Studies on Toxicity of Nitroquine-Dapsone Compound and Therapeutic Effects of Folic or Folinic Acid on Toxicated Animals

The toxic effects of nitroquine-dapsone compound(NQD)in mice and dogs were studied.The therapeutic index of NQDin mice is 1911,the greatest among the 6 antimalarials tested.Thetoxic effects of NQD(50 mg/kg/day for 3 days per os)and nitro-quine in dogs were manifested by injuries on the adrenal cortexand intestinal epithelium.When folic acid(4 mg/kg/day for 4 days)or calcium leucovorinum(0.3 mg/kg/day for 4 days)were usedconcomitantly with NQD,the death rate and the incidence of dia-rrhea in the toxicated dogs were greatly reduced,the injury on theintestinal epithelium was much milder,and the goblet cells weremuch more numerous than those without treatment.The results suggestthat folic acid and calcium leucovorinum can protect the undifferen-tiated cells in the intestinal crypts from being injured by NQD.     

超声电丛刺治疗后急性脑梗死患者神经功能缺损及实验室相关指标的变化

目的:观察超声电丛刺头穴丛刺法治疗急性脑梗死的效果,以及治疗前后体感诱发电位指标及血液生化指标变化。方法:①选择2003-01/2005-06在沈阳脑科医院神经内科住院的急性脑梗死患者261例,男160例,女101例。均为首次患病,且对治疗方案知情同意。将上述患者随机分为2组:丛刺治疗组131例,对照组130例。②丛刺治疗组:采用超声电丛刺治疗仪于头部电丛刺顶区(运动区),以100～200Hz疏密波电针通过6～8h,1次/d,1个疗程30次。对照组:均予以常规脑血管病药物同等治疗。丛刺治疗组和对照组均干预30d。两组疗效判定标准:治疗后神经功能缺损评分减少91%～100%为基本恢复,减少46%～90%为显著进步,减少18%～45%为进步。③采用酶联免疫法测定血浆α-颗粒膜蛋白水平;应用放射免疫法测定血浆血栓素A2水平;采用酶联免疫吸附法双抗体夹心法测定血浆D-二聚体水平;采用免疫透射比浊方法测定脂蛋白(a)水平。应用神经电生理检测仪检测体感诱发电位。④计数和计量资料差异比较采用χ2检验和t检验。结果:急性脑梗死患者261例均进入结果分析。①丛刺治疗组131例中:基本恢复31例,显著进步80例,进步15例,总有效率为96%(126/131);对照组130例:基本恢复14例,显著进步68例,进步12例,总有效率为72%(96/130);丛刺治疗组总有效率明显高于对照组(P<0.01)。②丛刺治疗组治疗后血浆α-颗粒膜蛋白、血栓素A2、D-二聚体和脂蛋白(a)含量较治疗前明显降低(P<0.01)。③丛刺治疗组治疗后体感诱发电位的波潜伏期与传导时间较治疗前明显缩短(P<0.01)。结论:超声电丛刺治疗急性脑梗死效果显著,可显著改善急性脑梗死患者体感诱发电位指标及血液生化指标。     

危重患者经外周静脉置入中心静脉导管的临床研究——前瞻性随机对照研究

目的 比较经外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)与经锁骨下静脉中心静脉置管在危重患者中的临床应用.方法 通过前瞻性随机对照研究方法,将80例ICU危重患者分为PICC组(40例)和锁骨下静脉组(40例),观察两组穿刺成功率、穿刺时间、穿刺不良反应发生率等.结果 PICC组较锁骨下静脉组一次穿刺成功率高(92.5%vs 75.0%,χ2=4.501,P=0.034),穿刺时间短[(15.7±5.3)min vs(23.9±6.3)min,t=-6.263,P=0.000],总不良反应发生率低(10.0%vs 27.5%,χ2=4.021,P=0.045).结论 PICC穿刺简便易行,危险性小,在危重患者中PICC置管优于锁骨下静脉置管.     

Performance and comparison of the Cockcroft-Gault and simplified Modification of Diet in Renal Disease formulae in estimating glomerular filtration rate in a Chinese Type 2 diabetic population.

AIMS: Our aim was to assess performances of the Cockcroft-Gault and simplified Modification of Diet in Renal Disease (MDRD) formulae in estimating glomerular filtration rate (GFR) in Chinese diabetic populations and their association with vascular risks. METHODS: A total of 1009 patients with Type 2 diabetes were categorized into low estimated GFR groups (GFR < 60 ml/min/1.73 m(2)) and control groups by the two equations. The performances of these formulae were assessed at different stages of kidney function. Carotid artery intima-media thickness (IMT) and the prevalence of diabetic retinopathy or albuminuria were compared among the groups. The ability of these formulae to identify established vascular risk markers using sensitivity, specificity, positive and negative predictive values were also compared. RESULTS: The prevalence of low estimated GFR was 32.7% with the Cockcroft-Gault formula and 5.2% with the MDRD formula, respectively. In low estimated GFR subjects by the MDRD formula, IMT was significantly thicker than those by the Cockcroft-Gault formula (1.2 mm vs. 1.0 mm; P < 0.05), with a higher prevalence of albuminuria (78.4 vs. 52.8%, P < 0.05) and diabetic retinopathy (46.5 vs. 30.5%; P < 0.05). The Cockcroft-Gault formula gave a specificity of 71.7% and a sensitivity of 37.0%, and the MDRD formula gave a specificity of 96.6% and a sensitivity of 7.9% in estimating low GFR relevant for established vascular risks. CONCLUSIONS: These formulae performed differently in Chinese diabetic populations. The simplified MDRD formula is minimally superior to the Cockcroft-Gault formula for its high specificity and positive predictive values in estimating low GFR relevant for vascular risks.     

