM与LCX间的夹角和分支角也呈负相关(r=-0.662,P<0.05)。近段组分支角(90.9°±20.0°)与正常组(72.7°±16.7°)比较差异有统计学意义(P<0.05)。近段组LM与LCX夹角(117.8°±16.0°)与正常组(129.5°±15.9°)比较有明显差异(P<0.05)。LAD近段斑块形成与分支角呈正相关,和LM与LCX夹角呈负相关。当分支角>70°时,左冠脉斑块形成概率将会增加。结论分支角、LM与LCX间夹角均与LAD近段斑块的形成和分布相关,利用多层螺旋CTA能够为左冠脉斑块形成、风险预测及介入治疗术前提供无创、准确、快捷的相关特征信息。