重度阻塞性睡眠呼吸暂停综合征合并高血压患者血浆尾加压素Ⅱ的研究

目的探讨尾加压素(UⅡ)在重度阻塞性睡眠呼吸暂停综合征合并高血压病患者病理生理过程中的作用及意义。方法择正常人30例(对照组)和重度阻塞性睡眠呼吸暂停综合征合并高血压病患者30例(试验组),采用放射免疫法测定血浆中UⅡ的水平。结果试验组患者血浆UⅡ的水平为(9.0±1.0)pg/ml,对照组为(7.1±1.0)pg/ml,两组间差别有显著性意义(P<0.005);试验组与对照组氧饱和度分别为(63.4±2.2)%和(93.3±5.6)%,两组间差别有显著性意义(P<0.001)。结论UⅡ的增高可能是重度阻塞性睡眠呼吸暂停综合征合并高血压病患者疾病发生、发展的重要因素。     

绿脓杆菌内毒素蛋白疫苗治疗绿脓杆菌感染207例

本文报告绿脓杆菌内毒素蛋白疫苗对207例绿脓杆菌感染的临床疗效。121例烧伤后绿脓杆菌感染患者中31例治疗后创面细菌培养29例阴转(94％),治疗组阴转率明显高于对照组(P<0.05),创面愈合时间明显缩短。86例非烧伤绿脓杆菌感染患者治疗后总有效率为79％,伤口术后感染疗效高达92％。     

Intrinsic PEEP on static pressure-volume curves

The static pressure volume (PV) curve of the total respiratory system is a well established method to assess pulmonary mechanics during respiratory failure. We have tested the impact of auto-PEEP on the PV curve determination in 16 COPD patients. An isovolumic pressure increment (IPI) was found at the beginning of the curve and a close correlation between IPI and auto-PEEP level (r=0.962)p<0.001) was observed. The regression equation was not significantly different from the identity line. We conclude that the appearance of IPI in PV curves is largely determined by auto-PEEP and it is a good estimate of the existing auto PEEP level.     

Long-term neuropsychological impact of brief occupational exposure to organic solvents.

This case series describes the cognitive functioning of 10 individuals who were briefly exposed to a mixture of organic solvents as a result of an industrial accident. Data were obtained 10 years after the exposure on measures of intellect, memory, attention, and executive functioning, using standardised neuropsychological measures including WAIS III, WMS III, Hayling and Brixton Tests, The Trail Making Test, Controlled Oral Word Association, Rey-Osterrieth Complex Figure Test, and The Speed and Capacity of Language-Processing Test. The group performed in the average range across the majority of measures but deficits (z > 1.0 S.D.) were observed on tests that measure speed of information processing, memory, attention, and verbal fluency. Discrepancy scores between the NART and the WAIS suggest subtle but statistically significant decline in performance IQ following solvent exposure.     

精神病患者院前自杀行为的调查及护理对策

目的了解精神病患者院前自杀行为的特点，提出针对性的预防措施。方法采用问卷调查法对51例院前自杀的精神病患者及家属进行有关自杀的地点、方法及原因的调查。结果精神病患者在院前自杀有一定的特征性，自杀时间在下午最多，自杀方法以过量服药为多，疾病种类不同采用的方法和自杀的原因也不同，41例有自杀先兆。结论精神病患者需要家庭、社会的关心理解和支持，重视家庭护理和社会支持，以预防和减少精神病患者自杀的发生。     

连续非卧床性腹膜透析治疗糖尿病肾病的护理

目的：了解经连续非卧床性腹膜透析（CAPD）治疗糖尿病肾病（DN）患的临床特点，以指导护理。方法：收集经CAPD治疗的91例DN患与非透析治疗的72例DN患资料进行分析，比较其低血糖、低血钾的发生率、发生诱因及症状。结果：CAPD治疗组低血糖、低血钾的发生率分别为39％,48％，较非透析治疗组18％，26％高（ P＜0．05）。饮食减少是CAPD治疗组发生低血糖、低血钾的主要原因，而非透析治疗组低血糖、低血钾则主要由胰岛素使用不当及腹泻引起。提示，以CAPD治疗的糖尿病肾病患低血糖、低血钾发生率、发生诱因及症状均不同于非透析 治疗组，护理时应区别对待。     

基于多中心真实世界研究再评价舒泌通胶囊治疗湿热瘀滞证慢性前列腺炎的临床疗效

目的:再评价舒泌通胶囊治疗湿热瘀滞证型慢性前列腺炎(CP)的临床疗效。方法:纳入1872例CP患者,在其常规治疗的基础上服用舒泌通胶囊治疗,每次4粒,每日3次,4周为1个疗程,观察治疗2个疗程。观察治疗前后NIH-CPSI评分(包括疼痛症状评分、排尿症状评分及生活质量评分),治疗前后症状分级量化积分情况,并观察不良反应。结果:治疗后总有效率为95.5%,治疗后NIH-CPSI总分及疼痛症状、排尿症状、生活质量评分较治疗前均显著减少(P<0.05);治疗后中医证候总有效率达98.9%,单项证候总有效率在79.5%~97.6%之间。结论:舒泌通胶囊可显著改善CP患者的临床症状,值得临床进一步研究及应用。     

两种不同固位结构附着体义齿修复游离端缺失基牙及缺牙区牙槽嵴应力分布的比较

目的探讨不同固位结构的附着体义齿应力分布特点,为临床应用附着体义齿种类的选择提供依据。方法应用三维有限元的方法分别测定并比较应用键槽缓冲式附着体和柱状附着体修复下颌单侧游离端缺失基牙及牙槽嵴应力分布情况。结果键槽缓冲式附着体义齿对基牙产生应力值小于柱状附着体义齿,对缺牙区牙槽嵴应力大于柱状附着体义齿。结论键槽缓冲式附着体义齿较适合于基牙条件差的义齿修复,柱状附着体义齿较适合于缺牙区牙槽嵴条件差的义齿修复。