从六经辨治腰椎间盘突出症

腰椎间盘突出症是临床常见病、多发病。随着现代影像诊断技术的发展,该病的诊断越来越明确,治疗方法多有牵引、针灸、理疗、穴注等,具体到针灸治疗本病症,则多从足太阳、足少阳、足少阴论治,笔者从六经辨治本症,取得较好疗效,现分经论述如下。1太阳证(1)表现:恶寒,全身酸胀不适;或恶风汗出,腰背有僵硬感;或腰臀部及下肢后外侧牵强不适;更甚者脊柱和腰部像折断一样疼痛,下肢不能运动自如。查舌淡、苔薄白或薄黄,脉浮紧或浮缓或弦。(2)处方:合谷、列缺、外关、后溪、风门、膀胱俞、委中、昆仑、京骨、大钟、金门等。以泻法为主。(3)方义:太阳…     

自拟带状疱疹方治疗带状疱疹26例

带状疱疹由于其灼痛钻心、皮肤红斑、群集小疱,在中医文献中列入“丹门”;又因其好发于胸肋、腰部,故又名“缠腰火丹”.其病因病机多为毒邪、肝火、湿热、气血瘀阻.毒火留于血分发为红斑;湿热困于肝脾遂起水疱;气血阻于经络则见疼痛,临床上多以清泻肝火、渗利湿热、活血止痛为治.笔者使用自拟带状疱疹方治疗26例带状疱疹,经临床观察,疗效满意,现介绍如下.     

中医医院管理循证理念的应用

随着"三医改革"的不断深入,医疗市场的竞争日趋激烈,人们对医院管理在生存和发展中的重要作用也日益关注.由于中医院面临着管理理念、资源优化、人才构筑和公平竞争的诸多问题,以往的经验管理已不能适应时代性、国际化的要求.面对瞬息万变的生存环境,需要各级中医医院能够主动参与竞争,充分发挥中医药特色,强化自身优势,对市场的变化迅速作出反应,这对中医医院管理工作提出了更高的要求.     

类风湿关节炎伴发抑郁症动物模型的建立

目的：建立类风湿关节炎伴发抑郁症动物模型。方法：以复合造模思路，在采用胶原诱导复制大鼠类风湿关节炎模型基础上，结合孤养法和慢性不可预知的温和应激方法，造成类风湿关节炎伴发抑郁症动物模型。结果：造模后给予行为学测试和下丘脑5-HT、5-HIAA含量测定，模型组大鼠踝关节肿大畸形，关节炎指数增高，蔗糖水饮用量、旷野试验中水平及垂直得分、下丘脑5-HT、5-HIAA含量都明显小于正常组，有非常显著性差异（P〈0．01）。结论：类风湿关节炎伴发抑郁症动物模型关节肿大畸形，关节炎指数增高，呈抑郁状态，兴趣丧失，快感缺乏，运动迟滞等，能充分模拟类风湿关节炎伴发抑郁患者的核心症状，实验重复性较好，是研究类风湿关节炎伴发抑郁的理想模型。     

中重度安定中毒的中医证候特点研究

目的：总结中重度安定类药物中毒的中医证候学特点。方法：对40例中重度安定中毒患者进行中医症状证候学观察并进行统计学分析。结果：在中重度安定类药物中毒患者中以神志迷蒙、静卧不烦为其主要症状。其中气息微弱、目合口开、面色苍白、大汗淋漓、肤冷肢凉等症状所占比例较大，中医辨证多为阳脱，气脱。口水痰多、牙关紧闭、两手握固、肢体强痉等症状出现频率亦相对较高，中医辨证多为阴闭证。结论：中重度安定中毒患者常常出现正气严重受损，气阴两伤，中医辨证多属阴闭证，脱证（阳脱、气脱较阴脱多见）。     

Early uptake of 99mTc-C2A in the acute phase of myocardial infarction as a prognostic indicator for follow-up cardiac dysfunction

OBJECTIVE: The C2A domain of Synaptotagmin I is a molecular probe for the specific imaging of cell death. Here we test the hypothesis that the uptake of 99mTc-C2A in the acute phase of an infarction is associated with cardiac dysfunction in follow-ups. METHODS: The left coronary artery was occluded in Sprague-Dawley rats for 0, 10, 20, and 30 min. 99mTc-C2A was injected intravenously at 2 h of reperfusion. Anterior planar images were acquired with one million counts on a gamma camera 3 h after injection. 99mTc-C2A uptake was calculated as the total counts in the left ventricle region minus blood pool signal. The in-vivo signal detected was correlated with wall motion score index at 1 and 3 weeks follow-ups measured by echocardiography. RESULTS: 99mTc-C2A uptake was higher with increased ischemic time (2244+/-852, 4054+/-1223, and 6178+/-1451 for 10, 20, and 30 min ischemia, analysis of variance P<0.001). A significant correlation was found between 99mTc-C2A uptake and wall motion score index at 1 week (R=0.800, P=0.0006) and 3 weeks (R=0.810, P=0.0008). CONCLUSION: In this ischemia/reperfusion model, 99mTc-C2A uptake in the acute phase was associated with functional abnormality at 1 and 3 weeks. This demonstrates the potential diagnostic and prognostic value of 99mTc-C2A as a novel imaging agent.