收费全文 | 35882篇 |
免费 | 3281篇 |
国内免费 | 2585篇 |
耳鼻咽喉 | 404篇 |
儿科学 | 421篇 |
妇产科学 | 414篇 |
基础医学 | 4195篇 |
口腔科学 | 634篇 |
临床医学 | 4950篇 |
内科学 | 4899篇 |
皮肤病学 | 424篇 |
神经病学 | 2020篇 |
特种医学 | 1350篇 |
外国民族医学 | 25篇 |
外科学 | 3255篇 |
综合类 | 6907篇 |
现状与发展 | 11篇 |
预防医学 | 2167篇 |
眼科学 | 1149篇 |
药学 | 3683篇 |
28篇 | |
中国医学 | 2010篇 |
肿瘤学 | 2802篇 |
2024年 | 83篇 |
2023年 | 623篇 |
2022年 | 1023篇 |
2021年 | 1911篇 |
2020年 | 1494篇 |
2019年 | 1266篇 |
2018年 | 1327篇 |
2017年 | 1273篇 |
2016年 | 1056篇 |
2015年 | 1687篇 |
2014年 | 2085篇 |
2013年 | 1802篇 |
2012年 | 2802篇 |
2011年 | 2904篇 |
2010年 | 1748篇 |
2009年 | 1413篇 |
2008年 | 1656篇 |
2007年 | 1779篇 |
2006年 | 1787篇 |
2005年 | 1784篇 |
2004年 | 1137篇 |
2003年 | 1088篇 |
2002年 | 950篇 |
2001年 | 835篇 |
2000年 | 852篇 |
1999年 | 998篇 |
1998年 | 621篇 |
1997年 | 678篇 |
1996年 | 517篇 |
1995年 | 433篇 |
1994年 | 372篇 |
1993年 | 225篇 |
1992年 | 285篇 |
1991年 | 251篇 |
1990年 | 205篇 |
1989年 | 185篇 |
1988年 | 172篇 |
1987年 | 134篇 |
1986年 | 102篇 |
1985年 | 77篇 |
1984年 | 36篇 |
1983年 | 20篇 |
1982年 | 27篇 |
1981年 | 15篇 |
1980年 | 8篇 |
1979年 | 9篇 |
1965年 | 2篇 |
1940年 | 3篇 |
1935年 | 2篇 |
1934年 | 1篇 |
Methods and Results: This case-control association study contained 1673 samples, including 869 ophthalmic patients and 804 controls. Twelve tag SNPs have been selected from the MYP10 and MYP15 loci and genotyped by SNaPshot method. Among 12 SNPs, rs4840437 and rs6989782 in TNKS gene were found significant association with HM. Carriers of rs4840437G allele and rs4840437GG genotype created a low risk of high myopia (P = .036, OR = 0.81, 95%CI = 0.71–0.93; P = .016, OR = 0.73, 95%CI = 0.56–0.96; respectively). Carriers of rs6989782T allele and rs6989782TT+CT genotype also had a decreased risk of high myopia (P = .048, OR = 0.82, 95%CI = 0.71–0.94; P = .006, OR = 0.74, 95%CI = 0.59–0.92; respectively). Other 10 SNPs displaced nonsignificant association with HM. Additionally, the risk haplotype AC and the protective haplotype GT, generated by two SNPs in TNKS, were considerably more likely to be association with HM (for AC, P = .002 and OR = 1.26; for GT, P = .027 and OR = 0.84).
Conclusions: Our results demonstrated that some heritable variants in the TNKS gene are associated with HM in the Han population. The possible functions of TNKS in the development and pathogenesis of hereditary high myopia still require further researches to identify. 相似文献
In the area of large-scale graph data representation and semi-supervised learning, deep graph-based convolutional neural networks have been widely applied. However, typical graph convolutional network (GCN) aggregates information of neighbor nodes based on binary neighborhood similarity (adjacency matrix). It treats all neighbor nodes of one node equally, which does not suppress the influence of dissimilar neighbor nodes. In this paper, we investigate GCN based on similarity matrix instead of adjacency matrix of graph nodes. Gaussian heat kernel similarity in Euclidean space is first adopted, which is named EGCN. Then biologically inspired manifold similarity is trained in reproducing kernel Hilbert space (RKHS), based on which a manifold GCN (named MGCN) is proposed for graph data representation and semi-supervised learning with four different kernel types. The proposed method is evaluated with extensive experiments on four benchmark document citation network datasets. The objective function of manifold similarity learning converges very quickly on different datasets using various kernel functions. Compared with state-of-the-art methods, our method is very competitive in terms of graph node recognition accuracy. In particular, the recognition rates of MGCN (Gaussian kernel) and MGCN (Polynomial Kernel) outperform that of typical GCN about 3.8% on Cora dataset, 3.5% on Citeseer dataset, 1.3% on Pubmed dataset and 4% on Cora_ML dataset, respectively. Although the proposed MGCN is relatively simple and easy to implement, it can discover local manifold structure by manifold similarity learning and suppress the influence of dissimilar neighbor nodes, which shows the effectiveness of the proposed MGCN.
相似文献